Grey matter atrophy in patients with benign multiple sclerosis Article Swipe
Marja Niiranen
,
Juha Koikkalainen
,
Jyrki Lötjönen
,
Tuomas Selander
,
Antti Cajanus
,
Päivi Hartikainen
,
Sakari Simula
,
Ritva Vanninen
,
Anne M. Remes
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/brb3.2679
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/brb3.2679
Background Brain atrophy appears during the progression of multiple sclerosis (MS) and is associated with the disability caused by the disease. Methods We investigated global and regional grey matter (GM) and white matter (WM) volumes, WM lesion load, and corpus callosum index (CCI), in benign relapsing‐remitting MS (BRRMS, n = 35) with and without any treatment and compared those to aggressive relapsing‐remitting MS (ARRMS, n = 46). Structures were analyzed by using an automated MRI quantification tool (cNeuro®). Results The total brain and cerebral WM volumes were larger in BRRMS than in ARRMS ( p = .014, p = .017 respectively). In BRRMS, total brain volumes, regional GM volumes, and CCI were found similar whether or not disease‐modifying treatment (DMT) was used. The total ( p = .033), as well as subcortical ( p = .046) and deep WM ( p = .041) lesion load volumes were larger in BRRMS patients without DMT. Cortical GM volumes did not differ between BRRMS and ARRMS, but the volumes of total brain tissue ( p = .014) and thalami ( p = .003) were larger in patients with BRRMS compared to ARRMS. A positive correlation was found between CCI and whole‐brain volume in both BRRMS ( r = .73, p < .001) and ARRMS ( r = .80, p < .01). Conclusions Thalamic volume is the most prominent measure to differentiate BRRMS and ARRMS. Validation of automated quantification of CCI provides an additional applicable MRI biomarker to detect brain atrophy in MS.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/brb3.2679
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.2679
- OA Status
- gold
- Cited By
- 17
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4283700902
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4283700902Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/brb3.2679Digital Object Identifier
- Title
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Grey matter atrophy in patients with benign multiple sclerosisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-06-28Full publication date if available
- Authors
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Marja Niiranen, Juha Koikkalainen, Jyrki Lötjönen, Tuomas Selander, Antti Cajanus, Päivi Hartikainen, Sakari Simula, Ritva Vanninen, Anne M. RemesList of authors in order
- Landing page
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https://doi.org/10.1002/brb3.2679Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.2679Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.2679Direct OA link when available
- Concepts
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Atrophy, Multiple sclerosis, Grey matter, Medicine, Pathology, White matter, Magnetic resonance imaging, Radiology, ImmunologyTop concepts (fields/topics) attached by OpenAlex
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17Total citation count in OpenAlex
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2025: 6, 2024: 7, 2023: 3, 2022: 1Per-year citation counts (last 5 years)
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62Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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