Gravida and Birth Outcomes Prior to and after Diagnosis of Early Age–Onset Colorectal Cancer among Female Patients: Population-Based Epidemiologic Studies Article Swipe
Niki Oveisi
,
Eric C. Sayre
,
Sharlene Gill
,
Vicki Cheng
,
Vienna Cheng
,
Lori A. Brotto
,
Stuart Peacock
,
Helen McTaggart‐Cowan
,
Gillian E. Hanley
,
Amirrtha Srikanthan
,
Mary A. De Vera
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1158/1055-9965.epi-25-0442
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1158/1055-9965.epi-25-0442
Background: Early age–onset colorectal cancer (EAO-CRC) strikes during the reproductive years, yet pregnancies before and after diagnosis have not been thoroughly studied. Our objective was to comprehensively examine: (i) the relationship between gravida and EAO-CRC and (ii) the relationship between EAO-CRC and births after cancer diagnosis. Methods: We conducted a case–control and a cohort study using administrative health data from British Columbia, Canada, of females diagnosed with EAO-CRC from 2005 to 2017 and age- and sex-matched cancer-free controls. Multivariable logistic regression models were used to evaluate: (i) the association between gravida assessed over the 5-year prodrome period before cancer diagnosis and EAO-CRC and (ii) the association between EAO-CRC and births assessed over a 5-year period following cancer diagnosis. Results: The study sample consisted of 865 females (age at EAO-CRC diagnosis 42.5 ± 6.1 years) with EAO-CRC and 8,291 controls (42.4 ± 6.3 years). Females with a gravida of ≥2 in the 5-year prodrome period had 1.82 times the odds of EAO-CRC compared with those with gravida of 0 (OR, 1.82; 95% confidence interval, 1.19–2.78). After cancer diagnosis, females with EAO-CRC had significantly lower odds of giving birth within five years (OR, 0.23; 95% confidence interval, 0.15–0.37). Older age, lower income, rural residence, and greater healthcare utilization were associated with lower odds of post-diagnosis births. Conclusions: Our study highlights the complex relationship between reproductive health and EAO-CRC. Impact: Findings indicate a need for comprehensive psychosocial support addressing family planning for female patients with EAO-CRC.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1158/1055-9965.epi-25-0442
- https://aacrjournals.org/cebp/article-pdf/doi/10.1158/1055-9965.EPI-25-0442/3622158/epi-25-0442.pdf
- OA Status
- hybrid
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411413483
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4411413483Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1158/1055-9965.epi-25-0442Digital Object Identifier
- Title
-
Gravida and Birth Outcomes Prior to and after Diagnosis of Early Age–Onset Colorectal Cancer among Female Patients: Population-Based Epidemiologic StudiesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-06-18Full publication date if available
- Authors
-
Niki Oveisi, Eric C. Sayre, Sharlene Gill, Vicki Cheng, Vienna Cheng, Lori A. Brotto, Stuart Peacock, Helen McTaggart‐Cowan, Gillian E. Hanley, Amirrtha Srikanthan, Mary A. De VeraList of authors in order
- Landing page
-
https://doi.org/10.1158/1055-9965.epi-25-0442Publisher landing page
- PDF URL
-
https://aacrjournals.org/cebp/article-pdf/doi/10.1158/1055-9965.EPI-25-0442/3622158/epi-25-0442.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://aacrjournals.org/cebp/article-pdf/doi/10.1158/1055-9965.EPI-25-0442/3622158/epi-25-0442.pdfDirect OA link when available
- Concepts
-
Medicine, Odds ratio, Colorectal cancer, Cancer, Confidence interval, Logistic regression, Demography, Population, Cohort, Odds, Gynecology, Obstetrics, Internal medicine, Environmental health, SociologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
24Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4411413483 |
|---|---|
| doi | https://doi.org/10.1158/1055-9965.epi-25-0442 |
| ids.doi | https://doi.org/10.1158/1055-9965.epi-25-0442 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40531200 |
| ids.openalex | https://openalex.org/W4411413483 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D005260 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Female |
| mesh[2].qualifier_ui | Q000453 |
| mesh[2].descriptor_ui | D015179 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | epidemiology |
| mesh[2].descriptor_name | Colorectal Neoplasms |
| mesh[3].qualifier_ui | Q000175 |
| mesh[3].descriptor_ui | D015179 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | diagnosis |
| mesh[3].descriptor_name | Colorectal Neoplasms |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D000328 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Adult |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D011247 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Pregnancy |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D016022 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Case-Control Studies |
| mesh[7].qualifier_ui | Q000453 |
| mesh[7].descriptor_ui | D001955 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | epidemiology |
| mesh[7].descriptor_name | British Columbia |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D017668 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Age of Onset |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D008875 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Middle Aged |
| mesh[10].qualifier_ui | Q000453 |
| mesh[10].descriptor_ui | D011256 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | epidemiology |
| mesh[10].descriptor_name | Pregnancy Outcome |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D006801 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Humans |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D005260 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Female |
| mesh[13].qualifier_ui | Q000453 |
| mesh[13].descriptor_ui | D015179 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | epidemiology |
| mesh[13].descriptor_name | Colorectal Neoplasms |
| mesh[14].qualifier_ui | Q000175 |
| mesh[14].descriptor_ui | D015179 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | diagnosis |
| mesh[14].descriptor_name | Colorectal Neoplasms |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D000328 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Adult |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D011247 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Pregnancy |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D016022 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Case-Control Studies |
| mesh[18].qualifier_ui | Q000453 |
| mesh[18].descriptor_ui | D001955 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | epidemiology |
| mesh[18].descriptor_name | British Columbia |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D017668 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Age of Onset |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D008875 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Middle Aged |
| mesh[21].qualifier_ui | Q000453 |
| mesh[21].descriptor_ui | D011256 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | epidemiology |
| mesh[21].descriptor_name | Pregnancy Outcome |
| type | article |
| title | Gravida and Birth Outcomes Prior to and after Diagnosis of Early Age–Onset Colorectal Cancer among Female Patients: Population-Based Epidemiologic Studies |
| biblio.issue | 9 |
| biblio.volume | 34 |
| biblio.last_page | 1584 |
| biblio.first_page | 1577 |
| topics[0].id | https://openalex.org/T12103 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9958000183105469 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2730 |
| topics[0].subfield.display_name | Oncology |
| topics[0].display_name | Cancer Risks and Factors |
| topics[1].id | https://openalex.org/T11629 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9851999878883362 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2735 |
| topics[1].subfield.display_name | Pediatrics, Perinatology and Child Health |
| topics[1].display_name | Birth, Development, and Health |
| topics[2].id | https://openalex.org/T13574 |
| topics[2].field.id | https://openalex.org/fields/33 |
| topics[2].field.display_name | Social Sciences |
| topics[2].score | 0.9718999862670898 |
| topics[2].domain.id | https://openalex.org/domains/2 |
| topics[2].domain.display_name | Social Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/3312 |
| topics[2].subfield.display_name | Sociology and Political Science |
| topics[2].display_name | Family Support in Illness |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.8835086226463318 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C156957248 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7280137538909912 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1862216 |
| concepts[1].display_name | Odds ratio |
| concepts[2].id | https://openalex.org/C526805850 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6618711948394775 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q188874 |
| concepts[2].display_name | Colorectal cancer |
| concepts[3].id | https://openalex.org/C121608353 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5524682402610779 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[3].display_name | Cancer |
| concepts[4].id | https://openalex.org/C44249647 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5493918061256409 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q208498 |
| concepts[4].display_name | Confidence interval |
| concepts[5].id | https://openalex.org/C151956035 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5433850884437561 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q1132755 |
| concepts[5].display_name | Logistic regression |
| concepts[6].id | https://openalex.org/C149923435 |
| concepts[6].level | 1 |
| concepts[6].score | 0.45659101009368896 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q37732 |
| concepts[6].display_name | Demography |
| concepts[7].id | https://openalex.org/C2908647359 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4441301226615906 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q2625603 |
| concepts[7].display_name | Population |
| concepts[8].id | https://openalex.org/C72563966 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4375399649143219 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1303415 |
| concepts[8].display_name | Cohort |
| concepts[9].id | https://openalex.org/C143095724 |
| concepts[9].level | 3 |
| concepts[9].score | 0.4305815100669861 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q515895 |
| concepts[9].display_name | Odds |
| concepts[10].id | https://openalex.org/C29456083 |
| concepts[10].level | 1 |
| concepts[10].score | 0.41520100831985474 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q1221899 |
| concepts[10].display_name | Gynecology |
| concepts[11].id | https://openalex.org/C131872663 |
| concepts[11].level | 1 |
| concepts[11].score | 0.4018794298171997 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q5284418 |
| concepts[11].display_name | Obstetrics |
| concepts[12].id | https://openalex.org/C126322002 |
| concepts[12].level | 1 |
| concepts[12].score | 0.32301026582717896 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[12].display_name | Internal medicine |
| concepts[13].id | https://openalex.org/C99454951 |
| concepts[13].level | 1 |
| concepts[13].score | 0.059141457080841064 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q932068 |
| concepts[13].display_name | Environmental health |
| concepts[14].id | https://openalex.org/C144024400 |
| concepts[14].level | 0 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q21201 |
| concepts[14].display_name | Sociology |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.8835086226463318 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/odds-ratio |
| keywords[1].score | 0.7280137538909912 |
| keywords[1].display_name | Odds ratio |
| keywords[2].id | https://openalex.org/keywords/colorectal-cancer |
| keywords[2].score | 0.6618711948394775 |
| keywords[2].display_name | Colorectal cancer |
| keywords[3].id | https://openalex.org/keywords/cancer |
| keywords[3].score | 0.5524682402610779 |
| keywords[3].display_name | Cancer |
| keywords[4].id | https://openalex.org/keywords/confidence-interval |
| keywords[4].score | 0.5493918061256409 |
| keywords[4].display_name | Confidence interval |
| keywords[5].id | https://openalex.org/keywords/logistic-regression |
| keywords[5].score | 0.5433850884437561 |
| keywords[5].display_name | Logistic regression |
| keywords[6].id | https://openalex.org/keywords/demography |
| keywords[6].score | 0.45659101009368896 |
| keywords[6].display_name | Demography |
| keywords[7].id | https://openalex.org/keywords/population |
| keywords[7].score | 0.4441301226615906 |
| keywords[7].display_name | Population |
| keywords[8].id | https://openalex.org/keywords/cohort |
| keywords[8].score | 0.4375399649143219 |
| keywords[8].display_name | Cohort |
| keywords[9].id | https://openalex.org/keywords/odds |
| keywords[9].score | 0.4305815100669861 |
| keywords[9].display_name | Odds |
| keywords[10].id | https://openalex.org/keywords/gynecology |
| keywords[10].score | 0.41520100831985474 |
| keywords[10].display_name | Gynecology |
| keywords[11].id | https://openalex.org/keywords/obstetrics |
| keywords[11].score | 0.4018794298171997 |
| keywords[11].display_name | Obstetrics |
| keywords[12].id | https://openalex.org/keywords/internal-medicine |
| keywords[12].score | 0.32301026582717896 |
| keywords[12].display_name | Internal medicine |
| keywords[13].id | https://openalex.org/keywords/environmental-health |
| keywords[13].score | 0.059141457080841064 |
| keywords[13].display_name | Environmental health |
| language | en |
| locations[0].id | doi:10.1158/1055-9965.epi-25-0442 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S8391440 |
| locations[0].source.issn | 1055-9965, 1538-7755 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1055-9965 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Cancer Epidemiology Biomarkers & Prevention |
| locations[0].source.host_organization | https://openalex.org/P4310320273 |
| locations[0].source.host_organization_name | American Association for Cancer Research |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320273 |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | https://aacrjournals.org/cebp/article-pdf/doi/10.1158/1055-9965.EPI-25-0442/3622158/epi-25-0442.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cancer Epidemiology, Biomarkers & Prevention |
| locations[0].landing_page_url | https://doi.org/10.1158/1055-9965.epi-25-0442 |
| locations[1].id | pmid:40531200 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40531200 |
| locations[2].id | pmh:oai:europepmc.org:11212794 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12402779 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5091851125 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-5688-6125 |
| authorships[0].author.display_name | Niki Oveisi |
| authorships[0].countries | CA |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[0].affiliations[0].raw_affiliation_string | University of British Columbia, Vancouver, BC, Canada |
| authorships[0].institutions[0].id | https://openalex.org/I141945490 |
| authorships[0].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[0].institutions[0].country_code | CA |
| authorships[0].institutions[0].display_name | University of British Columbia |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Niki Oveisi |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | University of British Columbia, Vancouver, BC, Canada |
| authorships[1].author.id | https://openalex.org/A5042000390 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-4526-278X |
| authorships[1].author.display_name | Eric C. Sayre |
| authorships[1].countries | CA |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210100522 |
| authorships[1].affiliations[0].raw_affiliation_string | British Columbia Centre on Substance Use, Vancouver, BC, Canada |
| authorships[1].institutions[0].id | https://openalex.org/I4210100522 |
| authorships[1].institutions[0].ror | https://ror.org/017w5sv42 |
| authorships[1].institutions[0].type | nonprofit |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210100522 |
| authorships[1].institutions[0].country_code | CA |
| authorships[1].institutions[0].display_name | British Columbia Centre on Substance Use |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Eric C. Sayre |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | British Columbia Centre on Substance Use, Vancouver, BC, Canada |
| authorships[2].author.id | https://openalex.org/A5070331492 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-3306-3617 |
| authorships[2].author.display_name | Sharlene Gill |
| authorships[2].countries | CA |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1289530486 |
| authorships[2].affiliations[0].raw_affiliation_string | BC Cancer Agency, Vancouver, BC, Canada |
| authorships[2].institutions[0].id | https://openalex.org/I1289530486 |
| authorships[2].institutions[0].ror | https://ror.org/03sfybe47 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I1289530486 |
| authorships[2].institutions[0].country_code | CA |
| authorships[2].institutions[0].display_name | BC Cancer Agency |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Sharlene Gill |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | BC Cancer Agency, Vancouver, BC, Canada |
| authorships[3].author.id | https://openalex.org/A5013320206 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-5030-9135 |
| authorships[3].author.display_name | Vicki Cheng |
| authorships[3].countries | CA |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[3].affiliations[0].raw_affiliation_string | University of British Columbia, Vancouver, BC, Canada |
| authorships[3].institutions[0].id | https://openalex.org/I141945490 |
| authorships[3].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[3].institutions[0].country_code | CA |
| authorships[3].institutions[0].display_name | University of British Columbia |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Vicki Cheng |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | University of British Columbia, Vancouver, BC, Canada |
| authorships[4].author.id | https://openalex.org/A5102944360 |
| authorships[4].author.orcid | https://orcid.org/0009-0009-7053-559X |
| authorships[4].author.display_name | Vienna Cheng |
| authorships[4].countries | CA |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[4].affiliations[0].raw_affiliation_string | University of British Columbia, Vancouver, BC, Canada |
| authorships[4].institutions[0].id | https://openalex.org/I141945490 |
| authorships[4].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[4].institutions[0].country_code | CA |
| authorships[4].institutions[0].display_name | University of British Columbia |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Vienna Cheng |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | University of British Columbia, Vancouver, BC, Canada |
| authorships[5].author.id | https://openalex.org/A5033423671 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-7552-8588 |
| authorships[5].author.display_name | Lori A. Brotto |
| authorships[5].countries | CA |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[5].affiliations[0].raw_affiliation_string | University of British Columbia, Vancouver, Canada |
| authorships[5].institutions[0].id | https://openalex.org/I141945490 |
| authorships[5].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[5].institutions[0].country_code | CA |
| authorships[5].institutions[0].display_name | University of British Columbia |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Lori A. Brotto |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | University of British Columbia, Vancouver, Canada |
| authorships[6].author.id | https://openalex.org/A5076902800 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-8243-8721 |
| authorships[6].author.display_name | Stuart Peacock |
| authorships[6].countries | CA |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I1289530486 |
| authorships[6].affiliations[0].raw_affiliation_string | British Columbia Cancer Agency, Vancouver, British Columbia, Canada |
| authorships[6].institutions[0].id | https://openalex.org/I1289530486 |
| authorships[6].institutions[0].ror | https://ror.org/03sfybe47 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I1289530486 |
| authorships[6].institutions[0].country_code | CA |
| authorships[6].institutions[0].display_name | BC Cancer Agency |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Stuart Peacock |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | British Columbia Cancer Agency, Vancouver, British Columbia, Canada |
| authorships[7].author.id | https://openalex.org/A5034664713 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-5451-0845 |
| authorships[7].author.display_name | Helen McTaggart‐Cowan |
| authorships[7].countries | CA |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I1289530486 |
| authorships[7].affiliations[0].raw_affiliation_string | BC Cancer Agency, Vancouver, Canada |
| authorships[7].institutions[0].id | https://openalex.org/I1289530486 |
| authorships[7].institutions[0].ror | https://ror.org/03sfybe47 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I1289530486 |
| authorships[7].institutions[0].country_code | CA |
| authorships[7].institutions[0].display_name | BC Cancer Agency |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Helen McTaggart-Cowan |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | BC Cancer Agency, Vancouver, Canada |
| authorships[8].author.id | https://openalex.org/A5026941564 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-9594-0545 |
| authorships[8].author.display_name | Gillian E. Hanley |
| authorships[8].countries | CA |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[8].affiliations[0].raw_affiliation_string | University of British Columbia, Vancouver, BC, Canada |
| authorships[8].institutions[0].id | https://openalex.org/I141945490 |
| authorships[8].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[8].institutions[0].country_code | CA |
| authorships[8].institutions[0].display_name | University of British Columbia |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Gillian E. Hanley |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | University of British Columbia, Vancouver, BC, Canada |
| authorships[9].author.id | https://openalex.org/A5017562167 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-8903-0040 |
| authorships[9].author.display_name | Amirrtha Srikanthan |
| authorships[9].countries | CA |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I2800722420 |
| authorships[9].affiliations[0].raw_affiliation_string | Ottawa Hospital, Ottawa, Ontario, Canada |
| authorships[9].institutions[0].id | https://openalex.org/I2800722420 |
| authorships[9].institutions[0].ror | https://ror.org/03c62dg59 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I2800722420 |
| authorships[9].institutions[0].country_code | CA |
| authorships[9].institutions[0].display_name | Ottawa Hospital |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Amirrtha Srikanthan |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Ottawa Hospital, Ottawa, Ontario, Canada |
| authorships[10].author.id | https://openalex.org/A5028772059 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-2205-2683 |
| authorships[10].author.display_name | Mary A. De Vera |
| authorships[10].countries | CA |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[10].affiliations[0].raw_affiliation_string | University of British Columbia, Vancouver, BC, Canada |
| authorships[10].institutions[0].id | https://openalex.org/I141945490 |
| authorships[10].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[10].institutions[0].country_code | CA |
| authorships[10].institutions[0].display_name | University of British Columbia |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | Mary A. De Vera |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | University of British Columbia, Vancouver, BC, Canada |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://aacrjournals.org/cebp/article-pdf/doi/10.1158/1055-9965.EPI-25-0442/3622158/epi-25-0442.pdf |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Gravida and Birth Outcomes Prior to and after Diagnosis of Early Age–Onset Colorectal Cancer among Female Patients: Population-Based Epidemiologic Studies |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-23T05:10:03.516525 |
| primary_topic.id | https://openalex.org/T12103 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9958000183105469 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2730 |
| primary_topic.subfield.display_name | Oncology |
| primary_topic.display_name | Cancer Risks and Factors |
| related_works | https://openalex.org/W4315650970, https://openalex.org/W2118847041, https://openalex.org/W2024025088, https://openalex.org/W2016483411, https://openalex.org/W1982619745, https://openalex.org/W2403534611, https://openalex.org/W2167134322, https://openalex.org/W4393387432, https://openalex.org/W4238363529, https://openalex.org/W2419315711 |
| cited_by_count | 0 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1158/1055-9965.epi-25-0442 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S8391440 |
| best_oa_location.source.issn | 1055-9965, 1538-7755 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 1055-9965 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Cancer Epidemiology Biomarkers & Prevention |
| best_oa_location.source.host_organization | https://openalex.org/P4310320273 |
| best_oa_location.source.host_organization_name | American Association for Cancer Research |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320273 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://aacrjournals.org/cebp/article-pdf/doi/10.1158/1055-9965.EPI-25-0442/3622158/epi-25-0442.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cancer Epidemiology, Biomarkers & Prevention |
| best_oa_location.landing_page_url | https://doi.org/10.1158/1055-9965.epi-25-0442 |
| primary_location.id | doi:10.1158/1055-9965.epi-25-0442 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S8391440 |
| primary_location.source.issn | 1055-9965, 1538-7755 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1055-9965 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Cancer Epidemiology Biomarkers & Prevention |
| primary_location.source.host_organization | https://openalex.org/P4310320273 |
| primary_location.source.host_organization_name | American Association for Cancer Research |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320273 |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://aacrjournals.org/cebp/article-pdf/doi/10.1158/1055-9965.EPI-25-0442/3622158/epi-25-0442.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cancer Epidemiology, Biomarkers & Prevention |
| primary_location.landing_page_url | https://doi.org/10.1158/1055-9965.epi-25-0442 |
| publication_date | 2025-06-18 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2789852907, https://openalex.org/W2088559145, https://openalex.org/W2069182895, https://openalex.org/W2074654488, https://openalex.org/W2528498741, https://openalex.org/W4281847630, https://openalex.org/W3014481596, https://openalex.org/W4380987655, https://openalex.org/W4321609924, https://openalex.org/W4365460354, https://openalex.org/W4386824137, https://openalex.org/W2406650501, https://openalex.org/W2011966376, https://openalex.org/W2000225223, https://openalex.org/W2033554291, https://openalex.org/W2138634269, https://openalex.org/W2175607782, https://openalex.org/W3209369985, https://openalex.org/W4324066787, https://openalex.org/W4210820670, https://openalex.org/W2902500338, https://openalex.org/W4322768430, https://openalex.org/W2911624776, https://openalex.org/W2769732820 |
| referenced_works_count | 24 |
| abstract_inverted_index.0 | 168 |
| abstract_inverted_index.a | 50, 53, 113, 146, 230 |
| abstract_inverted_index.We | 48 |
| abstract_inverted_index.at | 128 |
| abstract_inverted_index.in | 150 |
| abstract_inverted_index.of | 64, 124, 148, 160, 167, 185, 212 |
| abstract_inverted_index.to | 26, 71, 85 |
| abstract_inverted_index.± | 132, 141 |
| abstract_inverted_index.(i) | 29, 87 |
| abstract_inverted_index.6.1 | 133 |
| abstract_inverted_index.6.3 | 142 |
| abstract_inverted_index.865 | 125 |
| abstract_inverted_index.95% | 171, 193 |
| abstract_inverted_index.Our | 23, 216 |
| abstract_inverted_index.The | 120 |
| abstract_inverted_index.and | 15, 34, 36, 42, 52, 73, 75, 101, 103, 109, 137, 203, 225 |
| abstract_inverted_index.for | 232, 239 |
| abstract_inverted_index.had | 155, 181 |
| abstract_inverted_index.not | 19 |
| abstract_inverted_index.the | 9, 30, 38, 88, 94, 105, 151, 158, 219 |
| abstract_inverted_index.was | 25 |
| abstract_inverted_index.yet | 12 |
| abstract_inverted_index.(OR, | 169, 191 |
| abstract_inverted_index.(age | 127 |
| abstract_inverted_index.(ii) | 37, 104 |
| abstract_inverted_index.1.82 | 156 |
| abstract_inverted_index.2005 | 70 |
| abstract_inverted_index.2017 | 72 |
| abstract_inverted_index.42.5 | 131 |
| abstract_inverted_index.age, | 198 |
| abstract_inverted_index.age- | 74 |
| abstract_inverted_index.been | 20 |
| abstract_inverted_index.data | 59 |
| abstract_inverted_index.five | 189 |
| abstract_inverted_index.from | 60, 69 |
| abstract_inverted_index.have | 18 |
| abstract_inverted_index.need | 231 |
| abstract_inverted_index.odds | 159, 184, 211 |
| abstract_inverted_index.over | 93, 112 |
| abstract_inverted_index.used | 84 |
| abstract_inverted_index.were | 83, 207 |
| abstract_inverted_index.with | 67, 135, 145, 163, 165, 179, 209, 242 |
| abstract_inverted_index.≥2 | 149 |
| abstract_inverted_index.(42.4 | 140 |
| abstract_inverted_index.0.23; | 192 |
| abstract_inverted_index.1.82; | 170 |
| abstract_inverted_index.8,291 | 138 |
| abstract_inverted_index.After | 175 |
| abstract_inverted_index.Early | 2 |
| abstract_inverted_index.Older | 197 |
| abstract_inverted_index.after | 16, 44 |
| abstract_inverted_index.birth | 187 |
| abstract_inverted_index.lower | 183, 199, 210 |
| abstract_inverted_index.rural | 201 |
| abstract_inverted_index.study | 55, 121, 217 |
| abstract_inverted_index.those | 164 |
| abstract_inverted_index.times | 157 |
| abstract_inverted_index.using | 56 |
| abstract_inverted_index.years | 190 |
| abstract_inverted_index.5-year | 95, 114, 152 |
| abstract_inverted_index.before | 14, 98 |
| abstract_inverted_index.births | 43, 110 |
| abstract_inverted_index.cancer | 5, 45, 99, 117, 176 |
| abstract_inverted_index.cohort | 54 |
| abstract_inverted_index.during | 8 |
| abstract_inverted_index.family | 237 |
| abstract_inverted_index.female | 240 |
| abstract_inverted_index.giving | 186 |
| abstract_inverted_index.health | 58, 224 |
| abstract_inverted_index.models | 82 |
| abstract_inverted_index.period | 97, 115, 154 |
| abstract_inverted_index.sample | 122 |
| abstract_inverted_index.within | 188 |
| abstract_inverted_index.years) | 134 |
| abstract_inverted_index.years, | 11 |
| abstract_inverted_index.British | 61 |
| abstract_inverted_index.Canada, | 63 |
| abstract_inverted_index.EAO-CRC | 35, 41, 68, 102, 108, 129, 136, 161, 180 |
| abstract_inverted_index.Females | 144 |
| abstract_inverted_index.Impact: | 227 |
| abstract_inverted_index.between | 32, 40, 90, 107, 222 |
| abstract_inverted_index.births. | 214 |
| abstract_inverted_index.complex | 220 |
| abstract_inverted_index.females | 65, 126, 178 |
| abstract_inverted_index.gravida | 33, 91, 147, 166 |
| abstract_inverted_index.greater | 204 |
| abstract_inverted_index.income, | 200 |
| abstract_inverted_index.strikes | 7 |
| abstract_inverted_index.support | 235 |
| abstract_inverted_index.years). | 143 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.EAO-CRC. | 226, 243 |
| abstract_inverted_index.Findings | 228 |
| abstract_inverted_index.Methods: | 47 |
| abstract_inverted_index.Results: | 119 |
| abstract_inverted_index.assessed | 92, 111 |
| abstract_inverted_index.compared | 162 |
| abstract_inverted_index.controls | 139 |
| abstract_inverted_index.examine: | 28 |
| abstract_inverted_index.indicate | 229 |
| abstract_inverted_index.logistic | 80 |
| abstract_inverted_index.patients | 241 |
| abstract_inverted_index.planning | 238 |
| abstract_inverted_index.prodrome | 96, 153 |
| abstract_inverted_index.studied. | 22 |
| abstract_inverted_index.(EAO-CRC) | 6 |
| abstract_inverted_index.Columbia, | 62 |
| abstract_inverted_index.conducted | 49 |
| abstract_inverted_index.consisted | 123 |
| abstract_inverted_index.controls. | 78 |
| abstract_inverted_index.diagnosed | 66 |
| abstract_inverted_index.diagnosis | 17, 100, 130 |
| abstract_inverted_index.evaluate: | 86 |
| abstract_inverted_index.following | 116 |
| abstract_inverted_index.interval, | 173, 195 |
| abstract_inverted_index.objective | 24 |
| abstract_inverted_index.addressing | 236 |
| abstract_inverted_index.associated | 208 |
| abstract_inverted_index.colorectal | 4 |
| abstract_inverted_index.confidence | 172, 194 |
| abstract_inverted_index.diagnosis, | 177 |
| abstract_inverted_index.diagnosis. | 46, 118 |
| abstract_inverted_index.healthcare | 205 |
| abstract_inverted_index.highlights | 218 |
| abstract_inverted_index.regression | 81 |
| abstract_inverted_index.residence, | 202 |
| abstract_inverted_index.thoroughly | 21 |
| abstract_inverted_index.Background: | 1 |
| abstract_inverted_index.age–onset | 3 |
| abstract_inverted_index.association | 89, 106 |
| abstract_inverted_index.cancer-free | 77 |
| abstract_inverted_index.pregnancies | 13 |
| abstract_inverted_index.sex-matched | 76 |
| abstract_inverted_index.utilization | 206 |
| abstract_inverted_index.Conclusions: | 215 |
| abstract_inverted_index.psychosocial | 234 |
| abstract_inverted_index.relationship | 31, 39, 221 |
| abstract_inverted_index.reproductive | 10, 223 |
| abstract_inverted_index.0.15–0.37). | 196 |
| abstract_inverted_index.1.19–2.78). | 174 |
| abstract_inverted_index.Multivariable | 79 |
| abstract_inverted_index.comprehensive | 233 |
| abstract_inverted_index.significantly | 182 |
| abstract_inverted_index.administrative | 57 |
| abstract_inverted_index.case–control | 51 |
| abstract_inverted_index.post-diagnosis | 213 |
| abstract_inverted_index.comprehensively | 27 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/1 |
| sustainable_development_goals[0].score | 0.5899999737739563 |
| sustainable_development_goals[0].display_name | No poverty |
| citation_normalized_percentile.value | 0.34546806 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |