Germline variation at 8q24 and prostate cancer risk in men of European ancestry Article Swipe

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Marco Matejcic , Edward J. Saunders , Tokhir Dadaev , Mark N. Brook , Kan Wang , Xiaoming Sheng , Ali Amin Al Olama , Fredrick R. Schumacher , Sue A. Ingles , Koveela Govindasami , Sara Benlloch , Sonja I. Berndt , Demetrius Albanes , Stella Koutros , Kenneth Muir , Victoria L. Stevens , S. M. Gapstur , Catherine M. Tangen , Jyotsna Batra , Judith A. Clements , Henrik Grönberg , Nora Pashayan , Johanna Schleutker , Alicja Wolk , Catharine West , Lorelei A. Mucci , Peter Kraft , Géraldine Cancel‐Tassin , Karina D. Sørensen , Lovise Mæhle , Eli Marie Grindedal , Sara S. Strom , David E. Neal , Freddie C. Hamdy , J L Donovan , R.C. Travis , Robert J. Hamilton , Barry S. Rosenstein , Yong‐Jie Lu , Graham G. Giles , Adam S. Kibel , Ana Vega , Jeannette T. Bensen , Manolis Kogevinas , Kathryn L. Penney , J.Y. Park , Janet L. Stanford , Cezary Cybulski , Børge G. Nordestgaard , Hermann Brenner , C. Maier , John Kim , Manuel R. Teixeira , Susan L. Neuhausen , Kim De Ruyck , Azad Hassan Abdul Razack , Lisa F. Newcomb , Davor Lessel , Radka Kaneva , Nawaid Usmani , Frank Claessens , Paul A. Townsend , M.G. Domínguez , Monique J. Roobol , F. Ménégaux , Kay‐Tee Khaw , Lisa Cannon‐Albright , Hardev Pandha , S. N. Thibodeau , Dan Schaid , The PRACTICAL Consortium , Fredrik Wiklund , Stephen J. Chanock , D.F. Easton , Rosalind A. Eeles , Z. Kote-Jara , David V. Conti , C.A. Haiman ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.17615/ejg2-ya10

Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10−15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62–4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.

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Prostate cancer Germline Variation (astronomy) Oncology Demography Medicine Cancer Biology Internal medicine Genetics Sociology Astrophysics Gene Physics

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Type: article
Language: en
Landing Page: https://doi.org/10.17615/ejg2-ya10
OA Status: green
Related Works: 10
OpenAlex ID: https://openalex.org/W4385889393

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DOI: https://doi.org/10.17615/ejg2-ya10

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Title: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

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Language: en

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Publication year: 2023

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Publication date: 2023-08-17

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Authors: Marco Matejcic, Edward J. Saunders, Tokhir Dadaev, Mark N. Brook, Kan Wang, Xiaoming Sheng, Ali Amin Al Olama, Fredrick R. Schumacher, Sue A. Ingles, Koveela Govindasami, Sara Benlloch, Sonja I. Berndt, Demetrius Albanes, Stella Koutros, Kenneth Muir, Victoria L. Stevens, S. M. Gapstur, Catherine M. Tangen, Jyotsna Batra, Judith A. Clements, Henrik Grönberg, Nora Pashayan, Johanna Schleutker, Alicja Wolk, Catharine West, Lorelei A. Mucci, Peter Kraft, Géraldine Cancel‐Tassin, Karina D. Sørensen, Lovise Mæhle, Eli Marie Grindedal, Sara S. Strom, David E. Neal, Freddie C. Hamdy, J L Donovan, R.C. Travis, Robert J. Hamilton, Barry S. Rosenstein, Yong‐Jie Lu, Graham G. Giles, Adam S. Kibel, Ana Vega, Jeannette T. Bensen, Manolis Kogevinas, Kathryn L. Penney, J.Y. Park, Janet L. Stanford, Cezary Cybulski, Børge G. Nordestgaard, Hermann Brenner, C. Maier, John Kim, Manuel R. Teixeira, Susan L. Neuhausen, Kim De Ruyck, Azad Hassan Abdul Razack, Lisa F. Newcomb, Davor Lessel, Radka Kaneva, Nawaid Usmani, Frank Claessens, Paul A. Townsend, M.G. Domínguez, Monique J. Roobol, F. Ménégaux, Kay‐Tee Khaw, Lisa Cannon‐Albright, Hardev Pandha, S. N. Thibodeau, Dan Schaid, The PRACTICAL Consortium, Fredrik Wiklund, Stephen J. Chanock, D.F. Easton, Rosalind A. Eeles, Z. Kote-Jara, David V. Conti, C.A. Haiman

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Concepts: Prostate cancer, Germline, Variation (astronomy), Oncology, Demography, Medicine, Cancer, Biology, Internal medicine, Genetics, Sociology, Astrophysics, Gene, Physics

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