GMP Synthetase: Allostery, Structure, and Function Article Swipe
Lionel Ballut
,
Sébastien Violot
,
Sanjeev Kumar
,
N. Aghajari
,
Hemalatha Balaram
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/biom13091379
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/biom13091379
Glutamine amidotransferases (GATs) catalyze the hydrolysis of glutamine and transfer the generated ammonia to diverse metabolites. The two catalytic activities, glutaminolysis and the subsequent amination of the acceptor substrate, happen in two distinct catalytic pockets connected by a channel that facilitates the movement of ammonia. The de novo pathway for the synthesis of guanosine monophosphate (GMP) from xanthosine monophosphate (XMP) is enabled by the GAT GMP synthetase (GMPS). In most available crystal structures of GATs, the ammonia channel is evident in their native state or upon ligand binding, providing molecular details of the conduit. In addition, conformational changes that enable the coordination of the two catalytic chemistries are also informed by the available structures. In contrast, despite the first structure of a GMPS being published in 1996, the understanding of catalysis in the acceptor domain and inter-domain crosstalk became possible only after the structure of a glutamine-bound mutant of Plasmodium falciparum GMPS was determined. In this review, we present the current status of our understanding of the molecular basis of catalysis in GMPS, becoming the first comprehensive assessment of the biochemical function of this intriguing enzyme.
Related Topics
Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/biom13091379
- https://www.mdpi.com/2218-273X/13/9/1379/pdf?version=1694498702
- OA Status
- gold
- Cited By
- 11
- References
- 68
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386638162
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4386638162Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/biom13091379Digital Object Identifier
- Title
-
GMP Synthetase: Allostery, Structure, and FunctionWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-09-12Full publication date if available
- Authors
-
Lionel Ballut, Sébastien Violot, Sanjeev Kumar, N. Aghajari, Hemalatha BalaramList of authors in order
- Landing page
-
https://doi.org/10.3390/biom13091379Publisher landing page
- PDF URL
-
https://www.mdpi.com/2218-273X/13/9/1379/pdf?version=1694498702Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2218-273X/13/9/1379/pdf?version=1694498702Direct OA link when available
- Concepts
-
Allosteric regulation, Chemistry, Adenylylation, Amination, Guanosine, Biochemistry, Enzyme, Combinatorial chemistry, Catalysis, BiosynthesisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 8, 2024: 3Per-year citation counts (last 5 years)
- References (count)
-
68Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4386638162 |
|---|---|
| doi | https://doi.org/10.3390/biom13091379 |
| ids.doi | https://doi.org/10.3390/biom13091379 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/37759779 |
| ids.openalex | https://openalex.org/W4386638162 |
| fwci | 2.04237448 |
| type | review |
| title | GMP Synthetase: Allostery, Structure, and Function |
| biblio.issue | 9 |
| biblio.volume | 13 |
| biblio.last_page | 1379 |
| biblio.first_page | 1379 |
| topics[0].id | https://openalex.org/T12827 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Biochemical and Molecular Research |
| topics[1].id | https://openalex.org/T10526 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9973999857902527 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2725 |
| topics[1].subfield.display_name | Infectious Diseases |
| topics[1].display_name | HIV/AIDS drug development and treatment |
| is_xpac | False |
| apc_list.value | 2100 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2273 |
| apc_paid.value | 2100 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2273 |
| concepts[0].id | https://openalex.org/C166342909 |
| concepts[0].level | 3 |
| concepts[0].score | 0.671991229057312 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q845326 |
| concepts[0].display_name | Allosteric regulation |
| concepts[1].id | https://openalex.org/C185592680 |
| concepts[1].level | 0 |
| concepts[1].score | 0.6360703706741333 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[1].display_name | Chemistry |
| concepts[2].id | https://openalex.org/C160403918 |
| concepts[2].level | 4 |
| concepts[2].score | 0.605825662612915 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q4682322 |
| concepts[2].display_name | Adenylylation |
| concepts[3].id | https://openalex.org/C198503264 |
| concepts[3].level | 3 |
| concepts[3].score | 0.6032050251960754 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q471635 |
| concepts[3].display_name | Amination |
| concepts[4].id | https://openalex.org/C2777995097 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4684329926967621 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q422462 |
| concepts[4].display_name | Guanosine |
| concepts[5].id | https://openalex.org/C55493867 |
| concepts[5].level | 1 |
| concepts[5].score | 0.4636327922344208 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[5].display_name | Biochemistry |
| concepts[6].id | https://openalex.org/C181199279 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4131878614425659 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q8047 |
| concepts[6].display_name | Enzyme |
| concepts[7].id | https://openalex.org/C21951064 |
| concepts[7].level | 1 |
| concepts[7].score | 0.343738317489624 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q899212 |
| concepts[7].display_name | Combinatorial chemistry |
| concepts[8].id | https://openalex.org/C161790260 |
| concepts[8].level | 2 |
| concepts[8].score | 0.3159865736961365 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q82264 |
| concepts[8].display_name | Catalysis |
| concepts[9].id | https://openalex.org/C553450214 |
| concepts[9].level | 3 |
| concepts[9].score | 0.1894814372062683 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q851162 |
| concepts[9].display_name | Biosynthesis |
| keywords[0].id | https://openalex.org/keywords/allosteric-regulation |
| keywords[0].score | 0.671991229057312 |
| keywords[0].display_name | Allosteric regulation |
| keywords[1].id | https://openalex.org/keywords/chemistry |
| keywords[1].score | 0.6360703706741333 |
| keywords[1].display_name | Chemistry |
| keywords[2].id | https://openalex.org/keywords/adenylylation |
| keywords[2].score | 0.605825662612915 |
| keywords[2].display_name | Adenylylation |
| keywords[3].id | https://openalex.org/keywords/amination |
| keywords[3].score | 0.6032050251960754 |
| keywords[3].display_name | Amination |
| keywords[4].id | https://openalex.org/keywords/guanosine |
| keywords[4].score | 0.4684329926967621 |
| keywords[4].display_name | Guanosine |
| keywords[5].id | https://openalex.org/keywords/biochemistry |
| keywords[5].score | 0.4636327922344208 |
| keywords[5].display_name | Biochemistry |
| keywords[6].id | https://openalex.org/keywords/enzyme |
| keywords[6].score | 0.4131878614425659 |
| keywords[6].display_name | Enzyme |
| keywords[7].id | https://openalex.org/keywords/combinatorial-chemistry |
| keywords[7].score | 0.343738317489624 |
| keywords[7].display_name | Combinatorial chemistry |
| keywords[8].id | https://openalex.org/keywords/catalysis |
| keywords[8].score | 0.3159865736961365 |
| keywords[8].display_name | Catalysis |
| keywords[9].id | https://openalex.org/keywords/biosynthesis |
| keywords[9].score | 0.1894814372062683 |
| keywords[9].display_name | Biosynthesis |
| language | en |
| locations[0].id | doi:10.3390/biom13091379 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210236520 |
| locations[0].source.issn | 2218-273X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2218-273X |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Biomolecules |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2218-273X/13/9/1379/pdf?version=1694498702 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Biomolecules |
| locations[0].landing_page_url | https://doi.org/10.3390/biom13091379 |
| locations[1].id | pmid:37759779 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Biomolecules |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/37759779 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10526850 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10526850/pdf/biomolecules-13-01379.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Biomolecules |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10526850 |
| locations[3].id | pmh:oai:HAL:hal-04285650v1 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306402512 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[3].source.host_organization | https://openalex.org/I1294671590 |
| locations[3].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[3].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Journal articles |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Biomolecules, 2023, 13 (9), pp.1379. ⟨10.3390/biom13091379⟩ |
| locations[3].landing_page_url | https://hal.science/hal-04285650 |
| locations[4].id | pmh:oai:doaj.org/article:5a3aae29cbd946cca8fb443e007b5f3a |
| locations[4].is_oa | False |
| locations[4].source.id | https://openalex.org/S4306401280 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Biomolecules, Vol 13, Iss 9, p 1379 (2023) |
| locations[4].landing_page_url | https://doaj.org/article/5a3aae29cbd946cca8fb443e007b5f3a |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5002408630 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-3982-9321 |
| authorships[0].author.display_name | Lionel Ballut |
| authorships[0].countries | FR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I100532134, https://openalex.org/I1294671590 |
| authorships[0].affiliations[0].raw_affiliation_string | Molecular Microbiology and Structural Biochemistry, CNRS, University of Lyon1, UMR5086, 7 Passage du Vercors, CEDEX 07, F-69367 Lyon, France |
| authorships[0].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[0].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[0].institutions[0].type | government |
| authorships[0].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[0].institutions[0].country_code | FR |
| authorships[0].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[0].institutions[1].id | https://openalex.org/I100532134 |
| authorships[0].institutions[1].ror | https://ror.org/029brtt94 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I100532134, https://openalex.org/I203339264 |
| authorships[0].institutions[1].country_code | FR |
| authorships[0].institutions[1].display_name | Université Claude Bernard Lyon 1 |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Lionel Ballut |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Molecular Microbiology and Structural Biochemistry, CNRS, University of Lyon1, UMR5086, 7 Passage du Vercors, CEDEX 07, F-69367 Lyon, France |
| authorships[1].author.id | https://openalex.org/A5008139941 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-7749-9207 |
| authorships[1].author.display_name | Sébastien Violot |
| authorships[1].countries | FR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I100532134, https://openalex.org/I1294671590 |
| authorships[1].affiliations[0].raw_affiliation_string | Molecular Microbiology and Structural Biochemistry, CNRS, University of Lyon1, UMR5086, 7 Passage du Vercors, CEDEX 07, F-69367 Lyon, France |
| authorships[1].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[1].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[1].institutions[0].type | government |
| authorships[1].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[1].institutions[0].country_code | FR |
| authorships[1].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[1].institutions[1].id | https://openalex.org/I100532134 |
| authorships[1].institutions[1].ror | https://ror.org/029brtt94 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I100532134, https://openalex.org/I203339264 |
| authorships[1].institutions[1].country_code | FR |
| authorships[1].institutions[1].display_name | Université Claude Bernard Lyon 1 |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Sébastien Violot |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Molecular Microbiology and Structural Biochemistry, CNRS, University of Lyon1, UMR5086, 7 Passage du Vercors, CEDEX 07, F-69367 Lyon, France |
| authorships[2].author.id | https://openalex.org/A5102005219 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-6653-0467 |
| authorships[2].author.display_name | Sanjeev Kumar |
| authorships[2].countries | IN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I347237974 |
| authorships[2].affiliations[0].raw_affiliation_string | Trivedi School of Biosciences, Ashoka University, Rajiv Gandhi Education City, Sonipat 131029, Haryana, India |
| authorships[2].institutions[0].id | https://openalex.org/I347237974 |
| authorships[2].institutions[0].ror | https://ror.org/02j1xr113 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I347237974 |
| authorships[2].institutions[0].country_code | IN |
| authorships[2].institutions[0].display_name | Ashoka University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Sanjeev Kumar |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Trivedi School of Biosciences, Ashoka University, Rajiv Gandhi Education City, Sonipat 131029, Haryana, India |
| authorships[3].author.id | https://openalex.org/A5008336818 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-2245-2679 |
| authorships[3].author.display_name | N. Aghajari |
| authorships[3].countries | FR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I100532134, https://openalex.org/I1294671590 |
| authorships[3].affiliations[0].raw_affiliation_string | Molecular Microbiology and Structural Biochemistry, CNRS, University of Lyon1, UMR5086, 7 Passage du Vercors, CEDEX 07, F-69367 Lyon, France |
| authorships[3].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[3].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[3].institutions[0].type | government |
| authorships[3].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[3].institutions[1].id | https://openalex.org/I100532134 |
| authorships[3].institutions[1].ror | https://ror.org/029brtt94 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I100532134, https://openalex.org/I203339264 |
| authorships[3].institutions[1].country_code | FR |
| authorships[3].institutions[1].display_name | Université Claude Bernard Lyon 1 |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Nushin Aghajari |
| authorships[3].is_corresponding | True |
| authorships[3].raw_affiliation_strings | Molecular Microbiology and Structural Biochemistry, CNRS, University of Lyon1, UMR5086, 7 Passage du Vercors, CEDEX 07, F-69367 Lyon, France |
| authorships[4].author.id | https://openalex.org/A5024273182 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-8821-1288 |
| authorships[4].author.display_name | Hemalatha Balaram |
| authorships[4].countries | IN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I147481903 |
| authorships[4].affiliations[0].raw_affiliation_string | Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur 560064, Bangalore, India |
| authorships[4].institutions[0].id | https://openalex.org/I147481903 |
| authorships[4].institutions[0].ror | https://ror.org/0538gdx71 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I147481903, https://openalex.org/I2799351866, https://openalex.org/I4210098748, https://openalex.org/I4210134808 |
| authorships[4].institutions[0].country_code | IN |
| authorships[4].institutions[0].display_name | Jawaharlal Nehru Centre for Advanced Scientific Research |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | Hemalatha Balaram |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur 560064, Bangalore, India |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2218-273X/13/9/1379/pdf?version=1694498702 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | GMP Synthetase: Allostery, Structure, and Function |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12827 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Biochemical and Molecular Research |
| related_works | https://openalex.org/W1833436210, https://openalex.org/W2136087866, https://openalex.org/W2080160082, https://openalex.org/W2031635937, https://openalex.org/W2422809474, https://openalex.org/W2046450796, https://openalex.org/W2939998722, https://openalex.org/W2169750653, https://openalex.org/W2195592873, https://openalex.org/W1971782741 |
| cited_by_count | 11 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 8 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 3 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3390/biom13091379 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210236520 |
| best_oa_location.source.issn | 2218-273X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2218-273X |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Biomolecules |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2218-273X/13/9/1379/pdf?version=1694498702 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Biomolecules |
| best_oa_location.landing_page_url | https://doi.org/10.3390/biom13091379 |
| primary_location.id | doi:10.3390/biom13091379 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210236520 |
| primary_location.source.issn | 2218-273X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2218-273X |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Biomolecules |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2218-273X/13/9/1379/pdf?version=1694498702 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Biomolecules |
| primary_location.landing_page_url | https://doi.org/10.3390/biom13091379 |
| publication_date | 2023-09-12 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2736273628, https://openalex.org/W2800834635, https://openalex.org/W1986127063, https://openalex.org/W2142403678, https://openalex.org/W1911508635, https://openalex.org/W2092806983, https://openalex.org/W2570203573, https://openalex.org/W2151260851, https://openalex.org/W181453810, https://openalex.org/W2194856489, https://openalex.org/W3203907782, https://openalex.org/W1995220845, https://openalex.org/W3126733812, https://openalex.org/W2072095756, https://openalex.org/W2951505772, https://openalex.org/W2129750560, https://openalex.org/W2037239543, https://openalex.org/W2103578267, https://openalex.org/W1980300257, https://openalex.org/W2114410768, https://openalex.org/W1615043005, https://openalex.org/W72913968, https://openalex.org/W2090333491, https://openalex.org/W2146228523, https://openalex.org/W6777633549, https://openalex.org/W6808003216, https://openalex.org/W2043325514, https://openalex.org/W1595398565, https://openalex.org/W2090736922, https://openalex.org/W1964511715, https://openalex.org/W2061363929, https://openalex.org/W2218240001, https://openalex.org/W4283386652, https://openalex.org/W2029903665, https://openalex.org/W1866992734, https://openalex.org/W2035248081, https://openalex.org/W4293567340, https://openalex.org/W1980362937, https://openalex.org/W2093625241, https://openalex.org/W2093299882, https://openalex.org/W2053623997, https://openalex.org/W2043873350, https://openalex.org/W4210411013, https://openalex.org/W2131101297, https://openalex.org/W1999977530, https://openalex.org/W1986043138, https://openalex.org/W1995129726, https://openalex.org/W2025202389, https://openalex.org/W1989219897, https://openalex.org/W2038595680, https://openalex.org/W1566807090, https://openalex.org/W1509159262, https://openalex.org/W1574227883, https://openalex.org/W2037604092, https://openalex.org/W3185570049, https://openalex.org/W2014780751, https://openalex.org/W2414307244, https://openalex.org/W2167803193, https://openalex.org/W2076635588, https://openalex.org/W2088219392, https://openalex.org/W2065821845, https://openalex.org/W1541175614, https://openalex.org/W3021273191, https://openalex.org/W2524407492, https://openalex.org/W2168974130, https://openalex.org/W4211023727, https://openalex.org/W4226210057, https://openalex.org/W3022141464 |
| referenced_works_count | 68 |
| abstract_inverted_index.a | 37, 121, 145 |
| abstract_inverted_index.In | 68, 94, 114, 154 |
| abstract_inverted_index.by | 36, 62, 110 |
| abstract_inverted_index.de | 46 |
| abstract_inverted_index.in | 30, 80, 125, 131, 171 |
| abstract_inverted_index.is | 60, 78 |
| abstract_inverted_index.of | 6, 25, 43, 52, 73, 91, 102, 120, 129, 144, 148, 162, 165, 169, 178, 182 |
| abstract_inverted_index.or | 84 |
| abstract_inverted_index.to | 13 |
| abstract_inverted_index.we | 157 |
| abstract_inverted_index.GAT | 64 |
| abstract_inverted_index.GMP | 65 |
| abstract_inverted_index.The | 16, 45 |
| abstract_inverted_index.and | 8, 21, 135 |
| abstract_inverted_index.are | 107 |
| abstract_inverted_index.for | 49 |
| abstract_inverted_index.our | 163 |
| abstract_inverted_index.the | 4, 10, 22, 26, 41, 50, 63, 75, 92, 100, 103, 111, 117, 127, 132, 142, 159, 166, 174, 179 |
| abstract_inverted_index.two | 17, 31, 104 |
| abstract_inverted_index.was | 152 |
| abstract_inverted_index.GMPS | 122, 151 |
| abstract_inverted_index.also | 108 |
| abstract_inverted_index.from | 56 |
| abstract_inverted_index.most | 69 |
| abstract_inverted_index.novo | 47 |
| abstract_inverted_index.only | 140 |
| abstract_inverted_index.that | 39, 98 |
| abstract_inverted_index.this | 155, 183 |
| abstract_inverted_index.upon | 85 |
| abstract_inverted_index.(GMP) | 55 |
| abstract_inverted_index.(XMP) | 59 |
| abstract_inverted_index.1996, | 126 |
| abstract_inverted_index.GATs, | 74 |
| abstract_inverted_index.GMPS, | 172 |
| abstract_inverted_index.after | 141 |
| abstract_inverted_index.basis | 168 |
| abstract_inverted_index.being | 123 |
| abstract_inverted_index.first | 118, 175 |
| abstract_inverted_index.state | 83 |
| abstract_inverted_index.their | 81 |
| abstract_inverted_index.(GATs) | 2 |
| abstract_inverted_index.became | 138 |
| abstract_inverted_index.domain | 134 |
| abstract_inverted_index.enable | 99 |
| abstract_inverted_index.happen | 29 |
| abstract_inverted_index.ligand | 86 |
| abstract_inverted_index.mutant | 147 |
| abstract_inverted_index.native | 82 |
| abstract_inverted_index.status | 161 |
| abstract_inverted_index.(GMPS). | 67 |
| abstract_inverted_index.ammonia | 12, 76 |
| abstract_inverted_index.changes | 97 |
| abstract_inverted_index.channel | 38, 77 |
| abstract_inverted_index.crystal | 71 |
| abstract_inverted_index.current | 160 |
| abstract_inverted_index.despite | 116 |
| abstract_inverted_index.details | 90 |
| abstract_inverted_index.diverse | 14 |
| abstract_inverted_index.enabled | 61 |
| abstract_inverted_index.enzyme. | 185 |
| abstract_inverted_index.evident | 79 |
| abstract_inverted_index.pathway | 48 |
| abstract_inverted_index.pockets | 34 |
| abstract_inverted_index.present | 158 |
| abstract_inverted_index.review, | 156 |
| abstract_inverted_index.acceptor | 27, 133 |
| abstract_inverted_index.ammonia. | 44 |
| abstract_inverted_index.becoming | 173 |
| abstract_inverted_index.binding, | 87 |
| abstract_inverted_index.catalyze | 3 |
| abstract_inverted_index.conduit. | 93 |
| abstract_inverted_index.distinct | 32 |
| abstract_inverted_index.function | 181 |
| abstract_inverted_index.informed | 109 |
| abstract_inverted_index.movement | 42 |
| abstract_inverted_index.possible | 139 |
| abstract_inverted_index.transfer | 9 |
| abstract_inverted_index.Glutamine | 0 |
| abstract_inverted_index.addition, | 95 |
| abstract_inverted_index.amination | 24 |
| abstract_inverted_index.available | 70, 112 |
| abstract_inverted_index.catalysis | 130, 170 |
| abstract_inverted_index.catalytic | 18, 33, 105 |
| abstract_inverted_index.connected | 35 |
| abstract_inverted_index.contrast, | 115 |
| abstract_inverted_index.crosstalk | 137 |
| abstract_inverted_index.generated | 11 |
| abstract_inverted_index.glutamine | 7 |
| abstract_inverted_index.guanosine | 53 |
| abstract_inverted_index.molecular | 89, 167 |
| abstract_inverted_index.providing | 88 |
| abstract_inverted_index.published | 124 |
| abstract_inverted_index.structure | 119, 143 |
| abstract_inverted_index.synthesis | 51 |
| abstract_inverted_index.Plasmodium | 149 |
| abstract_inverted_index.assessment | 177 |
| abstract_inverted_index.falciparum | 150 |
| abstract_inverted_index.hydrolysis | 5 |
| abstract_inverted_index.intriguing | 184 |
| abstract_inverted_index.structures | 72 |
| abstract_inverted_index.subsequent | 23 |
| abstract_inverted_index.substrate, | 28 |
| abstract_inverted_index.synthetase | 66 |
| abstract_inverted_index.xanthosine | 57 |
| abstract_inverted_index.activities, | 19 |
| abstract_inverted_index.biochemical | 180 |
| abstract_inverted_index.chemistries | 106 |
| abstract_inverted_index.determined. | 153 |
| abstract_inverted_index.facilitates | 40 |
| abstract_inverted_index.structures. | 113 |
| abstract_inverted_index.coordination | 101 |
| abstract_inverted_index.inter-domain | 136 |
| abstract_inverted_index.metabolites. | 15 |
| abstract_inverted_index.comprehensive | 176 |
| abstract_inverted_index.monophosphate | 54, 58 |
| abstract_inverted_index.understanding | 128, 164 |
| abstract_inverted_index.conformational | 96 |
| abstract_inverted_index.glutaminolysis | 20 |
| abstract_inverted_index.glutamine-bound | 146 |
| abstract_inverted_index.amidotransferases | 1 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5024273182, https://openalex.org/A5008336818 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I100532134, https://openalex.org/I1294671590, https://openalex.org/I147481903 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/6 |
| sustainable_development_goals[0].score | 0.6200000047683716 |
| sustainable_development_goals[0].display_name | Clean water and sanitation |
| citation_normalized_percentile.value | 0.87000503 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |