Grade 4 Mucositis Secondary to Methotrexate Use in a Pediatric Patient With Stage IV Burkitt Lymphoma: A Case Report Article Swipe
Fabian A. Mendoza
,
Circe Ancona Castro
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7759/cureus.90944
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7759/cureus.90944
Non-Hodgkin lymphoma (NHL) is a monoclonal neoplastic proliferation of lymphoid cells that can arise in different components of the immune system. Methotrexate (MTX), an antifolate agent, is widely used in the treatment of malignancies and autoimmune diseases. One of its most significant toxicities is gastrointestinal mucositis, a dose-dependent mucosal injury that can involve the entire alimentary tract and manifest as painful oral and intestinal ulcerations. We present the case of a pediatric patient with stage IV Burkitt lymphoma who developed severe mucocutaneous toxicity after MTX administration. This report also reviews risk factors associated with heightened toxicity and highlights strategies for prevention and management of MTX-induced oral mucositis, with particular emphasis on the clinical importance of delayed drug clearance, which increases the risk of multisystem toxicity and mortality.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7759/cureus.90944
- https://www.cureus.com/articles/403209-grade-4-mucositis-secondary-to-methotrexate-use-in-a-pediatric-patient-with-stage-iv-burkitt-lymphoma-a-case-report.pdf
- OA Status
- diamond
- Cited By
- 1
- References
- 17
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413502333
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413502333Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7759/cureus.90944Digital Object Identifier
- Title
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Grade 4 Mucositis Secondary to Methotrexate Use in a Pediatric Patient With Stage IV Burkitt Lymphoma: A Case ReportWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-08-25Full publication date if available
- Authors
-
Fabian A. Mendoza, Circe Ancona CastroList of authors in order
- Landing page
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https://doi.org/10.7759/cureus.90944Publisher landing page
- PDF URL
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https://www.cureus.com/articles/403209-grade-4-mucositis-secondary-to-methotrexate-use-in-a-pediatric-patient-with-stage-iv-burkitt-lymphoma-a-case-report.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
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-
https://www.cureus.com/articles/403209-grade-4-mucositis-secondary-to-methotrexate-use-in-a-pediatric-patient-with-stage-iv-burkitt-lymphoma-a-case-report.pdfDirect OA link when available
- Concepts
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Medicine, Mucositis, Methotrexate, Lymphoma, Burkitt's lymphoma, Stage (stratigraphy), Pediatric oncology, Pediatrics, Internal medicine, Dermatology, Chemotherapy, Cancer, Biology, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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17Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.that | 11, 50 |
| abstract_inverted_index.used | 28 |
| abstract_inverted_index.with | 73, 93, 107 |
| abstract_inverted_index.(NHL) | 2 |
| abstract_inverted_index.after | 83 |
| abstract_inverted_index.arise | 13 |
| abstract_inverted_index.cells | 10 |
| abstract_inverted_index.stage | 74 |
| abstract_inverted_index.tract | 56 |
| abstract_inverted_index.which | 118 |
| abstract_inverted_index.(MTX), | 22 |
| abstract_inverted_index.agent, | 25 |
| abstract_inverted_index.entire | 54 |
| abstract_inverted_index.immune | 19 |
| abstract_inverted_index.injury | 49 |
| abstract_inverted_index.report | 87 |
| abstract_inverted_index.severe | 80 |
| abstract_inverted_index.widely | 27 |
| abstract_inverted_index.Burkitt | 76 |
| abstract_inverted_index.delayed | 115 |
| abstract_inverted_index.factors | 91 |
| abstract_inverted_index.involve | 52 |
| abstract_inverted_index.mucosal | 48 |
| abstract_inverted_index.painful | 60 |
| abstract_inverted_index.patient | 72 |
| abstract_inverted_index.present | 66 |
| abstract_inverted_index.reviews | 89 |
| abstract_inverted_index.system. | 20 |
| abstract_inverted_index.clinical | 112 |
| abstract_inverted_index.emphasis | 109 |
| abstract_inverted_index.lymphoid | 9 |
| abstract_inverted_index.lymphoma | 1, 77 |
| abstract_inverted_index.manifest | 58 |
| abstract_inverted_index.toxicity | 82, 95, 124 |
| abstract_inverted_index.developed | 79 |
| abstract_inverted_index.different | 15 |
| abstract_inverted_index.diseases. | 36 |
| abstract_inverted_index.increases | 119 |
| abstract_inverted_index.pediatric | 71 |
| abstract_inverted_index.treatment | 31 |
| abstract_inverted_index.alimentary | 55 |
| abstract_inverted_index.antifolate | 24 |
| abstract_inverted_index.associated | 92 |
| abstract_inverted_index.autoimmune | 35 |
| abstract_inverted_index.clearance, | 117 |
| abstract_inverted_index.components | 16 |
| abstract_inverted_index.heightened | 94 |
| abstract_inverted_index.highlights | 97 |
| abstract_inverted_index.importance | 113 |
| abstract_inverted_index.intestinal | 63 |
| abstract_inverted_index.management | 102 |
| abstract_inverted_index.monoclonal | 5 |
| abstract_inverted_index.mortality. | 126 |
| abstract_inverted_index.mucositis, | 45, 106 |
| abstract_inverted_index.neoplastic | 6 |
| abstract_inverted_index.particular | 108 |
| abstract_inverted_index.prevention | 100 |
| abstract_inverted_index.strategies | 98 |
| abstract_inverted_index.toxicities | 42 |
| abstract_inverted_index.MTX-induced | 104 |
| abstract_inverted_index.Non-Hodgkin | 0 |
| abstract_inverted_index.multisystem | 123 |
| abstract_inverted_index.significant | 41 |
| abstract_inverted_index.Methotrexate | 21 |
| abstract_inverted_index.malignancies | 33 |
| abstract_inverted_index.ulcerations. | 64 |
| abstract_inverted_index.mucocutaneous | 81 |
| abstract_inverted_index.proliferation | 7 |
| abstract_inverted_index.dose-dependent | 47 |
| abstract_inverted_index.administration. | 85 |
| abstract_inverted_index.gastrointestinal | 44 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 2 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.5299999713897705 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.91266042 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |