Glucose is a positive modulator for the activation of human recombinant glycine receptors Article Swipe
Ulrike Breitinger
,
Karim Raafat
,
Hans‐Georg Breitinger
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1111/jnc.13215
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1111/jnc.13215
The inhibitory glycine receptor (GlyR), a cys–loop ion channel receptor, mediates rapid synaptic inhibition in spinal cord, brainstem and higher centres of the mammalian central nervous system. Here, modulation of GlyR function by glucose and fructose was examined in recombinant alpha1 and alpha1/beta GlyRs using patch‐clamp methods. Glucose was a positive modulator of the receptor, reducing the average EC 50 for glycine up to 4.5‐fold. Glucose reduced cell‐to‐cell variability of glycine‐mediated currents by stabilizing receptors with low EC 50 . Pre‐incubation with sugars for several hours also produced augmentation of current responses that persisted after sugar removal. Potentiation by sugars was most significant in the range between 5 and 20 mM, with EC 50 values ~ 10 mM, i.e. at physiological levels. Addition of glucose had no significant influence on responses mediated by the other GlyR agonists like taurine, β‐alanine or ivermectin, indicating that glucose specifically augmented glycine receptor‐mediated responses, and did not act through indirect metabolic effects. Receptor modulation by glucose may account for differences in constants reported in the literature and may be clinically relevant for disorders with elevated blood glucose levels. image Glucose and related sugars are essential metabolites. We identified glucose and fructose as positive modulators of the human inhibitory glycine receptor, a neuronal ligand‐gated ion channel. Receptor‐mediated currents were enhanced at physiological concentrations (~ 10 mM of sugar). Direct modulation of a synaptic receptor by glucose is relevant in clinical cases of elevated blood glucose, and may be considered in experimental protocols.
Related Topics
Concepts
Glycine receptor
Receptor
Glycine
Fructose
Chemistry
Inhibitory postsynaptic potential
Internal medicine
Endocrinology
Taurine
Ligand-gated ion channel
Biochemistry
Biology
Ion channel
Amino acid
Medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/jnc.13215
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jnc.13215
- OA Status
- bronze
- Cited By
- 21
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W1551426439
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W1551426439Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/jnc.13215Digital Object Identifier
- Title
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Glucose is a positive modulator for the activation of human recombinant glycine receptorsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2015Year of publication
- Publication date
-
2015-06-27Full publication date if available
- Authors
-
Ulrike Breitinger, Karim Raafat, Hans‐Georg BreitingerList of authors in order
- Landing page
-
https://doi.org/10.1111/jnc.13215Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jnc.13215Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jnc.13215Direct OA link when available
- Concepts
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Glycine receptor, Receptor, Glycine, Fructose, Chemistry, Inhibitory postsynaptic potential, Internal medicine, Endocrinology, Taurine, Ligand-gated ion channel, Biochemistry, Biology, Ion channel, Amino acid, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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21Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2023: 1, 2022: 1, 2021: 1, 2020: 8Per-year citation counts (last 5 years)
- References (count)
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44Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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