Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018 Article Swipe
YOU?
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· 2021
· Open Access
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· DOI: https://doi.org/10.1038/s41598-021-89070-1
Dengue virus is a major and rapidly growing public health concern in tropic and subtropic regions across the globe. In late 2018, Senegal experienced its largest dengue virus outbreak to date, covering several regions. However, little is known about the genetic diversity of dengue virus (DENV) in Senegal. Here we report complete viral genomes from 17 previously undetected DENV cases from the city of Thiès. In total we identified 19 cases of DENV in a cohort of 198 individuals with fever collected in October and November 2018. We detected 3 co-circulating serotypes; DENV 3 was the most frequent accounting for 11/17 sequences (65%), 4 (23%) were DENV2 and 2 (12%) were DENV1. Sequences were most similar to recent sequences from West Africa, suggesting ongoing local circulation of viral populations; however, detailed inference is limited by the scarcity of available genomic data. We did not find clear associations with reported clinical signs or symptoms, highlighting the importance of testing for diagnosing febrile diseases. Overall, these findings expand the known range of DENV in Senegal, and underscore the need for better genomic characterization of DENV in West Africa.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-021-89070-1
- https://www.nature.com/articles/s41598-021-89070-1.pdf
- OA Status
- gold
- Cited By
- 30
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3162988283
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3162988283Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41598-021-89070-1Digital Object Identifier
- Title
-
Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-05-14Full publication date if available
- Authors
-
Amy Gaye, Tolla Ndiaye, Mouhamad Sy, Awa B. Dème, Alphonse Thiaw, Aita Sene, Cheikh Ndiaye, Younouss Diédhiou, Amadou Moctar Mbaye, Ibrahima Ndiaye, Christopher H. Tomkins-Tinch, Jules F. Gomis, Aïda Sadikh Badiane, Bronwyn MacInnis, Daniel J. Park, Mouhamadou Ndiaye, Ngayo Sy, Pardis C. Sabeti, Katherine J. Siddle, Daouda NdiayeList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-021-89070-1Publisher landing page
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https://www.nature.com/articles/s41598-021-89070-1.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41598-021-89070-1.pdfDirect OA link when available
- Concepts
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Dengue fever, Dengue virus, Outbreak, Serotype, Virology, Biology, VirusTop concepts (fields/topics) attached by OpenAlex
- Cited by
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30Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 9, 2023: 7, 2022: 7, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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34Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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