Genetic Polymorphism and mRNA Expression Studies Reveal IL6R and LEPR Gene Associations with Reproductive Traits in Chinese Holsteins Article Swipe
Hailiang Zhang
,
Abdul Sammad
,
Rui Shi
,
Yixin Dong
,
Shanjiang Zhao
,
Lin Liu
,
Gang Guo
,
Qing Xu
,
Aoxing Liu
,
Yachun Wang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/agriculture13020321
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/agriculture13020321
Genetic selection of milk yield traits alters the energy distribution of high producing cows, resulting in gene-induced negative energy balance, and consequently, poor body condition scores and reduced reproductive performances. Here, we investigated two metabolic-syndrome pathway genes, IL6R (Interleukin 6 receptor) and LEPR (Leptin receptor), for their polymorphism effects on reproductive performance in dairy cows, by applying polymorphism association analyses in 1588 Chinese Holstein cows (at population level) and gene expression analyses in granulosa cells isolated from eight cows (at cell level). Among the six single nucleotide polymorphisms we examined (two SNPs for IL6R and four SNPs for LEPR), five were significantly associated with at least one reproductive trait, including female fertility traits covering both the ability to recycle after calving and the ability to conceive and keep pregnancy when inseminated properly, as well as calving traits. Notably, the identified variant SNP g.80143337A/C in LEPR is a missense variant. The role of IL6R and LEPR in cattle reproduction were further confirmed by observed differences in relative gene expression levels amongst granulosa cells with different developmental stages. Collectively, the functional validation of IL6R and LEPR performed in this study improved our understanding of cattle reproduction while providing important molecular markers for genetic selection of reproductive traits in high-yielding dairy cattle.
Related Topics
Concepts
Biology
Single-nucleotide polymorphism
Genetics
Leptin receptor
Candidate gene
SNP
Polymorphism (computer science)
Gene
Population
Quantitative trait locus
Endocrinology
Leptin
Genotype
Obesity
Medicine
Environmental health
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/agriculture13020321
- https://www.mdpi.com/2077-0472/13/2/321/pdf?version=1676452578
- OA Status
- gold
- Cited By
- 3
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4318480086
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4318480086Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/agriculture13020321Digital Object Identifier
- Title
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Genetic Polymorphism and mRNA Expression Studies Reveal IL6R and LEPR Gene Associations with Reproductive Traits in Chinese HolsteinsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-01-28Full publication date if available
- Authors
-
Hailiang Zhang, Abdul Sammad, Rui Shi, Yixin Dong, Shanjiang Zhao, Lin Liu, Gang Guo, Qing Xu, Aoxing Liu, Yachun WangList of authors in order
- Landing page
-
https://doi.org/10.3390/agriculture13020321Publisher landing page
- PDF URL
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https://www.mdpi.com/2077-0472/13/2/321/pdf?version=1676452578Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2077-0472/13/2/321/pdf?version=1676452578Direct OA link when available
- Concepts
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Biology, Single-nucleotide polymorphism, Genetics, Leptin receptor, Candidate gene, SNP, Polymorphism (computer science), Gene, Population, Quantitative trait locus, Endocrinology, Leptin, Genotype, Obesity, Medicine, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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58Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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