Genomic variations in EBNA3C of EBV associate with posttransplant lymphoproliferative disorder Article Swipe
Eden M. Maloney
,
Vincent Busque
,
Sin Ting Hui
,
Jiaying Toh
,
Marcelo Fernández-Viña
,
Sheri M. Krams
,
Carlos O. Esquivel
,
Olivia M. Martinez
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1172/jci.insight.131644
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1172/jci.insight.131644
Epstein-Barr Virus (EBV) is a ubiquitous virus linked to a variety of lymphoid and epithelial malignancies. In solid organ and hematopoietic stem cell transplant recipients, EBV is causally associated with posttransplant lymphoproliferative disorder (PTLD), a group of heterogeneous lymphoid diseases. EBV+ B cell lymphomas that develop in the context of PTLD are generally attributed to the immunosuppression required to promote graft survival, but little is known regarding the role of EBV genome diversity in the development of malignancy. We deep-sequenced the EBV genome from the peripheral blood of 18 solid organ transplant recipients, including 6 PTLD patients. Sequences from 6 EBV+ spontaneous lymphoblastoid B cell lines (SLCL) were similarly analyzed. The EBV genome from PTLD patients had a significantly greater number of variations than EBV from transplant recipients without PTLD. Importantly, there were 15 nonsynonymous variations, including 8 in the latent cycle gene EBNA3C that were associated with the development of PTLD. One of the nonsynonymous variations in EBNA3C is located within a previously defined T cell epitope. These findings suggest that variations in the EBV genome can contribute to the pathogenesis of PTLD.
Related Topics
Concepts
Epstein–Barr virus
Lymphoproliferative disorders
Biology
Immunosuppression
Post-transplant lymphoproliferative disorder
Malignancy
Context (archaeology)
Immunology
Genome
Virus
Virology
Lymphoma
Gene
Genetics
Paleontology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1172/jci.insight.131644
- http://insight.jci.org/articles/view/131644/files/pdf
- OA Status
- gold
- Cited By
- 11
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3013427786
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3013427786Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1172/jci.insight.131644Digital Object Identifier
- Title
-
Genomic variations in EBNA3C of EBV associate with posttransplant lymphoproliferative disorderWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-03-25Full publication date if available
- Authors
-
Eden M. Maloney, Vincent Busque, Sin Ting Hui, Jiaying Toh, Marcelo Fernández-Viña, Sheri M. Krams, Carlos O. Esquivel, Olivia M. MartinezList of authors in order
- Landing page
-
https://doi.org/10.1172/jci.insight.131644Publisher landing page
- PDF URL
-
https://insight.jci.org/articles/view/131644/files/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://insight.jci.org/articles/view/131644/files/pdfDirect OA link when available
- Concepts
-
Epstein–Barr virus, Lymphoproliferative disorders, Biology, Immunosuppression, Post-transplant lymphoproliferative disorder, Malignancy, Context (archaeology), Immunology, Genome, Virus, Virology, Lymphoma, Gene, Genetics, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2, 2023: 4, 2022: 1, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
41Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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