GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA Article Swipe
Alistair Rice
,
Ernesto Cortés
,
Dariusz Lachowski
,
Philipp Oertle
,
Carlos Matellan
,
Stephen D. Thorpe
,
Ritobrata Ghose
,
Haiyun Wang
,
David A. Lee
,
Marija Plodinec
,
Armando E. del Río Hernández
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/cancers12020289
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/cancers12020289
The invasive properties of cancer cells are intimately linked to their mechanical phenotype, which can be regulated by intracellular biochemical signalling. Cell contractility, induced by mechanotransduction of a stiff fibrotic matrix, and the epithelial–mesenchymal transition (EMT) promote invasion. Metastasis involves cells pushing through the basement membrane into the stroma—both of which are altered in composition with cancer progression. Agonists of the G protein-coupled oestrogen receptor (GPER), such as tamoxifen, have been largely used in the clinic, and interest in GPER, which is abundantly expressed in tissues, has greatly increased despite a lack of understanding regarding the mechanisms which promote its multiple effects. Here, we show that specific activation of GPER inhibits EMT, mechanotransduction and cell contractility in cancer cells via the GTPase Ras homolog family member A (RhoA). We further show that GPER activation inhibits invasion through an in vitro basement membrane mimic, similar in structure to the pancreatic basement membrane that we reveal as an asymmetric bilayer, which differs in composition between healthy and cancer patients.
Related Topics
Concepts
RHOA
GPER
Mechanotransduction
Cell biology
Basement membrane
Cancer cell
Chemistry
Desmoplasia
Invadopodia
Cancer research
Metastasis
Biology
Cancer
Signal transduction
Estrogen receptor
Pancreatic cancer
Breast cancer
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers12020289
- https://www.mdpi.com/2072-6694/12/2/289/pdf?version=1582945741
- OA Status
- gold
- Cited By
- 29
- References
- 78
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3002692285
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3002692285Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cancers12020289Digital Object Identifier
- Title
-
GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoAWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-25Full publication date if available
- Authors
-
Alistair Rice, Ernesto Cortés, Dariusz Lachowski, Philipp Oertle, Carlos Matellan, Stephen D. Thorpe, Ritobrata Ghose, Haiyun Wang, David A. Lee, Marija Plodinec, Armando E. del Río HernándezList of authors in order
- Landing page
-
https://doi.org/10.3390/cancers12020289Publisher landing page
- PDF URL
-
https://www.mdpi.com/2072-6694/12/2/289/pdf?version=1582945741Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2072-6694/12/2/289/pdf?version=1582945741Direct OA link when available
- Concepts
-
RHOA, GPER, Mechanotransduction, Cell biology, Basement membrane, Cancer cell, Chemistry, Desmoplasia, Invadopodia, Cancer research, Metastasis, Biology, Cancer, Signal transduction, Estrogen receptor, Pancreatic cancer, Breast cancer, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
29Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 8, 2024: 5, 2023: 4, 2022: 6, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
78Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.such | 66 |
| abstract_inverted_index.that | 105, 131, 151 |
| abstract_inverted_index.used | 72 |
| abstract_inverted_index.with | 55 |
| abstract_inverted_index.(EMT) | 35 |
| abstract_inverted_index.GPER, | 79 |
| abstract_inverted_index.Here, | 102 |
| abstract_inverted_index.cells | 5, 40, 118 |
| abstract_inverted_index.stiff | 28 |
| abstract_inverted_index.their | 10 |
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| abstract_inverted_index.which | 13, 50, 80, 97, 158 |
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| abstract_inverted_index.cancer | 4, 56, 117, 165 |
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| abstract_inverted_index.linked | 8 |
| abstract_inverted_index.member | 125 |
| abstract_inverted_index.mimic, | 142 |
| abstract_inverted_index.reveal | 153 |
| abstract_inverted_index.(GPER), | 65 |
| abstract_inverted_index.(RhoA). | 127 |
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| abstract_inverted_index.clinic, | 75 |
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| abstract_inverted_index.bilayer, | 157 |
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| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5047705039, https://openalex.org/A5090579348 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I1850255, https://openalex.org/I47508984 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6399999856948853 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.87514061 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |