Gilteritinib overcomes primary resistance to venetoclax in a patient with FLT3 wild-type refractory/relapsed AML: Case report and exploration of possible mechanisms Article Swipe
Man Li
,
Xiawan Yang
,
Yaonan Hong
,
Qi Liu
,
Yingying Shen
,
Tonglin Hu
,
Yiping Shen
,
Guoyin Kai
,
Dijiong Wu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.heliyon.2024.e35847
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.heliyon.2024.e35847
Venetoclax, a selective BCL-2 inhibitor, has shown superior efficacy in the treatment of AML. Nevertheless, some AML patients with AML1-ETO respond poorly to venetoclax treatment. In this report, a relapsed/refractory (R/R) venetoclax resistant AML1-ETO positive AML patient showed rapid tumor regression after combination therapy with gilteritinib and venetoclax. Additional laboratory findings indicated that the combined impact of the two drugs may be associated with the induction of the integrated stress response. This case presents a novel therapeutic approach for the treatment of FLT3 wild-type RR, AML1-ETO AML patients who have primary resistance to venetoclax.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.heliyon.2024.e35847
- OA Status
- gold
- Cited By
- 1
- References
- 11
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401479663
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4401479663Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.heliyon.2024.e35847Digital Object Identifier
- Title
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Gilteritinib overcomes primary resistance to venetoclax in a patient with FLT3 wild-type refractory/relapsed AML: Case report and exploration of possible mechanismsWork title
- Type
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articleOpenAlex work type
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enPrimary language
- Publication year
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2024Year of publication
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2024-08-01Full publication date if available
- Authors
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Man Li, Xiawan Yang, Yaonan Hong, Qi Liu, Yingying Shen, Tonglin Hu, Yiping Shen, Guoyin Kai, Dijiong WuList of authors in order
- Landing page
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https://doi.org/10.1016/j.heliyon.2024.e35847Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.heliyon.2024.e35847Direct OA link when available
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Venetoclax, Refractory (planetary science), Medicine, Resistance (ecology), Cancer research, Biology, Leukemia, Internal medicine, Chronic lymphocytic leukemia, Ecology, AstrobiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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11Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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