Gut microbiome in paediatric short bowel syndrome: a systematic review and sequencing re-analysis Article Swipe

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Jemma Cleminson , Gregory R. Young , David I. Campbell , Fiona Campbell , Andrew R. Gennery , Janet Berrington , Christopher J. Stewart ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1038/s41390-025-04083-0

Impact Children with short bowel syndrome depend on parenteral nutrition, which carries significant risks. Short bowel syndrome patients show reduced gut microbial diversity, increased inflammation-associated bacteria, and fewer beneficial bacteria. This is the first systematic review and meta-analysis examining the gut microbiome in children with short bowel syndrome. The review demonstrated significantly lower bacterial diversity and richness in children with short bowel syndrome, regardless of achievement of intestinal autonomy. Diversity and richness were greater in children who achieved intestinal autonomy than those on parenteral nutrition, though not statistically significant. Larger studies adjusting for confounding factors may identify future therapeutic strategies.

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Short bowel syndrome Microbiome Parenteral nutrition Confounding Intestinal Microbiome Medicine Diversity (politics) Gut flora Internal medicine Intensive care medicine Immunology Biology Bioinformatics Anthropology Sociology

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Type: review
Language: en
Landing Page: https://doi.org/10.1038/s41390-025-04083-0
PDF: https://www.nature.com/articles/s41390-025-04083-0.pdf
OA Status: hybrid
References: 29
Related Works: 10
OpenAlex ID: https://openalex.org/W4410139712

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OpenAlex ID: https://openalex.org/W4410139712

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DOI: https://doi.org/10.1038/s41390-025-04083-0

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Title: Gut microbiome in paediatric short bowel syndrome: a systematic review and sequencing re-analysis

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Type: review

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Language: en

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Publication year: 2025

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Publication date: 2025-05-07

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Authors: Jemma Cleminson, Gregory R. Young, David I. Campbell, Fiona Campbell, Andrew R. Gennery, Janet Berrington, Christopher J. Stewart

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Landing page: https://doi.org/10.1038/s41390-025-04083-0

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PDF URL: https://www.nature.com/articles/s41390-025-04083-0.pdf

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OA status: hybrid

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OA URL: https://www.nature.com/articles/s41390-025-04083-0.pdf

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Concepts: Short bowel syndrome, Microbiome, Parenteral nutrition, Confounding, Intestinal Microbiome, Medicine, Diversity (politics), Gut flora, Internal medicine, Intensive care medicine, Immunology, Biology, Bioinformatics, Anthropology, Sociology

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References (count): 29

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