Growth Hormone Secretory Capacity Is Associated with Cardiac Morphology and Function in Overweight and Obese Patients: A Controlled, Cross-Sectional Study Article Swipe
Elena Gangitano
,
Giuseppe Bárbaro
,
Martina Susi
,
Rebecca Rossetti
,
Maria Elena Spoltore
,
Davide Masi
,
Rossella Tozzi
,
Stefania Mariani
,
Lucio Gnessi
,
Carla Lubrano
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/cells11152420
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/cells11152420
Obesity is associated with increased cardiovascular morbidity. Adult patients with growth hormone deficiency (GHD) show morpho-functional cardiological alterations. A total of 353 overweight/obese patients are enrolled in the period between 2009 and 2019 to assess the relationships between GH secretory capacity and the metabolic phenotype, cardiovascular risk factors, body composition and cardiac echocardiographic parameters. All patients underwent GHRH + arginine test to evaluate GH secretory capacity, DEXA for body composition assessment and transthoracic echocardiography. Blood samples are also collected for the evaluation of metabolic parameters. In total, 144 patients had GH deficiency and 209 patients had normal GH secretion. In comparing the two groups, we found significant differences in body fat distribution with predominantly visceral adipose tissue accumulation in GHD patients. Metabolic syndrome is more prevalent in the GHD group. In particular, fasting glycemia, triglycerides and systolic and diastolic blood pressure are found to be linearly correlated with GH secretory capacity. Epicardial fat thickness, E/A ratio and indexed ventricular mass are worse in the GHD group. In the population studied, metabolic phenotype, body composition, cardiovascular risk factors and cardiac morphology are found to be related to the GH secretory capacity. GH secretion in the obese patient seems to be an important determinant of metabolic health.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cells11152420
- https://www.mdpi.com/2073-4409/11/15/2420/pdf?version=1659928606
- OA Status
- gold
- Cited By
- 12
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4289986100
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4289986100Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cells11152420Digital Object Identifier
- Title
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Growth Hormone Secretory Capacity Is Associated with Cardiac Morphology and Function in Overweight and Obese Patients: A Controlled, Cross-Sectional StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-08-04Full publication date if available
- Authors
-
Elena Gangitano, Giuseppe Bárbaro, Martina Susi, Rebecca Rossetti, Maria Elena Spoltore, Davide Masi, Rossella Tozzi, Stefania Mariani, Lucio Gnessi, Carla LubranoList of authors in order
- Landing page
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https://doi.org/10.3390/cells11152420Publisher landing page
- PDF URL
-
https://www.mdpi.com/2073-4409/11/15/2420/pdf?version=1659928606Direct link to full text PDF
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-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2073-4409/11/15/2420/pdf?version=1659928606Direct OA link when available
- Concepts
-
Overweight, Medicine, Internal medicine, Endocrinology, Obesity, Adipose tissue, Diastole, Population, Blood pressure, Metabolic syndrome, Cardiology, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
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2025: 7, 2024: 2, 2023: 3Per-year citation counts (last 5 years)
- References (count)
-
66Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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