Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions Article Swipe
Britta De Pessemier
,
Lynda Grine
,
Melanie Debaere
,
Aglaya Maes
,
Bernhard Paetzold
,
Chris Callewaert
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/microorganisms9020353
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/microorganisms9020353
The microbiome plays an important role in a wide variety of skin disorders. Not only is the skin microbiome altered, but also surprisingly many skin diseases are accompanied by an altered gut microbiome. The microbiome is a key regulator for the immune system, as it aims to maintain homeostasis by communicating with tissues and organs in a bidirectional manner. Hence, dysbiosis in the skin and/or gut microbiome is associated with an altered immune response, promoting the development of skin diseases, such as atopic dermatitis, psoriasis, acne vulgaris, dandruff, and even skin cancer. Here, we focus on the associations between the microbiome, diet, metabolites, and immune responses in skin pathologies. This review describes an exhaustive list of common skin conditions with associated dysbiosis in the skin microbiome as well as the current body of evidence on gut microbiome dysbiosis, dietary links, and their interplay with skin conditions. An enhanced understanding of the local skin and gut microbiome including the underlying mechanisms is necessary to shed light on the microbial involvement in human skin diseases and to develop new therapeutic approaches.
Related Topics
Concepts
Microbiome
Dysbiosis
Atopic dermatitis
Psoriasis
Immune system
Biology
Immunology
Human skin
Acne
Human Microbiome Project
Human microbiome
Bioinformatics
Genetics
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/microorganisms9020353
- https://www.mdpi.com/2076-2607/9/2/353/pdf?version=1614070633
- OA Status
- gold
- Cited By
- 495
- References
- 362
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3126150139
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3126150139Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/microorganisms9020353Digital Object Identifier
- Title
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Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin ConditionsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-02-11Full publication date if available
- Authors
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Britta De Pessemier, Lynda Grine, Melanie Debaere, Aglaya Maes, Bernhard Paetzold, Chris CallewaertList of authors in order
- Landing page
-
https://doi.org/10.3390/microorganisms9020353Publisher landing page
- PDF URL
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https://www.mdpi.com/2076-2607/9/2/353/pdf?version=1614070633Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2076-2607/9/2/353/pdf?version=1614070633Direct OA link when available
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Microbiome, Dysbiosis, Atopic dermatitis, Psoriasis, Immune system, Biology, Immunology, Human skin, Acne, Human Microbiome Project, Human microbiome, Bioinformatics, GeneticsTop concepts (fields/topics) attached by OpenAlex
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495Total citation count in OpenAlex
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2025: 142, 2024: 145, 2023: 112, 2022: 72, 2021: 23Per-year citation counts (last 5 years)
- References (count)
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362Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5013208629 |
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| corresponding_institution_ids | https://openalex.org/I32597200 |
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| citation_normalized_percentile.is_in_top_10_percent | True |