Globus pallidus internus activity increases during voluntary movement in children with dystonia Article Swipe
Estefanía Hernández‐Martín
,
Maral Kasiri
,
Sumiko Abe
,
Jennifer MacLean
,
Joffre Olaya
,
Mark A. Liker
,
Jason Chu
,
Terence D. Sanger
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.isci.2023.107066
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.isci.2023.107066
The rate model of basal ganglia function predicts that muscle activity in dystonia is due to disinhibition of thalamus resulting from decreased inhibitory input from pallidum. We seek to test this hypothesis in children with dyskinetic cerebral palsy undergoing evaluation for deep brain stimulation (DBS) to analyze movement-related activity in different brain regions. The results revealed prominent beta-band frequency peaks in the globus pallidus interna (GPi), ventral oralis anterior/posterior (VoaVop) subnuclei of the thalamus, and subthalamic nucleus (STN) during movement but not at rest. Connectivity analysis indicated stronger coupling between STN-VoaVop and STN-GPi compared to GPi-STN. These findings contradict the hypothesis of decreased thalamic inhibition in dystonia, suggesting that abnormal patterns of inhibition and disinhibition, rather than reduced GPi activity, contribute to the disorder. Additionally, the study implies that correcting abnormalities in GPi function may explain the effectiveness of DBS targeting the STN and GPi in treating dystonia.
Related Topics
Concepts
Disinhibition
Subthalamic nucleus
Dystonia
Deep brain stimulation
Basal ganglia
Globus pallidus
Thalamus
Neuroscience
Movement disorders
Focal dystonia
Psychology
Premovement neuronal activity
Medicine
Central nervous system
Internal medicine
Parkinson's disease
Disease
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.isci.2023.107066
- OA Status
- gold
- Cited By
- 9
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4379743464
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4379743464Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.isci.2023.107066Digital Object Identifier
- Title
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Globus pallidus internus activity increases during voluntary movement in children with dystoniaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-06-07Full publication date if available
- Authors
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Estefanía Hernández‐Martín, Maral Kasiri, Sumiko Abe, Jennifer MacLean, Joffre Olaya, Mark A. Liker, Jason Chu, Terence D. SangerList of authors in order
- Landing page
-
https://doi.org/10.1016/j.isci.2023.107066Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.isci.2023.107066Direct OA link when available
- Concepts
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Disinhibition, Subthalamic nucleus, Dystonia, Deep brain stimulation, Basal ganglia, Globus pallidus, Thalamus, Neuroscience, Movement disorders, Focal dystonia, Psychology, Premovement neuronal activity, Medicine, Central nervous system, Internal medicine, Parkinson's disease, DiseaseTop concepts (fields/topics) attached by OpenAlex
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9Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 2, 2023: 2Per-year citation counts (last 5 years)
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66Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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