Grhl3 promotes retention of epidermal cells under endocytic stress to maintain epidermal architecture in zebrafish Article Swipe
Mandar Phatak
,
Shruti H. Kulkarni
,
Lee B. Miles
,
Nazma Anjum
,
Sebastian Dworkin
,
Mahendra Sonawane
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pgen.1009823
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pgen.1009823
Epithelia such as epidermis cover large surfaces and are crucial for survival. Maintenance of tissue homeostasis by balancing cell proliferation, cell size, and cell extrusion ensures epidermal integrity. Although the mechanisms of cell extrusion are better understood, how epithelial cells that round up under developmental or perturbed genetic conditions are reintegrated in the epithelium to maintain homeostasis remains unclear. Here, we performed live imaging in zebrafish embryos to show that epidermal cells that round up due to membrane homeostasis defects in the absence of goosepimples/myosinVb (myoVb) function, are reintegrated into the epithelium. Transcriptome analysis and genetic interaction studies suggest that the transcription factor Grainyhead-like 3 (Grhl3) induces the retention of rounded cells by regulating E-cadherin levels. Moreover, Grhl3 facilitates the survival of MyoVb deficient embryos by regulating cell adhesion, cell retention, and epidermal architecture. Our analyses have unraveled a mechanism of retention of rounded cells and its importance in epithelial homeostasis.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pgen.1009823
- https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009823&type=printable
- OA Status
- gold
- Cited By
- 3
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3203626928
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3203626928Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.pgen.1009823Digital Object Identifier
- Title
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Grhl3 promotes retention of epidermal cells under endocytic stress to maintain epidermal architecture in zebrafishWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-27Full publication date if available
- Authors
-
Mandar Phatak, Shruti H. Kulkarni, Lee B. Miles, Nazma Anjum, Sebastian Dworkin, Mahendra SonawaneList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pgen.1009823Publisher landing page
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009823&type=printableDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009823&type=printableDirect OA link when available
- Concepts
-
Biology, Cell biology, Zebrafish, Homeostasis, Epidermis (zoology), Epidermal growth factor, Transcription factor, Cell adhesion, Epithelium, Cell, Cell culture, Genetics, Anatomy, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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66Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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