Genotype-specific Features Reduce the Susceptibility of South American Yellow Fever Virus Strains to Vaccine-Induced Antibodies Article Swipe
Denise Haslwanter
,
Gorka Lasso
,
Anna Z. Wec
,
Nathália Dias Furtado
,
Lidiane Menezes Souza Raphael
,
Yan Sun
,
Stephanie Stransky
,
Núria Pedreño-López
,
Alexandra L. Tse
,
Carolina Argondizo Correia
,
Zachary A. Bornholdt
,
Mrunal Sakharkar
,
Vivian Iida Avelino‐Silva
,
Crystal L. Moyer
,
David I. Watkins
,
Esper G. Kallás
,
Simone Sidoli
,
Laura M. Walker
,
Myrna C. Bonaldo
,
Kartik Chandran
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.08.22.457235
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.08.22.457235
Summary The resurgence of yellow fever in South America has prompted mitigation through vaccination against the etiologic agent, yellow fever virus (YFV). Current vaccines are based on a virulent African isolate, and their capacity to induce neutralizing antibodies against the vaccine strain is widely used as a surrogate for protection. However, the sensitivity of genetically distinct South American strains to vaccine-induced antibodies is unknown. Here, we show that antiviral potency of the polyclonal antibody response in both U.S. and Brazilian vaccinees is attenuated against an emergent Brazilian strain. This reduction was attributable to genetic changes at two sites in the central domain II of the glycoprotein E, including the acquisition of an N –linked glycosylation site, which are unique to and shared among most South American YFV strains. Our findings call for a reevaluation of current approaches to YFV immunological surveillance in South America and suggest approaches for designing updated vaccines.
Related Topics
Concepts
Virology
Yellow fever
Yellow fever vaccine
Antibody
Virus
Biology
Genotype
Vaccination
Virulence
Polyclonal antibodies
Immunology
Gene
Genetics
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.08.22.457235
- https://www.biorxiv.org/content/biorxiv/early/2021/08/22/2021.08.22.457235.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 76
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3195981983
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3195981983Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2021.08.22.457235Digital Object Identifier
- Title
-
Genotype-specific Features Reduce the Susceptibility of South American Yellow Fever Virus Strains to Vaccine-Induced AntibodiesWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-08-22Full publication date if available
- Authors
-
Denise Haslwanter, Gorka Lasso, Anna Z. Wec, Nathália Dias Furtado, Lidiane Menezes Souza Raphael, Yan Sun, Stephanie Stransky, Núria Pedreño-López, Alexandra L. Tse, Carolina Argondizo Correia, Zachary A. Bornholdt, Mrunal Sakharkar, Vivian Iida Avelino‐Silva, Crystal L. Moyer, David I. Watkins, Esper G. Kallás, Simone Sidoli, Laura M. Walker, Myrna C. Bonaldo, Kartik ChandranList of authors in order
- Landing page
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https://doi.org/10.1101/2021.08.22.457235Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2021/08/22/2021.08.22.457235.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2021/08/22/2021.08.22.457235.full.pdfDirect OA link when available
- Concepts
-
Virology, Yellow fever, Yellow fever vaccine, Antibody, Virus, Biology, Genotype, Vaccination, Virulence, Polyclonal antibodies, Immunology, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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76Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5089260834, https://openalex.org/A5042192588 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 20 |
| corresponding_institution_ids | https://openalex.org/I129975664, https://openalex.org/I4210088923, https://openalex.org/I52325 |
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| sustainable_development_goals[0].display_name | Good health and well-being |
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| citation_normalized_percentile.is_in_top_10_percent | False |