German‐Austrian guideline on screening for anal dysplasia and anal carcinoma in people living with HIV Article Swipe
David Chromy
,
Felix Aigner
,
Jürgen C. Becker
,
Markus Bickel
,
Andrea Brunner
,
Johannes Claßen
,
Monika Hampl
,
Doris Helbig
,
Marcus Hentrich
,
Franc Hetzer
,
Christian Pieter Hoffmann
,
Johannes Jongen
,
Elmar A. Joura
,
Reinhard Kirnbauer
,
Alexander Kreuter
,
Gerold Felician Lang
,
Memo Mokhles
,
Frank Oellig
,
Mark Oette
,
Anja Potthoff
,
Andreas D. Rink
,
Andreas Salat
,
Axel J. Schmidt
,
Robert Siegel
,
Georg Stary
,
Ricardo Niklas Werner
,
Gerhard Weyandt
,
Ulrike Wieland
,
Stefan Essern
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/ddg.15719
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/ddg.15719
Summary People with HIV are up to 100 times more likely to develop anal carcinoma compared to the general population. Diagnosing and treating precursor lesions, specifically high‐grade anal dysplasia, can significantly reduce the risk of developing anal carcinoma. This S2k‐guideline outlines the factors that increase the likelihood of developing anal carcinoma and its precursors, including advancing age, a low CD4 + T‐lymphocyte nadir, active cigarette smoking, receptive anal intercourse, or persistent infection with high‐risk (HR) types of human papillomavirus (HPV). Screening is primarily recommended for all men who have sex with men (MSM) and transgender women with HIV starting at age 35, and all people with HIV starting at age 45. After inspection and digital anorectal examination, anal cytology is collected. An HR‐HPV test may be performed. If clinical abnormalities are present or if cytology shows “ASC‐US or worse”, a referral for high‐resolution anoscopy (HRA) is indicated. If lesions are found during HRA, a biopsy should be obtained. Anal intraepithelial neoplasia (AIN) grade‐III or AIN‐II p16‐positive correspond to high‐grade dysplasia and require treatment. The most strongly recommended therapeutic options are electrocautery, 85% trichloroacetic acid, and surgical excision. Finally, the guideline discusses how these screening recommendations can be applied to individuals without HIV.
Related Topics
Concepts
Medicine
Guideline
Dysplasia
Anal Carcinoma
Anal cancer
Gynecology
Population
Intraepithelial neoplasia
Dermatology
Internal medicine
Pathology
Cancer
Environmental health
Prostate
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/ddg.15719
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ddg.15719
- OA Status
- hybrid
- Cited By
- 5
- References
- 95
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410076869
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410076869Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/ddg.15719Digital Object Identifier
- Title
-
German‐Austrian guideline on screening for anal dysplasia and anal carcinoma in people living with HIVWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-05Full publication date if available
- Authors
-
David Chromy, Felix Aigner, Jürgen C. Becker, Markus Bickel, Andrea Brunner, Johannes Claßen, Monika Hampl, Doris Helbig, Marcus Hentrich, Franc Hetzer, Christian Pieter Hoffmann, Johannes Jongen, Elmar A. Joura, Reinhard Kirnbauer, Alexander Kreuter, Gerold Felician Lang, Memo Mokhles, Frank Oellig, Mark Oette, Anja Potthoff, Andreas D. Rink, Andreas Salat, Axel J. Schmidt, Robert Siegel, Georg Stary, Ricardo Niklas Werner, Gerhard Weyandt, Ulrike Wieland, Stefan EssernList of authors in order
- Landing page
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https://doi.org/10.1111/ddg.15719Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ddg.15719Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ddg.15719Direct OA link when available
- Concepts
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Medicine, Guideline, Dysplasia, Anal Carcinoma, Anal cancer, Gynecology, Population, Intraepithelial neoplasia, Dermatology, Internal medicine, Pathology, Cancer, Environmental health, ProstateTop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5Per-year citation counts (last 5 years)
- References (count)
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95Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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