Genetically engineered insects with sex-selection and genetic incompatibility enable population suppression Article Swipe
Ambuj Upadhyay
,
Nathan R. Feltman
,
Adam Sychla
,
Siba R. Das
,
Maciej Maselko
,
Michael J. Smanski
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.06.11.448100
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.06.11.448100
Engineered Genetic Incompatibility (EGI) is a method to create species-like barriers to sexual reproduction. It has applications in pest control that mimic Sterile Insect Technique when only EGI males are released. This can be facilitated by introducing conditional female-lethality to EGI strains to generate a sex-sorting incompatible male system (SSIMS). Here we demonstrate a proof of concept by combining tetracycline-controlled female lethality constructs with a pyramus -targeting EGI line in the model insect Drosophila melanogaster . We show that both functions (incompatibility and sex-sorting) are robustly maintained in the SSIMS line and that this approach is effective for population suppression in cage experiments. Further we show that SSIMS males remain competitive with wild-type males for reproduction with wild-type females, including at the level of sperm competition.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.06.11.448100
- https://www.biorxiv.org/content/biorxiv/early/2021/06/11/2021.06.11.448100.full.pdf
- OA Status
- green
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3170738319
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3170738319Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2021.06.11.448100Digital Object Identifier
- Title
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Genetically engineered insects with sex-selection and genetic incompatibility enable population suppressionWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-06-11Full publication date if available
- Authors
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Ambuj Upadhyay, Nathan R. Feltman, Adam Sychla, Siba R. Das, Maciej Maselko, Michael J. SmanskiList of authors in order
- Landing page
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https://doi.org/10.1101/2021.06.11.448100Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2021/06/11/2021.06.11.448100.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2021/06/11/2021.06.11.448100.full.pdfDirect OA link when available
- Concepts
-
Biology, Lethality, Sterile insect technique, Drosophila melanogaster, Population, Sorting, Selection (genetic algorithm), Reproduction, Mating, Genetics, Evolutionary biology, PEST analysis, Computer science, Gene, Artificial intelligence, Demography, Programming language, Botany, SociologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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38Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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