Granulocyte Colony-Stimulating Factor Utilization and Prescribing Patterns in Cancer Patients: A Single Institution Experience of a Saudi Cancer Center Article Swipe
Mohammad J Alyamani
,
Haya AlSalloum
,
Ghada Elgohary
,
Khalid Alsaleh
,
Ahmed Abd El Warith
,
Nashwa Abd El-Aziz
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.7759/cureus.27017
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.7759/cureus.27017
Background Febrile neutropenia (FN), owing to its negative association with immune function and infectious complications, acts as a treatment-limiting factor in myelotoxic cancer chemotherapy. This study aimed to analyze the incidence of FN, utilization of granulocyte colony-stimulating factor (G-CSF) in patients who experienced FN, and its association with age and comorbidities. Methodology This retrospective study was conducted in a major tertiary hospital in Riyadh, Kingdom of Saudi Arabia. Inclusion criteria entailed all neutropenic adults aged >18 years with a proven cancer diagnosis, including solid and hematological malignancies. Patients who were treated with chemotherapy and G-CSF were included in the study. Data regarding FN, administration of G-CSF, and patient and physician-related factors were collected. Results We collected data on 53 cancer patients with a mean age of 41.9 ± 17.1 years (range = 16-75). FN was present in 16 (30.2%) patients and absent in 37 (69.8%) patients. The mean neutrophil count post-filgrastim did not significantly differ from pre-chemotherapy neutrophil count (Student's t-test, p = 0.067), while there was a significant difference from post-chemotherapy neutrophil count (Student's t-test, p = 0.044). In our cohort, 24 (45.3%) patients achieved remission, 12 (22.6%) died, and 17 (32.1%) were not cured. We did not find any significant association between gender, specialty, comorbidities, and age with FN. Conclusions G-CSF administration significantly decreases the incidence of FN post-chemotherapy in cancer patients.
Related Topics
Concepts
Medicine
Internal medicine
Neutropenia
Absolute neutrophil count
Chemotherapy
Cancer
Incidence (geometry)
Filgrastim
Febrile neutropenia
Granulocyte colony-stimulating factor
Retrospective cohort study
Single Center
Gastroenterology
Surgery
Physics
Optics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7759/cureus.27017
- https://www.cureus.com/articles/93571-granulocyte-colony-stimulating-factor-utilization-and-prescribing-patterns-in-cancer-patients-a-single-institution-experience-of-a-saudi-cancer-center.pdf
- OA Status
- diamond
- Cited By
- 1
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4286220787
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4286220787Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.7759/cureus.27017Digital Object Identifier
- Title
-
Granulocyte Colony-Stimulating Factor Utilization and Prescribing Patterns in Cancer Patients: A Single Institution Experience of a Saudi Cancer CenterWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-07-19Full publication date if available
- Authors
-
Mohammad J Alyamani, Haya AlSalloum, Ghada Elgohary, Khalid Alsaleh, Ahmed Abd El Warith, Nashwa Abd El-AzizList of authors in order
- Landing page
-
https://doi.org/10.7759/cureus.27017Publisher landing page
- PDF URL
-
https://www.cureus.com/articles/93571-granulocyte-colony-stimulating-factor-utilization-and-prescribing-patterns-in-cancer-patients-a-single-institution-experience-of-a-saudi-cancer-center.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.cureus.com/articles/93571-granulocyte-colony-stimulating-factor-utilization-and-prescribing-patterns-in-cancer-patients-a-single-institution-experience-of-a-saudi-cancer-center.pdfDirect OA link when available
- Concepts
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Medicine, Internal medicine, Neutropenia, Absolute neutrophil count, Chemotherapy, Cancer, Incidence (geometry), Filgrastim, Febrile neutropenia, Granulocyte colony-stimulating factor, Retrospective cohort study, Single Center, Gastroenterology, Surgery, Physics, OpticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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31Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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