Geometry Dynamics ofα-Helices in Different Class I Major Histocompatibility Complexes Article Swipe
Reiner Ribarics
,
Michael Kenn
,
Rudolf Karch
,
Nevena Ilieva
,
Wolfgang Schreiner
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1155/2015/173593
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1155/2015/173593
MHC α -helices form the antigen-binding cleft and are of particular interest for immunological reactions. To monitor these helices in molecular dynamics simulations, we applied a parsimonious fragment-fitting method to trace the axes of the α -helices. Each resulting axis was fitted by polynomials in a least-squares sense and the curvature integral was computed. To find the appropriate polynomial degree, the method was tested on two artificially modelled helices, one performing a bending movement and another a hinge movement. We found that second-order polynomials retrieve predefined parameters of helical motion with minimal relative error. From MD simulations we selected those parts of α -helices that were stable and also close to the TCR/MHC interface. We monitored the curvature integral, generated a ruled surface between the two MHC α -helices, and computed interhelical area and surface torsion, as they changed over time. We found that MHC α -helices undergo rapid but small changes in conformation. The curvature integral of helices proved to be a sensitive measure, which was closely related to changes in shape over time as confirmed by RMSD analysis. We speculate that small changes in the conformation of individual MHC α -helices are part of the intrinsic dynamics induced by engagement with the TCR.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2015/173593
- https://downloads.hindawi.com/journals/jir/2015/173593.pdf
- OA Status
- gold
- Cited By
- 3
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2123477542
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2123477542Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1155/2015/173593Digital Object Identifier
- Title
-
Geometry Dynamics ofα-Helices in Different Class I Major Histocompatibility ComplexesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-01-01Full publication date if available
- Authors
-
Reiner Ribarics, Michael Kenn, Rudolf Karch, Nevena Ilieva, Wolfgang SchreinerList of authors in order
- Landing page
-
https://doi.org/10.1155/2015/173593Publisher landing page
- PDF URL
-
https://downloads.hindawi.com/journals/jir/2015/173593.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://downloads.hindawi.com/journals/jir/2015/173593.pdfDirect OA link when available
- Concepts
-
Class (philosophy), Dynamics (music), Major histocompatibility complex, Geometry, Mathematics, Physics, Genetics, Biology, Computer science, Gene, Artificial intelligence, AcousticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2022: 2, 2019: 1Per-year citation counts (last 5 years)
- References (count)
-
43Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2123477542 |
|---|---|
| doi | https://doi.org/10.1155/2015/173593 |
| ids.doi | https://doi.org/10.1155/2015/173593 |
| ids.mag | 2123477542 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/26649324 |
| ids.openalex | https://openalex.org/W2123477542 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D001665 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Binding Sites |
| mesh[1].qualifier_ui | Q000737 |
| mesh[1].descriptor_ui | D015796 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | chemistry |
| mesh[1].descriptor_name | HLA-B27 Antigen |
| mesh[2].qualifier_ui | Q000276 |
| mesh[2].descriptor_ui | D015796 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | immunology |
| mesh[2].descriptor_name | HLA-B27 Antigen |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D006801 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Humans |
| mesh[4].qualifier_ui | Q000737 |
| mesh[4].descriptor_ui | D054992 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | chemistry |
| mesh[4].descriptor_name | Immunological Synapses |
| mesh[5].qualifier_ui | Q000276 |
| mesh[5].descriptor_ui | D054992 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | immunology |
| mesh[5].descriptor_name | Immunological Synapses |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D016018 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Least-Squares Analysis |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D056004 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Molecular Dynamics Simulation |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D009154 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Mutation |
| mesh[9].qualifier_ui | Q000737 |
| mesh[9].descriptor_ui | D010455 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | chemistry |
| mesh[9].descriptor_name | Peptides |
| mesh[10].qualifier_ui | Q000276 |
| mesh[10].descriptor_ui | D010455 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | immunology |
| mesh[10].descriptor_name | Peptides |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D011485 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Protein Binding |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D054730 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Protein Interaction Domains and Motifs |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D017433 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Protein Structure, Secondary |
| mesh[14].qualifier_ui | Q000737 |
| mesh[14].descriptor_ui | D011948 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | chemistry |
| mesh[14].descriptor_name | Receptors, Antigen, T-Cell |
| mesh[15].qualifier_ui | Q000276 |
| mesh[15].descriptor_ui | D011948 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | immunology |
| mesh[15].descriptor_name | Receptors, Antigen, T-Cell |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D001665 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Binding Sites |
| mesh[17].qualifier_ui | Q000737 |
| mesh[17].descriptor_ui | D015796 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | chemistry |
| mesh[17].descriptor_name | HLA-B27 Antigen |
| mesh[18].qualifier_ui | Q000276 |
| mesh[18].descriptor_ui | D015796 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | immunology |
| mesh[18].descriptor_name | HLA-B27 Antigen |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D006801 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Humans |
| mesh[20].qualifier_ui | Q000737 |
| mesh[20].descriptor_ui | D054992 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | chemistry |
| mesh[20].descriptor_name | Immunological Synapses |
| mesh[21].qualifier_ui | Q000276 |
| mesh[21].descriptor_ui | D054992 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | immunology |
| mesh[21].descriptor_name | Immunological Synapses |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D016018 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Least-Squares Analysis |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D056004 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Molecular Dynamics Simulation |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D009154 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Mutation |
| mesh[25].qualifier_ui | Q000737 |
| mesh[25].descriptor_ui | D010455 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | chemistry |
| mesh[25].descriptor_name | Peptides |
| mesh[26].qualifier_ui | Q000276 |
| mesh[26].descriptor_ui | D010455 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | immunology |
| mesh[26].descriptor_name | Peptides |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D011485 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Protein Binding |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D054730 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Protein Interaction Domains and Motifs |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D017433 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Protein Structure, Secondary |
| mesh[30].qualifier_ui | Q000737 |
| mesh[30].descriptor_ui | D011948 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | chemistry |
| mesh[30].descriptor_name | Receptors, Antigen, T-Cell |
| mesh[31].qualifier_ui | Q000276 |
| mesh[31].descriptor_ui | D011948 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | immunology |
| mesh[31].descriptor_name | Receptors, Antigen, T-Cell |
| type | article |
| title | Geometry Dynamics ofα-Helices in Different Class I Major Histocompatibility Complexes |
| biblio.issue | |
| biblio.volume | 2015 |
| biblio.last_page | 20 |
| biblio.first_page | 1 |
| topics[0].id | https://openalex.org/T10602 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9987000226974487 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Glycosylation and Glycoproteins Research |
| topics[1].id | https://openalex.org/T11041 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.998199999332428 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Ubiquitin and proteasome pathways |
| topics[2].id | https://openalex.org/T11162 |
| topics[2].field.id | https://openalex.org/fields/25 |
| topics[2].field.display_name | Materials Science |
| topics[2].score | 0.996999979019165 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2505 |
| topics[2].subfield.display_name | Materials Chemistry |
| topics[2].display_name | Enzyme Structure and Function |
| funders[0].id | https://openalex.org/F4320312143 |
| funders[0].ror | https://ror.org/03r10zj06 |
| funders[0].display_name | National Centre for Supercomputing Applications |
| is_xpac | False |
| apc_list.value | 2100 |
| apc_list.currency | USD |
| apc_list.value_usd | 2100 |
| apc_paid.value | 2100 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2100 |
| concepts[0].id | https://openalex.org/C2777212361 |
| concepts[0].level | 2 |
| concepts[0].score | 0.6063284277915955 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q5127848 |
| concepts[0].display_name | Class (philosophy) |
| concepts[1].id | https://openalex.org/C145912823 |
| concepts[1].level | 2 |
| concepts[1].score | 0.5415781140327454 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q113558 |
| concepts[1].display_name | Dynamics (music) |
| concepts[2].id | https://openalex.org/C207936829 |
| concepts[2].level | 3 |
| concepts[2].score | 0.45448729395866394 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q423163 |
| concepts[2].display_name | Major histocompatibility complex |
| concepts[3].id | https://openalex.org/C2524010 |
| concepts[3].level | 1 |
| concepts[3].score | 0.3788973093032837 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q8087 |
| concepts[3].display_name | Geometry |
| concepts[4].id | https://openalex.org/C33923547 |
| concepts[4].level | 0 |
| concepts[4].score | 0.33207958936691284 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q395 |
| concepts[4].display_name | Mathematics |
| concepts[5].id | https://openalex.org/C121332964 |
| concepts[5].level | 0 |
| concepts[5].score | 0.32962265610694885 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q413 |
| concepts[5].display_name | Physics |
| concepts[6].id | https://openalex.org/C54355233 |
| concepts[6].level | 1 |
| concepts[6].score | 0.281477153301239 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[6].display_name | Genetics |
| concepts[7].id | https://openalex.org/C86803240 |
| concepts[7].level | 0 |
| concepts[7].score | 0.2763484716415405 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[7].display_name | Biology |
| concepts[8].id | https://openalex.org/C41008148 |
| concepts[8].level | 0 |
| concepts[8].score | 0.14576798677444458 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[8].display_name | Computer science |
| concepts[9].id | https://openalex.org/C104317684 |
| concepts[9].level | 2 |
| concepts[9].score | 0.12093853950500488 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[9].display_name | Gene |
| concepts[10].id | https://openalex.org/C154945302 |
| concepts[10].level | 1 |
| concepts[10].score | 0.06169363856315613 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11660 |
| concepts[10].display_name | Artificial intelligence |
| concepts[11].id | https://openalex.org/C24890656 |
| concepts[11].level | 1 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q82811 |
| concepts[11].display_name | Acoustics |
| keywords[0].id | https://openalex.org/keywords/class |
| keywords[0].score | 0.6063284277915955 |
| keywords[0].display_name | Class (philosophy) |
| keywords[1].id | https://openalex.org/keywords/dynamics |
| keywords[1].score | 0.5415781140327454 |
| keywords[1].display_name | Dynamics (music) |
| keywords[2].id | https://openalex.org/keywords/major-histocompatibility-complex |
| keywords[2].score | 0.45448729395866394 |
| keywords[2].display_name | Major histocompatibility complex |
| keywords[3].id | https://openalex.org/keywords/geometry |
| keywords[3].score | 0.3788973093032837 |
| keywords[3].display_name | Geometry |
| keywords[4].id | https://openalex.org/keywords/mathematics |
| keywords[4].score | 0.33207958936691284 |
| keywords[4].display_name | Mathematics |
| keywords[5].id | https://openalex.org/keywords/physics |
| keywords[5].score | 0.32962265610694885 |
| keywords[5].display_name | Physics |
| keywords[6].id | https://openalex.org/keywords/genetics |
| keywords[6].score | 0.281477153301239 |
| keywords[6].display_name | Genetics |
| keywords[7].id | https://openalex.org/keywords/biology |
| keywords[7].score | 0.2763484716415405 |
| keywords[7].display_name | Biology |
| keywords[8].id | https://openalex.org/keywords/computer-science |
| keywords[8].score | 0.14576798677444458 |
| keywords[8].display_name | Computer science |
| keywords[9].id | https://openalex.org/keywords/gene |
| keywords[9].score | 0.12093853950500488 |
| keywords[9].display_name | Gene |
| keywords[10].id | https://openalex.org/keywords/artificial-intelligence |
| keywords[10].score | 0.06169363856315613 |
| keywords[10].display_name | Artificial intelligence |
| language | en |
| locations[0].id | doi:10.1155/2015/173593 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210178340 |
| locations[0].source.issn | 2314-7156, 2314-8861 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2314-7156 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Journal of Immunology Research |
| locations[0].source.host_organization | https://openalex.org/P4310319869 |
| locations[0].source.host_organization_name | Hindawi Publishing Corporation |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319869 |
| locations[0].source.host_organization_lineage_names | Hindawi Publishing Corporation |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://downloads.hindawi.com/journals/jir/2015/173593.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Immunology Research |
| locations[0].landing_page_url | https://doi.org/10.1155/2015/173593 |
| locations[1].id | pmid:26649324 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of immunology research |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/26649324 |
| locations[2].id | pmh:oai:doaj.org/article:8aa547bc6b3d4ba2ba36b3b12fd04579 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Journal of Immunology Research, Vol 2015 (2015) |
| locations[2].landing_page_url | https://doaj.org/article/8aa547bc6b3d4ba2ba36b3b12fd04579 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:4651647 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | http://doi.org/10.1155/2015/173593 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5050219581 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-5743-5166 |
| authorships[0].author.display_name | Reiner Ribarics |
| authorships[0].countries | AT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I76134821 |
| authorships[0].affiliations[0].raw_affiliation_string | Section of Biosimulation and Bioinformatics, Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria. |
| authorships[0].institutions[0].id | https://openalex.org/I76134821 |
| authorships[0].institutions[0].ror | https://ror.org/05n3x4p02 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I76134821 |
| authorships[0].institutions[0].country_code | AT |
| authorships[0].institutions[0].display_name | Medical University of Vienna |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Reiner Ribarics |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Section of Biosimulation and Bioinformatics, Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria. |
| authorships[1].author.id | https://openalex.org/A5015128268 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-8998-8005 |
| authorships[1].author.display_name | Michael Kenn |
| authorships[1].countries | AT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I76134821 |
| authorships[1].affiliations[0].raw_affiliation_string | Section of Biosimulation and Bioinformatics, Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria. |
| authorships[1].institutions[0].id | https://openalex.org/I76134821 |
| authorships[1].institutions[0].ror | https://ror.org/05n3x4p02 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I76134821 |
| authorships[1].institutions[0].country_code | AT |
| authorships[1].institutions[0].display_name | Medical University of Vienna |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Michael Kenn |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Section of Biosimulation and Bioinformatics, Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria. |
| authorships[2].author.id | https://openalex.org/A5009069767 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-1541-7215 |
| authorships[2].author.display_name | Rudolf Karch |
| authorships[2].countries | AT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I76134821 |
| authorships[2].affiliations[0].raw_affiliation_string | Section of Biosimulation and Bioinformatics, Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria. |
| authorships[2].institutions[0].id | https://openalex.org/I76134821 |
| authorships[2].institutions[0].ror | https://ror.org/05n3x4p02 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I76134821 |
| authorships[2].institutions[0].country_code | AT |
| authorships[2].institutions[0].display_name | Medical University of Vienna |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Rudolf Karch |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Section of Biosimulation and Bioinformatics, Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria. |
| authorships[3].author.id | https://openalex.org/A5084373333 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-2372-2319 |
| authorships[3].author.display_name | Nevena Ilieva |
| authorships[3].countries | BG |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I24768866 |
| authorships[3].affiliations[0].raw_affiliation_string | Institute of Information and Communication Technologies (IICT), Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 25A, 1113 Sofia, Bulgaria. |
| authorships[3].institutions[0].id | https://openalex.org/I24768866 |
| authorships[3].institutions[0].ror | https://ror.org/01x8hew03 |
| authorships[3].institutions[0].type | government |
| authorships[3].institutions[0].lineage | https://openalex.org/I24768866 |
| authorships[3].institutions[0].country_code | BG |
| authorships[3].institutions[0].display_name | Bulgarian Academy of Sciences |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Nevena Ilieva |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Institute of Information and Communication Technologies (IICT), Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 25A, 1113 Sofia, Bulgaria. |
| authorships[4].author.id | https://openalex.org/A5036250536 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-1910-5788 |
| authorships[4].author.display_name | Wolfgang Schreiner |
| authorships[4].countries | AT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I76134821 |
| authorships[4].affiliations[0].raw_affiliation_string | Section of Biosimulation and Bioinformatics, Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria. |
| authorships[4].institutions[0].id | https://openalex.org/I76134821 |
| authorships[4].institutions[0].ror | https://ror.org/05n3x4p02 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I76134821 |
| authorships[4].institutions[0].country_code | AT |
| authorships[4].institutions[0].display_name | Medical University of Vienna |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | Wolfgang Schreiner |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Section of Biosimulation and Bioinformatics, Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria. |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://downloads.hindawi.com/journals/jir/2015/173593.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2016-06-24T00:00:00 |
| display_name | Geometry Dynamics ofα-Helices in Different Class I Major Histocompatibility Complexes |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10602 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9987000226974487 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Glycosylation and Glycoproteins Research |
| related_works | https://openalex.org/W4391375266, https://openalex.org/W1979597421, https://openalex.org/W2007980826, https://openalex.org/W2061531152, https://openalex.org/W3002753104, https://openalex.org/W2077600819, https://openalex.org/W2142036596, https://openalex.org/W2072657027, https://openalex.org/W2962838298, https://openalex.org/W2600246793 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2022 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2019 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1155/2015/173593 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210178340 |
| best_oa_location.source.issn | 2314-7156, 2314-8861 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2314-7156 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Journal of Immunology Research |
| best_oa_location.source.host_organization | https://openalex.org/P4310319869 |
| best_oa_location.source.host_organization_name | Hindawi Publishing Corporation |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319869 |
| best_oa_location.source.host_organization_lineage_names | Hindawi Publishing Corporation |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://downloads.hindawi.com/journals/jir/2015/173593.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Immunology Research |
| best_oa_location.landing_page_url | https://doi.org/10.1155/2015/173593 |
| primary_location.id | doi:10.1155/2015/173593 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210178340 |
| primary_location.source.issn | 2314-7156, 2314-8861 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2314-7156 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Journal of Immunology Research |
| primary_location.source.host_organization | https://openalex.org/P4310319869 |
| primary_location.source.host_organization_name | Hindawi Publishing Corporation |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319869 |
| primary_location.source.host_organization_lineage_names | Hindawi Publishing Corporation |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://downloads.hindawi.com/journals/jir/2015/173593.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Immunology Research |
| primary_location.landing_page_url | https://doi.org/10.1155/2015/173593 |
| publication_date | 2015-01-01 |
| publication_year | 2015 |
| referenced_works | https://openalex.org/W2023276714, https://openalex.org/W2155740919, https://openalex.org/W2043080692, https://openalex.org/W2404769212, https://openalex.org/W2061806013, https://openalex.org/W2078254067, https://openalex.org/W2044406741, https://openalex.org/W1885675676, https://openalex.org/W2051848604, https://openalex.org/W2154857524, https://openalex.org/W2046978722, https://openalex.org/W2146652028, https://openalex.org/W2119728532, https://openalex.org/W2058206198, https://openalex.org/W2028129561, https://openalex.org/W2015897434, https://openalex.org/W2020017111, https://openalex.org/W2095113240, https://openalex.org/W2062799062, https://openalex.org/W2019076206, https://openalex.org/W2127522551, https://openalex.org/W1992874693, https://openalex.org/W2008708467, https://openalex.org/W2140992384, https://openalex.org/W2136567909, https://openalex.org/W2089171658, https://openalex.org/W2016823177, https://openalex.org/W2071704671, https://openalex.org/W1990718766, https://openalex.org/W2039077782, https://openalex.org/W2056766936, https://openalex.org/W2152645204, https://openalex.org/W2156393136, https://openalex.org/W2090648593, https://openalex.org/W1973709420, https://openalex.org/W1987046773, https://openalex.org/W2095502348, https://openalex.org/W2089528412, https://openalex.org/W1965334605, https://openalex.org/W2029667189, https://openalex.org/W2063831812, https://openalex.org/W2149808586, https://openalex.org/W2056034415 |
| referenced_works_count | 43 |
| abstract_inverted_index.a | 25, 45, 71, 76, 120, 162 |
| abstract_inverted_index.MD | 95 |
| abstract_inverted_index.To | 15, 54 |
| abstract_inverted_index.We | 79, 114, 141, 180 |
| abstract_inverted_index.as | 136, 175 |
| abstract_inverted_index.be | 161 |
| abstract_inverted_index.by | 42, 177, 200 |
| abstract_inverted_index.in | 19, 44, 152, 171, 185 |
| abstract_inverted_index.of | 9, 33, 87, 101, 157, 188, 195 |
| abstract_inverted_index.on | 64 |
| abstract_inverted_index.to | 29, 110, 160, 169 |
| abstract_inverted_index.we | 23, 97 |
| abstract_inverted_index.α | 1, 35, 102, 127, 145, 191 |
| abstract_inverted_index.MHC | 0, 126, 144, 190 |
| abstract_inverted_index.The | 154 |
| abstract_inverted_index.and | 7, 48, 74, 107, 129, 133 |
| abstract_inverted_index.are | 8, 193 |
| abstract_inverted_index.but | 149 |
| abstract_inverted_index.for | 12 |
| abstract_inverted_index.one | 69 |
| abstract_inverted_index.the | 4, 31, 34, 49, 56, 60, 111, 116, 124, 186, 196, 203 |
| abstract_inverted_index.two | 65, 125 |
| abstract_inverted_index.was | 40, 52, 62, 166 |
| abstract_inverted_index.Each | 37 |
| abstract_inverted_index.From | 94 |
| abstract_inverted_index.RMSD | 178 |
| abstract_inverted_index.TCR. | 204 |
| abstract_inverted_index.also | 108 |
| abstract_inverted_index.area | 132 |
| abstract_inverted_index.axes | 32 |
| abstract_inverted_index.axis | 39 |
| abstract_inverted_index.find | 55 |
| abstract_inverted_index.form | 3 |
| abstract_inverted_index.over | 139, 173 |
| abstract_inverted_index.part | 194 |
| abstract_inverted_index.that | 81, 104, 143, 182 |
| abstract_inverted_index.they | 137 |
| abstract_inverted_index.time | 174 |
| abstract_inverted_index.were | 105 |
| abstract_inverted_index.with | 90, 202 |
| abstract_inverted_index.cleft | 6 |
| abstract_inverted_index.close | 109 |
| abstract_inverted_index.found | 80, 142 |
| abstract_inverted_index.hinge | 77 |
| abstract_inverted_index.parts | 100 |
| abstract_inverted_index.rapid | 148 |
| abstract_inverted_index.ruled | 121 |
| abstract_inverted_index.sense | 47 |
| abstract_inverted_index.shape | 172 |
| abstract_inverted_index.small | 150, 183 |
| abstract_inverted_index.these | 17 |
| abstract_inverted_index.those | 99 |
| abstract_inverted_index.time. | 140 |
| abstract_inverted_index.trace | 30 |
| abstract_inverted_index.which | 165 |
| abstract_inverted_index.error. | 93 |
| abstract_inverted_index.fitted | 41 |
| abstract_inverted_index.method | 28, 61 |
| abstract_inverted_index.motion | 89 |
| abstract_inverted_index.proved | 159 |
| abstract_inverted_index.stable | 106 |
| abstract_inverted_index.tested | 63 |
| abstract_inverted_index.TCR/MHC | 112 |
| abstract_inverted_index.another | 75 |
| abstract_inverted_index.applied | 24 |
| abstract_inverted_index.bending | 72 |
| abstract_inverted_index.between | 123 |
| abstract_inverted_index.changed | 138 |
| abstract_inverted_index.changes | 151, 170, 184 |
| abstract_inverted_index.closely | 167 |
| abstract_inverted_index.degree, | 59 |
| abstract_inverted_index.helical | 88 |
| abstract_inverted_index.helices | 18, 158 |
| abstract_inverted_index.induced | 199 |
| abstract_inverted_index.minimal | 91 |
| abstract_inverted_index.monitor | 16 |
| abstract_inverted_index.related | 168 |
| abstract_inverted_index.surface | 122, 134 |
| abstract_inverted_index.undergo | 147 |
| abstract_inverted_index.-helices | 2, 103, 146, 192 |
| abstract_inverted_index.computed | 130 |
| abstract_inverted_index.dynamics | 21, 198 |
| abstract_inverted_index.helices, | 68 |
| abstract_inverted_index.integral | 51, 156 |
| abstract_inverted_index.interest | 11 |
| abstract_inverted_index.measure, | 164 |
| abstract_inverted_index.modelled | 67 |
| abstract_inverted_index.movement | 73 |
| abstract_inverted_index.relative | 92 |
| abstract_inverted_index.retrieve | 84 |
| abstract_inverted_index.selected | 98 |
| abstract_inverted_index.torsion, | 135 |
| abstract_inverted_index.-helices, | 128 |
| abstract_inverted_index.-helices. | 36 |
| abstract_inverted_index.analysis. | 179 |
| abstract_inverted_index.computed. | 53 |
| abstract_inverted_index.confirmed | 176 |
| abstract_inverted_index.curvature | 50, 117, 155 |
| abstract_inverted_index.generated | 119 |
| abstract_inverted_index.integral, | 118 |
| abstract_inverted_index.intrinsic | 197 |
| abstract_inverted_index.molecular | 20 |
| abstract_inverted_index.monitored | 115 |
| abstract_inverted_index.movement. | 78 |
| abstract_inverted_index.resulting | 38 |
| abstract_inverted_index.sensitive | 163 |
| abstract_inverted_index.speculate | 181 |
| abstract_inverted_index.engagement | 201 |
| abstract_inverted_index.individual | 189 |
| abstract_inverted_index.interface. | 113 |
| abstract_inverted_index.parameters | 86 |
| abstract_inverted_index.particular | 10 |
| abstract_inverted_index.performing | 70 |
| abstract_inverted_index.polynomial | 58 |
| abstract_inverted_index.predefined | 85 |
| abstract_inverted_index.reactions. | 14 |
| abstract_inverted_index.appropriate | 57 |
| abstract_inverted_index.polynomials | 43, 83 |
| abstract_inverted_index.simulations | 96 |
| abstract_inverted_index.artificially | 66 |
| abstract_inverted_index.conformation | 187 |
| abstract_inverted_index.interhelical | 131 |
| abstract_inverted_index.parsimonious | 26 |
| abstract_inverted_index.second-order | 82 |
| abstract_inverted_index.simulations, | 22 |
| abstract_inverted_index.conformation. | 153 |
| abstract_inverted_index.immunological | 13 |
| abstract_inverted_index.least-squares | 46 |
| abstract_inverted_index.antigen-binding | 5 |
| abstract_inverted_index.fragment-fitting | 27 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 5 |
| citation_normalized_percentile.value | 0.05056395 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |