Graves Olgularında Kardiyovasküler Hastalık Risk Değerlendirmesi: Trombosit İndekslerinin Rolü Article Swipe

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Hakim Çelık , Seyhan Taşkın , Adnan Kirmit , Mehmet Ali Eren ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.5798/dicletip.800294

Amaç: Gelişmiş ülkelerde en sık görülen hipertiroidi nedeni olarak belirtilen Graves hastalığı, tirotoksikoz, diffüz guatr ve oftalmopati ile karakterize otoimmün bir hastalıktır. Tiroid hormonunun, kardiyovasküler hemodinamiği değiştirebilecek etkilere sahip olması, hipertroidili hastaların kardiyovasküler komplikasyonlara yakalanma riskini arttırmaktadır. Tam kan sayımında rutin olarak rapor edilen; ortalama trombosit hacmi başta olmak üzere, trombosit indeksleri kardiyovasküler hastalıkların gelişimi ve takibinde önemli biyobelirteçler olarak kabul edilmektedir. Bu nedenle çalışmamızda Graves hastalığının kardiyovasküler hastalıklar ile ilişkisini değerlendirebilmek amacıyla trombosit indekslerinin rolü araştırıldı. Yöntemler: Çalışmaya 33 Graves hipertiroidili hasta ile cinsiyet, yaş ve vücut kitle indeksi benzer 37 sağlıklı kontrol dahil edildi. Çalışmada rutin olarak ölçülmüş olan trombosit indeksleri ve tiroid fonksiyon parametreleri incelendi. Bulgular: Graves hastaları ile kontrol grupları arasında trombosit sayısı ve trombosit yüzdesi bakımından anlamlı herhangi bir fark bulunmazken (sırasıyla; p= 0,202; p= 0,289), ortalama trombosit hacmi ve trombosit dağılım genişliği Graves hastalarında kontrol grubuna göre anlamlı ölçüde yüksek bulundu (sırasıyla; p< 0,001; p= 0,015). Ayrıca Graves hastalarında ortalama trombosit hacmi ve trombosit dağılım genişliği ile serbest triiyodotironin arasında anlamlı pozitif ilişki saptanmıştır (sırasıyla; r= 0,505; p= 0,003 ve r= 0,366; p= 0,036). Yapılan alıcı işletim karakteristiği (ROC) analizine göre Graves hastalarında, ortalama trombosit hacmi ve trombosit dağılım genişliği düzeylerinin kardiyovasküler hastalıkların risk değerlendirilmesi için kabul edilebilir bir prediktif değere sahip olduğu gösterilmiştir. Sonuç: Sonuç olarak, Graves hastalarında kardiyovasküler hastalıkları öngörebilecek önemli biyobelirteçler olduğu düşünülen ortalama trombosit hacmi ve trombosit dağılım genişliği yüksek bulunmuştur. Bu durum Graves hastalarının kardiyovasküler hastalıklara yakalanma riskinin yüksek olabileceğini düşündürmektedir.

Related Topics

Medicine

Gynaecology

Concepts

Medicine Gynecology

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Type: article
Language: tr
Landing Page: https://doi.org/10.5798/dicletip.800294
PDF: https://dergipark.org.tr/tr/download/article-file/1310502
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DOI: https://doi.org/10.5798/dicletip.800294

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Title: Graves Olgularında Kardiyovasküler Hastalık Risk Değerlendirmesi: Trombosit İndekslerinin Rolü

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Language: tr

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Publication year: 2020

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Authors: Hakim Çelık, Seyhan Taşkın, Adnan Kirmit, Mehmet Ali Eren

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Landing page: https://doi.org/10.5798/dicletip.800294

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abstract_inverted_index.ilişkisini	70
abstract_inverted_index.karakterize	18
abstract_inverted_index.oftalmopati	16
abstract_inverted_index.sayımında	39
abstract_inverted_index.sağlıklı	92
abstract_inverted_index.bakımından	120
abstract_inverted_index.hastalıklar	68
abstract_inverted_index.hipertiroidi	6
abstract_inverted_index.Çalışmada	96
abstract_inverted_index.Çalışmaya	78
abstract_inverted_index.(sırasıyla;	126, 147, 170
abstract_inverted_index.bulunmuştur.	230
abstract_inverted_index.düzeylerinin	196
abstract_inverted_index.düşünülen	221
abstract_inverted_index.edilmektedir.	61
abstract_inverted_index.hastalarında	139, 154, 214
abstract_inverted_index.hastalıklara	236
abstract_inverted_index.hastalığı,	11
abstract_inverted_index.hemodinamiği	25
abstract_inverted_index.hipertroidili	30
abstract_inverted_index.indekslerinin	74
abstract_inverted_index.parametreleri	106
abstract_inverted_index.tirotoksikoz,	12
abstract_inverted_index.ölçülmüş	99
abstract_inverted_index.hastalarında,	188
abstract_inverted_index.hastalarının	234
abstract_inverted_index.hastalıkları	216
abstract_inverted_index.hastalıktır.	21
abstract_inverted_index.hipertiroidili	81
abstract_inverted_index.olabileceğini	240
abstract_inverted_index.hastalıkların	53, 198
abstract_inverted_index.karakteristiği	183
abstract_inverted_index.saptanmıştır	169
abstract_inverted_index.triiyodotironin	164
abstract_inverted_index.öngörebilecek	217
abstract_inverted_index.biyobelirteçler	58, 219
abstract_inverted_index.hastalığının	66
abstract_inverted_index.incelendi.	107
abstract_inverted_index.kardiyovasküler	24, 32, 52, 67, 197, 215, 235
abstract_inverted_index.komplikasyonlara	33
abstract_inverted_index.çalışmamızda	64
abstract_inverted_index.arttırmaktadır.	36
abstract_inverted_index.değerlendirilmesi	200
abstract_inverted_index.değiştirebilecek	26
abstract_inverted_index.değerlendirebilmek	71
abstract_inverted_index.düşündürmektedir.	241
abstract_inverted_index.araştırıldı.	76
abstract_inverted_index.gösterilmiştir.	209
cited_by_percentile_year.max	93
cited_by_percentile_year.min	89
countries_distinct_count	1
institutions_distinct_count	4
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.6700000166893005
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.53262125
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False