Genetic study of psoriasis highlights its close link with socio-economic status and affective symptoms Article Swipe
Anni Heikkilä
,
Eeva Sliz
,
Laura Huilaja
,
FinnGen
,
Kadri Reis
,
Priit Palta
,
Abdelrahman G. Elnahas
,
Anu Reigo
,
Tõnu Esko
,
Triin Laisk
,
Maris Teder‐Laving
,
Kaisa Tasanen
,
Johannes Kettunen
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.03.24.23287463
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.03.24.23287463
Psoriasis is an inflammatory skin disease with an estimated heritability of around 70 %. Previous genome-wide association studies (GWASs) have detected several risk loci for psoriasis. To further improve the understanding of the genetic risk factors impacting the disease, we conducted a discovery GWAS in FinnGen and a subsequent replication and meta-analysis with data from the Estonian Biobank and the UK biobank; the study sample included 925 649 individuals (22 659 cases and 902 990 controls), the largest sample for psoriasis yet. In addition, we conducted downstream analyses to find out more about psoriasis’ cross-trait genetic correlations and causal relationships. We report 8 novel risk loci, most of which harbor genes related to nuclear factor kappa-light-chain-enhancer of activated B-cells-signaling pathway and overall immunity. Genetic correlations highlight the relationship between psoriasis and smoking, higher body weight, and lower education level. Additionally, we report novel causal relationships between psoriasis and mood symptoms, as well as two-directioned causal relationship between psoriasis and lower education level. Our results provide new knowledge on psoriasis risk factors, which may be useful in the development of future treatment strategies.
Related Topics
Concepts
Psoriasis
Biobank
Genome-wide association study
Missing heritability problem
Disease
Heritability
Genetic association
Medicine
Genetics
Biology
Genotype
Immunology
Internal medicine
Gene
Genetic variants
Single-nucleotide polymorphism
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.03.24.23287463
- https://www.medrxiv.org/content/medrxiv/early/2023/03/28/2023.03.24.23287463.full.pdf
- OA Status
- green
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4361019848
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4361019848Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2023.03.24.23287463Digital Object Identifier
- Title
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Genetic study of psoriasis highlights its close link with socio-economic status and affective symptomsWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-03-28Full publication date if available
- Authors
-
Anni Heikkilä, Eeva Sliz, Laura Huilaja, FinnGen, Kadri Reis, Priit Palta, Abdelrahman G. Elnahas, Anu Reigo, Tõnu Esko, Triin Laisk, Maris Teder‐Laving, Kaisa Tasanen, Johannes KettunenList of authors in order
- Landing page
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https://doi.org/10.1101/2023.03.24.23287463Publisher landing page
- PDF URL
-
https://www.medrxiv.org/content/medrxiv/early/2023/03/28/2023.03.24.23287463.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.medrxiv.org/content/medrxiv/early/2023/03/28/2023.03.24.23287463.full.pdfDirect OA link when available
- Concepts
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Psoriasis, Biobank, Genome-wide association study, Missing heritability problem, Disease, Heritability, Genetic association, Medicine, Genetics, Biology, Genotype, Immunology, Internal medicine, Gene, Genetic variants, Single-nucleotide polymorphismTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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62Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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