Genetic variants and cognitive functions in patients with brain tumors Article Swipe
Denise D. Correa
,
Jaya M. Satagopan
,
Axel Martin
,
Erica Braun
,
Maria Kryza‐Lacombe
,
Kenneth Cheung
,
Ajay Sharma
,
Sofia Dimitriadoy
,
Kelli O’Connell
,
Siok Leong
,
Sasan Karimi
,
John K. Lyo
,
Lisa M. DeAngelis
,
Irene Orlow
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/noz094
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/noz094
Background Patients with brain tumors treated with radiotherapy (RT) and chemotherapy (CT) often experience cognitive dysfunction. We reported that single nucleotide polymorphisms (SNPs) in the APOE, COMT, and BDNF genes may influence cognition in brain tumor patients. In this study, we assessed whether genes associated with late-onset Alzheimer’s disease (LOAD), inflammation, cholesterol transport, dopamine and myelin regulation, and DNA repair may influence cognitive outcome in this population. Methods One hundred and fifty brain tumor patients treated with RT ± CT or CT alone completed a neurocognitive assessment and provided a blood sample for genotyping. We genotyped genes/SNPs in these pathways: (i) LOAD risk/inflammation/cholesterol transport, (ii) dopamine regulation, (iii) myelin regulation, (iv) DNA repair, (v) blood–brain barrier disruption, (vi) cell cycle regulation, and (vii) response to oxidative stress. White matter (WM) abnormalities were rated on brain MRIs. Results Multivariable linear regression analysis with Bayesian shrinkage estimation of SNP effects, adjusting for relevant demographic, disease, and treatment variables, indicated strong associations (posterior association summary [PAS] ≥ 0.95) among tests of attention, executive functions, and memory and 33 SNPs in genes involved in: LOAD/inflammation/cholesterol transport (eg, PDE7A, IL-6), dopamine regulation (eg, DRD1, COMT), myelin repair (eg, TCF4), DNA repair (eg, RAD51), cell cycle regulation (eg, SESN1), and response to oxidative stress (eg, GSTP1). The SNPs were not significantly associated with WM abnormalities. Conclusion This novel study suggests that polymorphisms in genes involved in aging and inflammation, dopamine, myelin and cell cycle regulation, and DNA repair and response to oxidative stress may be associated with cognitive outcome in patients with brain tumors.
Related Topics
Concepts
Single-nucleotide polymorphism
Cognitive decline
Internal medicine
Medicine
Population
Bioinformatics
Oncology
Endocrinology
Dementia
Biology
Disease
Genetics
Genotype
Gene
Environmental health
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/neuonc/noz094
- https://academic.oup.com/neuro-oncology/article-pdf/21/10/1297/30122439/noz094.pdf
- OA Status
- bronze
- Cited By
- 30
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2945968972
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2945968972Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/neuonc/noz094Digital Object Identifier
- Title
-
Genetic variants and cognitive functions in patients with brain tumorsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-05-22Full publication date if available
- Authors
-
Denise D. Correa, Jaya M. Satagopan, Axel Martin, Erica Braun, Maria Kryza‐Lacombe, Kenneth Cheung, Ajay Sharma, Sofia Dimitriadoy, Kelli O’Connell, Siok Leong, Sasan Karimi, John K. Lyo, Lisa M. DeAngelis, Irene OrlowList of authors in order
- Landing page
-
https://doi.org/10.1093/neuonc/noz094Publisher landing page
- PDF URL
-
https://academic.oup.com/neuro-oncology/article-pdf/21/10/1297/30122439/noz094.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://academic.oup.com/neuro-oncology/article-pdf/21/10/1297/30122439/noz094.pdfDirect OA link when available
- Concepts
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Single-nucleotide polymorphism, Cognitive decline, Internal medicine, Medicine, Population, Bioinformatics, Oncology, Endocrinology, Dementia, Biology, Disease, Genetics, Genotype, Gene, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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30Total citation count in OpenAlex
- Citations by year (recent)
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2025: 7, 2023: 4, 2022: 7, 2021: 6, 2020: 6Per-year citation counts (last 5 years)
- References (count)
-
52Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| primary_location.source.host_organization_lineage_names | Oxford University Press, University of Oxford |
| primary_location.license | |
| primary_location.pdf_url | https://academic.oup.com/neuro-oncology/article-pdf/21/10/1297/30122439/noz094.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
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| primary_location.is_published | True |
| primary_location.raw_source_name | Neuro-Oncology |
| primary_location.landing_page_url | https://doi.org/10.1093/neuonc/noz094 |
| publication_date | 2019-05-22 |
| publication_year | 2019 |
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