Journal of Cellular and Molecular Medicine • Vol 28 • No 7
Glutamine metabolism prognostic index predicts tumour microenvironment characteristics and therapeutic efficacy in ovarian cancer
March 2024 • Lingling Gao, Zheng Wei, Feiquan Ying, Huang Lin, Jingni Zhang, Si Sun, Zehua Wang, Jing Cai, Yuan Zhang
Abstract Mounting evidence has highlighted the multifunctional characteristics of glutamine metabolism (GM) in cancer initiation, progression and therapeutic regimens. However, the overall role of GM in the tumour microenvironment (TME), clinical stratification and therapeutic efficacy in patients with ovarian cancer (OC) has not been fully elucidated. Here, three distinct GM clusters were identified and exhibited different prognostic values, biological functions and immune infiltration in TME. Subsequently, gluta…