Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases Article Swipe
Maddalena Grieco
,
Alessandra Giorgi
,
Maria Cristina Gentile
,
Maria D’Erme
,
Susanna Morano
,
Bruno Maras
,
Tiziana Filardi
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3389/fnins.2019.01112
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3389/fnins.2019.01112
Diabetes mellitus is one of the major risk factors for cognitive dysfunction. The pathogenesis of brain impairment caused by chronic hyperglycemia is complex and includes mitochondrial dysfunction, neuroinflammation, neurotransmitters' alteration, and vascular disease, which lead to cognitive impairment, neurodegeneration, loss of synaptic plasticity, brain aging, and dementia. Glucagon-like peptide-1 (GLP-1), a gut released hormone, is attracting attention as a possible link between metabolic and brain impairment. Several studies have shown the influence of GPL-1 on neuronal functions such as thermogenesis, blood pressure control, neurogenesis, neurodegeneration, retinal repair, and energy homeostasis. Moreover, modulation of GLP-1 activity can influence amyloid β peptide aggregation in Alzheimer's disease (AD) and dopamine (DA) levels in Parkinson's disease (PD). GLP-1 receptor agonists (GLP-1RAs) showed beneficial actions on brain ischemia in animal models, such as the reduction of cerebral infarct area and the improvement of neurological deficit, acting mainly through inhibition of oxidative stress, inflammation, and apoptosis. They might also exert a beneficial effect on the cognitive impairment induced by diabetes or obesity improving learning and memory by modulating synaptic plasticity. Moreover, GLP-1RAs reduced hippocampal neurodegeneration. Besides this, there are growing evidences on neuroprotective effects of these agonists in animal models of neurodegenerative diseases, regardless of diabetes. In PD animal models, GPL-1RAs were able to protect motor activity and dopaminergic neurons whereas in AD models, they seemed to improve nearly all neuropathological features and cognitive functions. Although further clinical studies of GPL-1RAs in humans are needed, they seem to be a promising therapy for diabetes-associated cognitive decline.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnins.2019.01112
- https://www.frontiersin.org/articles/10.3389/fnins.2019.01112/pdf
- OA Status
- gold
- Cited By
- 192
- References
- 75
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2980881483
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2980881483Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fnins.2019.01112Digital Object Identifier
- Title
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Glucagon-Like Peptide-1: A Focus on Neurodegenerative DiseasesWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
-
2019-10-18Full publication date if available
- Authors
-
Maddalena Grieco, Alessandra Giorgi, Maria Cristina Gentile, Maria D’Erme, Susanna Morano, Bruno Maras, Tiziana FilardiList of authors in order
- Landing page
-
https://doi.org/10.3389/fnins.2019.01112Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fnins.2019.01112/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fnins.2019.01112/pdfDirect OA link when available
- Concepts
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Focus (optics), Neuroscience, Glucagon-like peptide-1, Peptide, Glucagon-like peptide-2, Medicine, Psychology, Chemistry, Diabetes mellitus, Endocrinology, Biochemistry, Physics, Type 2 diabetes, OpticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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192Total citation count in OpenAlex
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2025: 28, 2024: 37, 2023: 28, 2022: 39, 2021: 35Per-year citation counts (last 5 years)
- References (count)
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75Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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