GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway Article Swipe
Guoqiang Fan
,
Yanfei Li
,
Yibo Zong
,
Xiaoyi Suo
,
Yimin Jia
,
Mingming Gao
,
Xiaojing Yang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1038/s41419-023-05741-z
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1038/s41419-023-05741-z
In the process of inflammatory activation, macrophages exhibit lipid metabolism disorders and accumulate lipid droplets. Kupffer cells (KCs) are the resident hepatic macrophage with critical defense functions in the pathogenesis of several types of liver disease. How dysregulated lipid metabolism contributes to perturbed KCs functions remains elusive. Here we report that glycerol-3-phosphate acyltransferase 3 (GPAT3) plays a key role in KCs inflammation response. Our findings indicate that lipopolysaccharide (LPS)-mediated inflammatory activation markedly increased lipid droplets (LDs) accumulation in KCs. This increase could be attributed to significantly up-regulated GPAT3. The loss of GPAT3 function obviously reduced KCs inflammation reaction both in vivo and in vitro, and was accompanied by improved mitochondrial function and decreased production of lysophosphatidic acid (LPA), in turn inhibiting extracellular regulated protein kinases (ERK) signaling pathway. Overall, this study highlights the role of GPAT3 in inflammatory activation of KCs and could thus be a potential therapeutic target for the treatment of inflammation-related liver disease.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41419-023-05741-z
- https://www.nature.com/articles/s41419-023-05741-z.pdf
- OA Status
- gold
- Cited By
- 15
- References
- 55
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4360863474
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4360863474Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41419-023-05741-zDigital Object Identifier
- Title
-
GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathwayWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-03-24Full publication date if available
- Authors
-
Guoqiang Fan, Yanfei Li, Yibo Zong, Xiaoyi Suo, Yimin Jia, Mingming Gao, Xiaojing YangList of authors in order
- Landing page
-
https://doi.org/10.1038/s41419-023-05741-zPublisher landing page
- PDF URL
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https://www.nature.com/articles/s41419-023-05741-z.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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-
https://www.nature.com/articles/s41419-023-05741-z.pdfDirect OA link when available
- Concepts
-
Inflammation, Lysophosphatidic acid, Cell biology, Lipid metabolism, Lipid droplet, Lipid signaling, Signal transduction, Macrophage, MAPK/ERK pathway, Lipopolysaccharide, Kinase, Acyltransferase, Pathogenesis, Chemistry, Biology, Biochemistry, In vitro, Immunology, Enzyme, ReceptorTop concepts (fields/topics) attached by OpenAlex
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-
15Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 8, 2024: 5, 2023: 2Per-year citation counts (last 5 years)
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55Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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