GSTM1 and Liver Iron Content in Children with Sickle Cell Anemia and Iron Overload Article Swipe
Latika Puri
,
Jonathan M. Flanagan
,
Guolian Kang
,
Juan Ding
,
Wenjian Bi
,
Beth McCarville
,
Ralf B. Loeffler
,
Aaryani Tipirneni‐Sajja
,
Martha Villavicencio
,
Kristine R. Crews
,
Claudia M. Hillenbrand
,
Jane S. Hankins
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/jcm8111878
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/jcm8111878
Chronic blood transfusions in patients with sickle cell anemia (SCA) cause iron overload, which occurs with a degree of interpatient variability in serum ferritin and liver iron content (LIC). Reasons for this variability are unclear and may be influenced by genes that regulate iron metabolism. We evaluated the association of the copy number of the glutathione S-transferase M1 (GSTM1) gene and degree of iron overload among patients with SCA. We compared LIC in 38 children with SCA and ≥12 lifetime erythrocyte transfusions stratified by GSTM1 genotype. Baseline LIC was measured using magnetic resonance imaging (MRI), R2*MRI within 3 months prior to, and again after, starting iron unloading therapy. After controlling for weight-corrected transfusion burden (mL/kg) and splenectomy, mean pre-chelation LIC (mg/g dry liver dry weight) was similar in all groups: GSTM1 wild-type (WT) (11.45, SD±6.8), heterozygous (8.2, SD±4.52), and homozygous GSTM1 deletion (GSTM1-null; 7.8, SD±6.9, p = 0.09). However, after >12 months of chelation, GSTM1-null genotype subjects had the least decrease in LIC compared to non-null genotype subjects (mean LIC change for GSTM1-null = 0.1 (SD±3.3); versus −0.3 (SD±3.0) and −1.9 (SD±4.9) mg/g liver dry weight for heterozygous and WT, respectively, p = 0.047). GSTM1 homozygous deletion may prevent effective chelation in children with SCA and iron overload.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm8111878
- https://www.mdpi.com/2077-0383/8/11/1878/pdf?version=1572952746
- OA Status
- gold
- Cited By
- 4
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2983211437
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2983211437Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/jcm8111878Digital Object Identifier
- Title
-
GSTM1 and Liver Iron Content in Children with Sickle Cell Anemia and Iron OverloadWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-11-05Full publication date if available
- Authors
-
Latika Puri, Jonathan M. Flanagan, Guolian Kang, Juan Ding, Wenjian Bi, Beth McCarville, Ralf B. Loeffler, Aaryani Tipirneni‐Sajja, Martha Villavicencio, Kristine R. Crews, Claudia M. Hillenbrand, Jane S. HankinsList of authors in order
- Landing page
-
https://doi.org/10.3390/jcm8111878Publisher landing page
- PDF URL
-
https://www.mdpi.com/2077-0383/8/11/1878/pdf?version=1572952746Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2077-0383/8/11/1878/pdf?version=1572952746Direct OA link when available
- Concepts
-
Medicine, Anemia, Dietary iron, Sickle cell anemia, Internal medicine, Gastroenterology, Iron deficiency, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 1, 2022: 1, 2021: 1, 2020: 1Per-year citation counts (last 5 years)
- References (count)
-
27Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2983211437 |
|---|---|
| doi | https://doi.org/10.3390/jcm8111878 |
| ids.doi | https://doi.org/10.3390/jcm8111878 |
| ids.mag | 2983211437 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/31694285 |
| ids.openalex | https://openalex.org/W2983211437 |
| fwci | 0.55831479 |
| type | article |
| title | GSTM1 and Liver Iron Content in Children with Sickle Cell Anemia and Iron Overload |
| biblio.issue | 11 |
| biblio.volume | 8 |
| biblio.last_page | 1878 |
| biblio.first_page | 1878 |
| topics[0].id | https://openalex.org/T10554 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9995999932289124 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2716 |
| topics[0].subfield.display_name | Genetics |
| topics[0].display_name | Hemoglobinopathies and Related Disorders |
| topics[1].id | https://openalex.org/T10452 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9987000226974487 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2720 |
| topics[1].subfield.display_name | Hematology |
| topics[1].display_name | Iron Metabolism and Disorders |
| topics[2].id | https://openalex.org/T10915 |
| topics[2].field.id | https://openalex.org/fields/29 |
| topics[2].field.display_name | Nursing |
| topics[2].score | 0.9896000027656555 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2916 |
| topics[2].subfield.display_name | Nutrition and Dietetics |
| topics[2].display_name | Trace Elements in Health |
| is_xpac | False |
| apc_list.value | 2400 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2598 |
| apc_paid.value | 2400 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2598 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.9551829099655151 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C2778248108 |
| concepts[1].level | 2 |
| concepts[1].score | 0.5839095115661621 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q5445 |
| concepts[1].display_name | Anemia |
| concepts[2].id | https://openalex.org/C3017702006 |
| concepts[2].level | 4 |
| concepts[2].score | 0.5742061138153076 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1313081 |
| concepts[2].display_name | Dietary iron |
| concepts[3].id | https://openalex.org/C2778620579 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5165766477584839 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q185034 |
| concepts[3].display_name | Sickle cell anemia |
| concepts[4].id | https://openalex.org/C126322002 |
| concepts[4].level | 1 |
| concepts[4].score | 0.34014734625816345 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[4].display_name | Internal medicine |
| concepts[5].id | https://openalex.org/C90924648 |
| concepts[5].level | 1 |
| concepts[5].score | 0.3245263695716858 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q120569 |
| concepts[5].display_name | Gastroenterology |
| concepts[6].id | https://openalex.org/C2777417653 |
| concepts[6].level | 3 |
| concepts[6].score | 0.3019406795501709 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1313081 |
| concepts[6].display_name | Iron deficiency |
| concepts[7].id | https://openalex.org/C2779134260 |
| concepts[7].level | 2 |
| concepts[7].score | 0.1502799689769745 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[7].display_name | Disease |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.9551829099655151 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/anemia |
| keywords[1].score | 0.5839095115661621 |
| keywords[1].display_name | Anemia |
| keywords[2].id | https://openalex.org/keywords/dietary-iron |
| keywords[2].score | 0.5742061138153076 |
| keywords[2].display_name | Dietary iron |
| keywords[3].id | https://openalex.org/keywords/sickle-cell-anemia |
| keywords[3].score | 0.5165766477584839 |
| keywords[3].display_name | Sickle cell anemia |
| keywords[4].id | https://openalex.org/keywords/internal-medicine |
| keywords[4].score | 0.34014734625816345 |
| keywords[4].display_name | Internal medicine |
| keywords[5].id | https://openalex.org/keywords/gastroenterology |
| keywords[5].score | 0.3245263695716858 |
| keywords[5].display_name | Gastroenterology |
| keywords[6].id | https://openalex.org/keywords/iron-deficiency |
| keywords[6].score | 0.3019406795501709 |
| keywords[6].display_name | Iron deficiency |
| keywords[7].id | https://openalex.org/keywords/disease |
| keywords[7].score | 0.1502799689769745 |
| keywords[7].display_name | Disease |
| language | en |
| locations[0].id | doi:10.3390/jcm8111878 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2737969411 |
| locations[0].source.issn | 2077-0383 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2077-0383 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal of Clinical Medicine |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2077-0383/8/11/1878/pdf?version=1572952746 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Clinical Medicine |
| locations[0].landing_page_url | https://doi.org/10.3390/jcm8111878 |
| locations[1].id | pmid:31694285 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of clinical medicine |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/31694285 |
| locations[2].id | pmh:oai:doaj.org/article:4ab53f2df77d4b29a049feb0d7e31113 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Journal of Clinical Medicine, Vol 8, Iss 11, p 1878 (2019) |
| locations[2].landing_page_url | https://doaj.org/article/4ab53f2df77d4b29a049feb0d7e31113 |
| locations[3].id | pmh:oai:europepmc.org:5896492 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400806 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Europe PMC (PubMed Central) |
| locations[3].source.host_organization | https://openalex.org/I1303153112 |
| locations[3].source.host_organization_name | European Bioinformatics Institute |
| locations[3].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/6912836 |
| locations[4].id | pmh:oai:mdpi.com:/2077-0383/8/11/1878/ |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306400947 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | True |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | MDPI (MDPI AG) |
| locations[4].source.host_organization | https://openalex.org/I4210097602 |
| locations[4].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[4].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[4].license | cc-by |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/cc-by |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Journal of Clinical Medicine |
| locations[4].landing_page_url | http://dx.doi.org/10.3390/jcm8111878 |
| locations[5].id | pmh:oai:unsworks.library.unsw.edu.au:1959.4/unsworks_74099 |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S4306401737 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | UNSWorks (University of New South Wales, Sydney, Australia) |
| locations[5].source.host_organization | https://openalex.org/I40053085 |
| locations[5].source.host_organization_name | Australian Defence Force Academy |
| locations[5].source.host_organization_lineage | https://openalex.org/I40053085 |
| locations[5].license | cc-by |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | http://purl.org/coar/resource_type/c_6501 |
| locations[5].license_id | https://openalex.org/licenses/cc-by |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | Journal of Clinical Medicine, 8, 11, 1878 |
| locations[5].landing_page_url | http://hdl.handle.net/1959.4/unsworks_74099 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5081057331 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Latika Puri |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Hematology, St Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[0].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[0].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Latika Puri |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Hematology, St Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[1].author.id | https://openalex.org/A5102939345 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-1330-6618 |
| authorships[1].author.display_name | Jonathan M. Flanagan |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I181547552 |
| authorships[1].affiliations[0].raw_affiliation_string | Division of Hematology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA |
| authorships[1].institutions[0].id | https://openalex.org/I181547552 |
| authorships[1].institutions[0].ror | https://ror.org/02pttbw34 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I181547552, https://openalex.org/I2801539370 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Baylor College of Medicine |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Jonathan M. Flanagan |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Division of Hematology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA |
| authorships[2].author.id | https://openalex.org/A5069587739 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-6102-0115 |
| authorships[2].author.display_name | Guolian Kang |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[2].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[2].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Guolian Kang |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[3].author.id | https://openalex.org/A5065615492 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-9981-6530 |
| authorships[3].author.display_name | Juan Ding |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[3].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[3].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Juan Ding |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[4].author.id | https://openalex.org/A5061775997 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-5108-9311 |
| authorships[4].author.display_name | Wenjian Bi |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I27837315 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA |
| authorships[4].institutions[0].id | https://openalex.org/I27837315 |
| authorships[4].institutions[0].ror | https://ror.org/00jmfr291 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I27837315 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | University of Michigan |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Wenjian Bi |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA |
| authorships[5].author.id | https://openalex.org/A5027333697 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Beth McCarville |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[5].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[5].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Beth M. McCarville |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[6].author.id | https://openalex.org/A5062633620 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-0482-5486 |
| authorships[6].author.display_name | Ralf B. Loeffler |
| authorships[6].countries | AU |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I31746571 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Research Imaging, University of New South Wales, Randwick, NSW 2052, Australia |
| authorships[6].institutions[0].id | https://openalex.org/I31746571 |
| authorships[6].institutions[0].ror | https://ror.org/03r8z3t63 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I31746571 |
| authorships[6].institutions[0].country_code | AU |
| authorships[6].institutions[0].display_name | UNSW Sydney |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Ralf B. Loeffler |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Research Imaging, University of New South Wales, Randwick, NSW 2052, Australia |
| authorships[7].author.id | https://openalex.org/A5019708641 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-3246-8711 |
| authorships[7].author.display_name | Aaryani Tipirneni‐Sajja |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I94658018 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Biomedical Engineering, University of Memphis, Memphis, TN 38105, USA |
| authorships[7].institutions[0].id | https://openalex.org/I94658018 |
| authorships[7].institutions[0].ror | https://ror.org/01cq23130 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I94658018 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | University of Memphis |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Aaryani Tipirneni-Sajja |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Biomedical Engineering, University of Memphis, Memphis, TN 38105, USA |
| authorships[8].author.id | https://openalex.org/A5109396838 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Martha Villavicencio |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Hematology, St Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[8].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[8].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Martha Villavicencio |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Hematology, St Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[9].author.id | https://openalex.org/A5085620590 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-7558-558X |
| authorships[9].author.display_name | Kristine R. Crews |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[9].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[9].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Kristine R. Crews |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[10].author.id | https://openalex.org/A5027197682 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-8694-2178 |
| authorships[10].author.display_name | Claudia M. Hillenbrand |
| authorships[10].countries | AU |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I31746571 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Research Imaging, University of New South Wales, Randwick, NSW 2052, Australia |
| authorships[10].institutions[0].id | https://openalex.org/I31746571 |
| authorships[10].institutions[0].ror | https://ror.org/03r8z3t63 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I31746571 |
| authorships[10].institutions[0].country_code | AU |
| authorships[10].institutions[0].display_name | UNSW Sydney |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Claudia M. Hillenbrand |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Research Imaging, University of New South Wales, Randwick, NSW 2052, Australia |
| authorships[11].author.id | https://openalex.org/A5036901969 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-4439-7321 |
| authorships[11].author.display_name | Jane S. Hankins |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I1313298211 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Hematology, St Jude Children's Research Hospital, Memphis, TN 38105, USA |
| authorships[11].institutions[0].id | https://openalex.org/I1313298211 |
| authorships[11].institutions[0].ror | https://ror.org/02r3e0967 |
| authorships[11].institutions[0].type | healthcare |
| authorships[11].institutions[0].lineage | https://openalex.org/I1313298211, https://openalex.org/I2802152183 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | St. Jude Children's Research Hospital |
| authorships[11].author_position | last |
| authorships[11].raw_author_name | Jane S. Hankins |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Hematology, St Jude Children's Research Hospital, Memphis, TN 38105, USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2077-0383/8/11/1878/pdf?version=1572952746 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | GSTM1 and Liver Iron Content in Children with Sickle Cell Anemia and Iron Overload |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10554 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9995999932289124 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2716 |
| primary_topic.subfield.display_name | Genetics |
| primary_topic.display_name | Hemoglobinopathies and Related Disorders |
| related_works | https://openalex.org/W2475727517, https://openalex.org/W1657480157, https://openalex.org/W3030130454, https://openalex.org/W1480331690, https://openalex.org/W1999048183, https://openalex.org/W3164326813, https://openalex.org/W2001651741, https://openalex.org/W2109766098, https://openalex.org/W2126060189, https://openalex.org/W2087040399 |
| cited_by_count | 4 |
| counts_by_year[0].year | 2023 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2022 |
| counts_by_year[1].cited_by_count | 1 |
| counts_by_year[2].year | 2021 |
| counts_by_year[2].cited_by_count | 1 |
| counts_by_year[3].year | 2020 |
| counts_by_year[3].cited_by_count | 1 |
| locations_count | 6 |
| best_oa_location.id | doi:10.3390/jcm8111878 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2737969411 |
| best_oa_location.source.issn | 2077-0383 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2077-0383 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Journal of Clinical Medicine |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2077-0383/8/11/1878/pdf?version=1572952746 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Clinical Medicine |
| best_oa_location.landing_page_url | https://doi.org/10.3390/jcm8111878 |
| primary_location.id | doi:10.3390/jcm8111878 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2737969411 |
| primary_location.source.issn | 2077-0383 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2077-0383 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of Clinical Medicine |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2077-0383/8/11/1878/pdf?version=1572952746 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Clinical Medicine |
| primary_location.landing_page_url | https://doi.org/10.3390/jcm8111878 |
| publication_date | 2019-11-05 |
| publication_year | 2019 |
| referenced_works | https://openalex.org/W1498156640, https://openalex.org/W2113774399, https://openalex.org/W2620536820, https://openalex.org/W1970880446, https://openalex.org/W2049224577, https://openalex.org/W2007568654, https://openalex.org/W2042251812, https://openalex.org/W2003392107, https://openalex.org/W1529376906, https://openalex.org/W1989164659, https://openalex.org/W2048196545, https://openalex.org/W2063871118, https://openalex.org/W2053488151, https://openalex.org/W2063844762, https://openalex.org/W2800050006, https://openalex.org/W1506899620, https://openalex.org/W2951491503, https://openalex.org/W2128493325, https://openalex.org/W2534685365, https://openalex.org/W2000233461, https://openalex.org/W2073632465, https://openalex.org/W2038962358, https://openalex.org/W2056910995, https://openalex.org/W2496479297, https://openalex.org/W2071086229, https://openalex.org/W2029456630, https://openalex.org/W1994019078 |
| referenced_works_count | 27 |
| abstract_inverted_index.3 | 97 |
| abstract_inverted_index.= | 146, 173, 192 |
| abstract_inverted_index.a | 16 |
| abstract_inverted_index.p | 145, 191 |
| abstract_inverted_index.38 | 73 |
| abstract_inverted_index.M1 | 57 |
| abstract_inverted_index.We | 45, 69 |
| abstract_inverted_index.be | 37 |
| abstract_inverted_index.by | 39, 83 |
| abstract_inverted_index.in | 3, 21, 72, 127, 161, 201 |
| abstract_inverted_index.of | 18, 49, 53, 62, 152 |
| abstract_inverted_index.to | 164 |
| abstract_inverted_index.0.1 | 174 |
| abstract_inverted_index.LIC | 71, 87, 119, 162, 169 |
| abstract_inverted_index.SCA | 76, 204 |
| abstract_inverted_index.WT, | 189 |
| abstract_inverted_index.all | 128 |
| abstract_inverted_index.and | 24, 35, 60, 77, 101, 115, 138, 179, 188, 205 |
| abstract_inverted_index.are | 33 |
| abstract_inverted_index.dry | 121, 123, 184 |
| abstract_inverted_index.for | 30, 110, 171, 186 |
| abstract_inverted_index.had | 157 |
| abstract_inverted_index.may | 36, 197 |
| abstract_inverted_index.the | 47, 50, 54, 158 |
| abstract_inverted_index.to, | 100 |
| abstract_inverted_index.was | 88, 125 |
| abstract_inverted_index.(WT) | 132 |
| abstract_inverted_index.7.8, | 143 |
| abstract_inverted_index.SCA. | 68 |
| abstract_inverted_index.cell | 7 |
| abstract_inverted_index.copy | 51 |
| abstract_inverted_index.gene | 59 |
| abstract_inverted_index.iron | 11, 26, 43, 63, 105, 206 |
| abstract_inverted_index.mean | 117 |
| abstract_inverted_index.mg/g | 182 |
| abstract_inverted_index.that | 41 |
| abstract_inverted_index.this | 31 |
| abstract_inverted_index.with | 5, 15, 67, 75, 203 |
| abstract_inverted_index.(8.2, | 136 |
| abstract_inverted_index.(SCA) | 9 |
| abstract_inverted_index.(mean | 168 |
| abstract_inverted_index.(mg/g | 120 |
| abstract_inverted_index.After | 108 |
| abstract_inverted_index.GSTM1 | 84, 130, 140, 194 |
| abstract_inverted_index.after | 149 |
| abstract_inverted_index.again | 102 |
| abstract_inverted_index.among | 65 |
| abstract_inverted_index.blood | 1 |
| abstract_inverted_index.cause | 10 |
| abstract_inverted_index.genes | 40 |
| abstract_inverted_index.least | 159 |
| abstract_inverted_index.liver | 25, 122, 183 |
| abstract_inverted_index.prior | 99 |
| abstract_inverted_index.serum | 22 |
| abstract_inverted_index.using | 90 |
| abstract_inverted_index.which | 13 |
| abstract_inverted_index.≥12 | 78 |
| abstract_inverted_index.>12 | 150 |
| abstract_inverted_index.(LIC). | 28 |
| abstract_inverted_index.(MRI), | 94 |
| abstract_inverted_index.0.09). | 147 |
| abstract_inverted_index.R2*MRI | 95 |
| abstract_inverted_index.after, | 103 |
| abstract_inverted_index.anemia | 8 |
| abstract_inverted_index.burden | 113 |
| abstract_inverted_index.change | 170 |
| abstract_inverted_index.degree | 17, 61 |
| abstract_inverted_index.months | 98, 151 |
| abstract_inverted_index.number | 52 |
| abstract_inverted_index.occurs | 14 |
| abstract_inverted_index.sickle | 6 |
| abstract_inverted_index.versus | 176 |
| abstract_inverted_index.weight | 185 |
| abstract_inverted_index.within | 96 |
| abstract_inverted_index.−0.3 | 177 |
| abstract_inverted_index.−1.9 | 180 |
| abstract_inverted_index.(11.45, | 133 |
| abstract_inverted_index.(GSTM1) | 58 |
| abstract_inverted_index.(mL/kg) | 114 |
| abstract_inverted_index.0.047). | 193 |
| abstract_inverted_index.Chronic | 0 |
| abstract_inverted_index.Reasons | 29 |
| abstract_inverted_index.content | 27 |
| abstract_inverted_index.groups: | 129 |
| abstract_inverted_index.imaging | 93 |
| abstract_inverted_index.prevent | 198 |
| abstract_inverted_index.similar | 126 |
| abstract_inverted_index.unclear | 34 |
| abstract_inverted_index.weight) | 124 |
| abstract_inverted_index.Baseline | 86 |
| abstract_inverted_index.However, | 148 |
| abstract_inverted_index.SD±6.9, | 144 |
| abstract_inverted_index.children | 74, 202 |
| abstract_inverted_index.compared | 70, 163 |
| abstract_inverted_index.decrease | 160 |
| abstract_inverted_index.deletion | 141, 196 |
| abstract_inverted_index.ferritin | 23 |
| abstract_inverted_index.genotype | 155, 166 |
| abstract_inverted_index.lifetime | 79 |
| abstract_inverted_index.magnetic | 91 |
| abstract_inverted_index.measured | 89 |
| abstract_inverted_index.non-null | 165 |
| abstract_inverted_index.overload | 64 |
| abstract_inverted_index.patients | 4, 66 |
| abstract_inverted_index.regulate | 42 |
| abstract_inverted_index.starting | 104 |
| abstract_inverted_index.subjects | 156, 167 |
| abstract_inverted_index.therapy. | 107 |
| abstract_inverted_index.(SD±3.0) | 178 |
| abstract_inverted_index.(SD±4.9) | 181 |
| abstract_inverted_index.SD±6.8), | 134 |
| abstract_inverted_index.chelation | 200 |
| abstract_inverted_index.effective | 199 |
| abstract_inverted_index.evaluated | 46 |
| abstract_inverted_index.genotype. | 85 |
| abstract_inverted_index.overload, | 12 |
| abstract_inverted_index.overload. | 207 |
| abstract_inverted_index.resonance | 92 |
| abstract_inverted_index.unloading | 106 |
| abstract_inverted_index.wild-type | 131 |
| abstract_inverted_index.(SD±3.3); | 175 |
| abstract_inverted_index.GSTM1-null | 154, 172 |
| abstract_inverted_index.SD±4.52), | 137 |
| abstract_inverted_index.chelation, | 153 |
| abstract_inverted_index.homozygous | 139, 195 |
| abstract_inverted_index.influenced | 38 |
| abstract_inverted_index.stratified | 82 |
| abstract_inverted_index.association | 48 |
| abstract_inverted_index.controlling | 109 |
| abstract_inverted_index.erythrocyte | 80 |
| abstract_inverted_index.glutathione | 55 |
| abstract_inverted_index.metabolism. | 44 |
| abstract_inverted_index.transfusion | 112 |
| abstract_inverted_index.variability | 20, 32 |
| abstract_inverted_index.(GSTM1-null; | 142 |
| abstract_inverted_index.heterozygous | 135, 187 |
| abstract_inverted_index.interpatient | 19 |
| abstract_inverted_index.splenectomy, | 116 |
| abstract_inverted_index.transfusions | 2, 81 |
| abstract_inverted_index.S-transferase | 56 |
| abstract_inverted_index.pre-chelation | 118 |
| abstract_inverted_index.respectively, | 190 |
| abstract_inverted_index.weight-corrected | 111 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5081057331 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I1313298211 |
| citation_normalized_percentile.value | 0.67483974 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |