Genomic Epidemiology of Major Extraintestinal Pathogenic Escherichia coli Lineages Causing Urinary Tract Infections in Young Women Across Canada Article Swipe
Chad Fibke
,
Matthew A. Croxen
,
Hyun Min Geum
,
Magdalena Glass
,
Eugenia Wong
,
Brent P. Avery
,
Danielle Daignault
,
Michael R. Mulvey
,
Richard J. Reid‐Smith
,
E. Jane Parmley
,
Andrea Portt
,
Patrick Boerlin
,
Amee R. Manges
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1093/ofid/ofz431
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1093/ofid/ofz431
Background A few extraintestinal pathogenic Escherichia coli (ExPEC) multilocus sequence types (STs) cause the majority of community-acquired urinary tract infections (UTIs). We examine the genomic epidemiology of major ExPEC lineages, specifically factors associated with intestinal acquisition. Methods A total of 385 women with UTI caused by E. coli across Canada were asked about their diet, travel, and other exposures. Genome sequencing was used to determine both ST and genomic similarity. Logistic regression was used to identify factors associated with the acquisition of and infection with major ExPEC STs relative to minor ExPEC STs. Results ST131, ST69, ST73, ST127, and ST95 were responsible for 54% of all UTIs. Seven UTI clusters were identified, but genomes from the ST95, ST127, and ST420 clusters exhibited as few as 3 single nucleotide variations across the entire genome, suggesting recent acquisition. Furthermore, we identified a cluster of UTIs caused by 6 genetically-related ST1193 isolates carrying mutations in gyrA and parC. The acquisition of and infection with ST69, ST95, ST127, and ST131 were all associated with increased travel. The consumption of high-risk foods such as raw meat or vegetables, undercooked eggs, and seafood was associated with acquisition of and infection with ST69, ST127, and ST131, respectively. Conclusions Reservoirs may aid in the dissemination of pandemic ExPEC lineages in the community. Identifying ExPEC reservoirs may help prevent future emergence and dissemination of high-risk lineages within the community setting.
Related Topics
Concepts
Multilocus sequence typing
Biology
Epidemiology
Escherichia coli
Genome
Genetics
Medicine
Gene
Genotype
Internal medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ofid/ofz431
- https://academic.oup.com/ofid/article-pdf/6/11/ofz431/30341358/ofz431.pdf
- OA Status
- gold
- Cited By
- 38
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2966277491
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2966277491Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/ofid/ofz431Digital Object Identifier
- Title
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Genomic Epidemiology of Major Extraintestinal Pathogenic Escherichia coli Lineages Causing Urinary Tract Infections in Young Women Across CanadaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-10-08Full publication date if available
- Authors
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Chad Fibke, Matthew A. Croxen, Hyun Min Geum, Magdalena Glass, Eugenia Wong, Brent P. Avery, Danielle Daignault, Michael R. Mulvey, Richard J. Reid‐Smith, E. Jane Parmley, Andrea Portt, Patrick Boerlin, Amee R. MangesList of authors in order
- Landing page
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https://doi.org/10.1093/ofid/ofz431Publisher landing page
- PDF URL
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https://academic.oup.com/ofid/article-pdf/6/11/ofz431/30341358/ofz431.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://academic.oup.com/ofid/article-pdf/6/11/ofz431/30341358/ofz431.pdfDirect OA link when available
- Concepts
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Multilocus sequence typing, Biology, Epidemiology, Escherichia coli, Genome, Genetics, Medicine, Gene, Genotype, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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38Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 3, 2023: 7, 2022: 8, 2021: 4Per-year citation counts (last 5 years)
- References (count)
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46Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5072754415, https://openalex.org/A5000909107, https://openalex.org/A5061958884, https://openalex.org/A5052831630 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I141945490, https://openalex.org/I2802940977 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6100000143051147 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.947151 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |