Gut Microbiota, Metabolome, and Body Composition Signatures of Response to Therapy in Patients with Advanced Melanoma Article Swipe
G. Vandoni
,
Federica D’Amico
,
Marco Fabbrini
,
Luigi Mariani
,
Sabina Sieri
,
Amanda Casirati
,
Lorenza Di Guardo
,
Michele Del Vecchio
,
Andrea Anichini
,
Roberta Mortarini
,
Francesco Sgambelluri
,
Giuseppe Celano
,
Nadia Serale
,
Maria De Angelis
,
Patrizia Brigidi
,
Cecilia Gavazzi
,
Silvia Turroni
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms241411611
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms241411611
Despite the recent breakthroughs in targeted and immunotherapy for melanoma, the overall survival rate remains low. In recent years, considerable attention has been paid to the gut microbiota and other modifiable patient factors (e.g., diet and body composition), though their role in influencing therapeutic responses has yet to be defined. Here, we characterized a cohort of 31 patients with unresectable IIIC-IV-stage cutaneous melanoma prior to initiation of targeted or first-line immunotherapy via the following methods: (i) fecal microbiome and metabolome via 16S rRNA amplicon sequencing and gas chromatography/mass spectrometry, respectively, and (ii) anthropometry, body composition, nutritional status, physical activity, biochemical parameters, and immunoprofiling. According to our data, patients subsequently classified as responders were obese (i.e., with high body mass index and high levels of total, visceral, subcutaneous, and intramuscular adipose tissue), non-sarcopenic, and enriched in certain fecal taxa (e.g., Phascolarctobacterium) and metabolites (e.g., anethole), which were potentially endowed with immunostimulatory and oncoprotective activities. On the other hand, non-response was associated with increased proportions of Streptococcus, Actinomyces, Veillonella, Dorea, Fusobacterium, higher neutrophil levels (and a higher neutrophil-to-lymphocyte ratio), and higher fecal levels of butyric acid and its esters, which also correlated with decreased survival. This exploratory study provides an integrated list of potential early prognostic biomarkers that could improve the clinical management of patients with advanced melanoma, in particular by guiding the design of adjuvant therapeutic strategies to improve treatment response and support long-term health improvement.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms241411611
- https://www.mdpi.com/1422-0067/24/14/11611/pdf?version=1689690988
- OA Status
- gold
- Cited By
- 13
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4384822656
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4384822656Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms241411611Digital Object Identifier
- Title
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Gut Microbiota, Metabolome, and Body Composition Signatures of Response to Therapy in Patients with Advanced MelanomaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-07-18Full publication date if available
- Authors
-
G. Vandoni, Federica D’Amico, Marco Fabbrini, Luigi Mariani, Sabina Sieri, Amanda Casirati, Lorenza Di Guardo, Michele Del Vecchio, Andrea Anichini, Roberta Mortarini, Francesco Sgambelluri, Giuseppe Celano, Nadia Serale, Maria De Angelis, Patrizia Brigidi, Cecilia Gavazzi, Silvia TurroniList of authors in order
- Landing page
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https://doi.org/10.3390/ijms241411611Publisher landing page
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https://www.mdpi.com/1422-0067/24/14/11611/pdf?version=1689690988Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/1422-0067/24/14/11611/pdf?version=1689690988Direct OA link when available
- Concepts
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Metabolome, Melanoma, Fusobacterium, Microbiome, Medicine, Internal medicine, Gut flora, Biology, Physiology, Immunology, Bioinformatics, Cancer research, Metabolite, Genetics, Bacteria, BacteroidesTop concepts (fields/topics) attached by OpenAlex
- Cited by
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13Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 11Per-year citation counts (last 5 years)
- References (count)
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69Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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