H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas Article Swipe

PDF

María Belén Garcia-Fabiani , Santiago Haase , Kaushik Banerjee , Ziwen Zhu , Brandon L. McClellan , Anzar Mujeeb , Y Li , Claire E. Tronrud , María L. Varela , Molly E.J. West , Jin Yü , Padma Kadiyala , Ayman Taher , Felipe J. Núñez , Mahmoud S. Alghamri , Andrea Comba , Flor Mendez , Alejandro J. Nicola Candia , Brittany M. Salazar , Fernando M. Núñez , Marta Edwards , Tingting Qin , Rodrigo T. Cartaxo , Michael Niculcea , Carl Koschmann , Sriram Venneti , Montserrat Puigdelloses Vallcorba , Emon Nasajpour , Giulia Pericoli , Maria Vinci , Claudia L. Kleinman , Nada Jabado , James P. Chandler , Adam M. Sonabend , Michael DeCuypere , Dolores Hambardzumyan , Laura M. Prolo , Kelly B. Mahaney , Gerald A. Grant , Claudia Petritsch , Joshua D. Welch , Maureen A. Sartor , P R Lowenstein , María G. Castro ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1101/2023.06.13.544658

Diffuse hemispheric glioma (DHG), H3 G34-mutant, representing 9-15% of cases, are aggressive Central Nervous System (CNS) tumors with poor prognosis. This study examines the role of epigenetic reprogramming of the immune microenvironment and the response to immune-mediated therapies in G34-mutant DHG. To this end, we utilized human G34-mutant DHG biopsies, primary G34-mutant DHG cultures, and genetically engineered G34-mutant mouse models (GEMMs). Our findings show that the G34 mutation alters histone marks’ deposition at promoter and enhancer regions, leading to the activation of the JAK/STAT pathway, which in turn results in an immune-permissive tumor microenvironment. The implementation of Ad-TK/Ad-Flt3L immunostimulatory gene therapy significantly improved median survival, and lead to over 50% long term survivors. Upon tumor rechallenge in the contralateral hemisphere without any additional treatment, the long-term survivors exhibited robust anti-tumor immunity and immunological memory. These results indicate that immune-mediated therapies hold significant potential for clinical translation in treating patients harboring H3.3-G34 mutant DHGs, offering a promising strategy for improving outcomes in this challenging cancer subtype affecting adolescents and young adults (AYA). STATEMENT OF SIGNIFICANCE This study uncovers the role of the H3.3-G34 mutation in reprogramming the tumor immune microenvironment in diffuse hemispheric gliomas. Our findings support the implementation of precision medicine informed immunotherapies, aiming at improving enhanced therapeutic outcomes in adolescents and young adults harboring H3.3-G34 mutant DHGs.

Related Topics

Concepts

Reprogramming Epigenetics Mutation Gene Immune system Biology Genetics Cancer research Genetic enhancement Medicine Bioinformatics

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.1101/2023.06.13.544658
PDF: https://www.biorxiv.org/content/biorxiv/early/2023/06/13/2023.06.13.544658.full.pdf
OA Status: green
Cited By: 6
References: 94
Related Works: 10
OpenAlex ID: https://openalex.org/W4380624299

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4380624299

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1101/2023.06.13.544658

Digital Object Identifier
Title: H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2023

Year of publication
Publication date: 2023-06-13

Full publication date if available
Authors: María Belén Garcia-Fabiani, Santiago Haase, Kaushik Banerjee, Ziwen Zhu, Brandon L. McClellan, Anzar Mujeeb, Y Li, Claire E. Tronrud, María L. Varela, Molly E.J. West, Jin Yü, Padma Kadiyala, Ayman Taher, Felipe J. Núñez, Mahmoud S. Alghamri, Andrea Comba, Flor Mendez, Alejandro J. Nicola Candia, Brittany M. Salazar, Fernando M. Núñez, Marta Edwards, Tingting Qin, Rodrigo T. Cartaxo, Michael Niculcea, Carl Koschmann, Sriram Venneti, Montserrat Puigdelloses Vallcorba, Emon Nasajpour, Giulia Pericoli, Maria Vinci, Claudia L. Kleinman, Nada Jabado, James P. Chandler, Adam M. Sonabend, Michael DeCuypere, Dolores Hambardzumyan, Laura M. Prolo, Kelly B. Mahaney, Gerald A. Grant, Claudia Petritsch, Joshua D. Welch, Maureen A. Sartor, P R Lowenstein, María G. Castro

List of authors in order
Landing page: https://doi.org/10.1101/2023.06.13.544658

Publisher landing page
PDF URL: https://www.biorxiv.org/content/biorxiv/early/2023/06/13/2023.06.13.544658.full.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: green

Open access status per OpenAlex
OA URL: https://www.biorxiv.org/content/biorxiv/early/2023/06/13/2023.06.13.544658.full.pdf

Direct OA link when available
Concepts: Reprogramming, Epigenetics, Mutation, Gene, Immune system, Biology, Genetics, Cancer research, Genetic enhancement, Medicine, Bioinformatics

Top concepts (fields/topics) attached by OpenAlex
Cited by: 6

Total citation count in OpenAlex
Citations by year (recent): 2025: 3, 2024: 3

Per-year citation counts (last 5 years)
References (count): 94

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4380624299
doi	https://doi.org/10.1101/2023.06.13.544658
ids.doi	https://doi.org/10.1101/2023.06.13.544658
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/37398299
ids.openalex	https://openalex.org/W4380624299
fwci	2.25409382
type	preprint
title	H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T10129
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9976000189781189
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2716
topics[0].subfield.display_name	Genetics
topics[0].display_name	Glioma Diagnosis and Treatment
topics[1].id	https://openalex.org/T12996
topics[1].field.id	https://openalex.org/fields/13
topics[1].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[1].score	0.9922000169754028
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/1305
topics[1].subfield.display_name	Biotechnology
topics[1].display_name	Cancer Research and Treatments
topics[2].id	https://openalex.org/T10613
topics[2].field.id	https://openalex.org/fields/13
topics[2].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[2].score	0.9894999861717224
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/1311
topics[2].subfield.display_name	Genetics
topics[2].display_name	Virus-based gene therapy research
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C77255625
concepts[0].level	3
concepts[0].score	0.822601854801178
concepts[0].wikidata	https://www.wikidata.org/wiki/Q402093
concepts[0].display_name	Reprogramming
concepts[1].id	https://openalex.org/C41091548
concepts[1].level	3
concepts[1].score	0.785228967666626
concepts[1].wikidata	https://www.wikidata.org/wiki/Q26939
concepts[1].display_name	Epigenetics
concepts[2].id	https://openalex.org/C501734568
concepts[2].level	3
concepts[2].score	0.5323391556739807
concepts[2].wikidata	https://www.wikidata.org/wiki/Q42918
concepts[2].display_name	Mutation
concepts[3].id	https://openalex.org/C104317684
concepts[3].level	2
concepts[3].score	0.5228381752967834
concepts[3].wikidata	https://www.wikidata.org/wiki/Q7187
concepts[3].display_name	Gene
concepts[4].id	https://openalex.org/C8891405
concepts[4].level	2
concepts[4].score	0.4872778654098511
concepts[4].wikidata	https://www.wikidata.org/wiki/Q1059
concepts[4].display_name	Immune system
concepts[5].id	https://openalex.org/C86803240
concepts[5].level	0
concepts[5].score	0.45161229372024536
concepts[5].wikidata	https://www.wikidata.org/wiki/Q420
concepts[5].display_name	Biology
concepts[6].id	https://openalex.org/C54355233
concepts[6].level	1
concepts[6].score	0.4434368312358856
concepts[6].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[6].display_name	Genetics
concepts[7].id	https://openalex.org/C502942594
concepts[7].level	1
concepts[7].score	0.43841370940208435
concepts[7].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[7].display_name	Cancer research
concepts[8].id	https://openalex.org/C111599444
concepts[8].level	3
concepts[8].score	0.41572073101997375
concepts[8].wikidata	https://www.wikidata.org/wiki/Q213901
concepts[8].display_name	Genetic enhancement
concepts[9].id	https://openalex.org/C71924100
concepts[9].level	0
concepts[9].score	0.37467139959335327
concepts[9].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[9].display_name	Medicine
concepts[10].id	https://openalex.org/C60644358
concepts[10].level	1
concepts[10].score	0.34995222091674805
concepts[10].wikidata	https://www.wikidata.org/wiki/Q128570
concepts[10].display_name	Bioinformatics
keywords[0].id	https://openalex.org/keywords/reprogramming
keywords[0].score	0.822601854801178
keywords[0].display_name	Reprogramming
keywords[1].id	https://openalex.org/keywords/epigenetics
keywords[1].score	0.785228967666626
keywords[1].display_name	Epigenetics
keywords[2].id	https://openalex.org/keywords/mutation
keywords[2].score	0.5323391556739807
keywords[2].display_name	Mutation
keywords[3].id	https://openalex.org/keywords/gene
keywords[3].score	0.5228381752967834
keywords[3].display_name	Gene
keywords[4].id	https://openalex.org/keywords/immune-system
keywords[4].score	0.4872778654098511
keywords[4].display_name	Immune system
keywords[5].id	https://openalex.org/keywords/biology
keywords[5].score	0.45161229372024536
keywords[5].display_name	Biology
keywords[6].id	https://openalex.org/keywords/genetics
keywords[6].score	0.4434368312358856
keywords[6].display_name	Genetics
keywords[7].id	https://openalex.org/keywords/cancer-research
keywords[7].score	0.43841370940208435
keywords[7].display_name	Cancer research
keywords[8].id	https://openalex.org/keywords/genetic-enhancement
keywords[8].score	0.41572073101997375
keywords[8].display_name	Genetic enhancement
keywords[9].id	https://openalex.org/keywords/medicine
keywords[9].score	0.37467139959335327
keywords[9].display_name	Medicine
keywords[10].id	https://openalex.org/keywords/bioinformatics
keywords[10].score	0.34995222091674805
keywords[10].display_name	Bioinformatics
language	en
locations[0].id	doi:10.1101/2023.06.13.544658
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4306402567
locations[0].source.issn
locations[0].source.type	repository
locations[0].source.is_oa	False
locations[0].source.issn_l
locations[0].source.is_core	False
locations[0].source.is_in_doaj	False
locations[0].source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
locations[0].source.host_organization	https://openalex.org/I2750212522
locations[0].source.host_organization_name	Cold Spring Harbor Laboratory
locations[0].source.host_organization_lineage	https://openalex.org/I2750212522
locations[0].license	cc-by-nc-nd
locations[0].pdf_url	https://www.biorxiv.org/content/biorxiv/early/2023/06/13/2023.06.13.544658.full.pdf
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by-nc-nd
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1101/2023.06.13.544658
locations[1].id	pmid:37398299
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	bioRxiv : the preprint server for biology
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/37398299
locations[2].id	pmh:oai:pubmedcentral.nih.gov:10312611
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S2764455111
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	PubMed Central
locations[2].source.host_organization	https://openalex.org/I1299303238
locations[2].source.host_organization_name	National Institutes of Health
locations[2].source.host_organization_lineage	https://openalex.org/I1299303238
locations[2].license	cc-by-nc-nd
locations[2].pdf_url	https://pmc.ncbi.nlm.nih.gov/articles/PMC10312611/pdf/nihpp-2023.06.13.544658v2.pdf
locations[2].version	submittedVersion
locations[2].raw_type	Text
locations[2].license_id	https://openalex.org/licenses/cc-by-nc-nd
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name	bioRxiv
locations[2].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/10312611
indexed_in	crossref, pubmed
authorships[0].author.id	https://openalex.org/A5006240088
authorships[0].author.orcid	https://orcid.org/0000-0002-2824-4926
authorships[0].author.display_name	María Belén Garcia-Fabiani
authorships[0].countries	AR, US
authorships[0].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[0].affiliations[0].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[0].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[0].affiliations[1].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[0].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[0].affiliations[2].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[0].affiliations[3].institution_ids	https://openalex.org/I2801749607
authorships[0].affiliations[3].raw_affiliation_string	Leloir Institute Foundation, Buenos Aires, Argentina
authorships[0].institutions[0].id	https://openalex.org/I2801749607
authorships[0].institutions[0].ror	https://ror.org/0431v7h69
authorships[0].institutions[0].type	facility
authorships[0].institutions[0].lineage	https://openalex.org/I2801749607
authorships[0].institutions[0].country_code	AR
authorships[0].institutions[0].display_name	Fundación Instituto Leloir
authorships[0].institutions[1].id	https://openalex.org/I27837315
authorships[0].institutions[1].ror	https://ror.org/00jmfr291
authorships[0].institutions[1].type	education
authorships[0].institutions[1].lineage	https://openalex.org/I27837315
authorships[0].institutions[1].country_code	US
authorships[0].institutions[1].display_name	University of Michigan
authorships[0].author_position	first
authorships[0].raw_author_name	Maria B. Garcia-Fabiani
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Leloir Institute Foundation, Buenos Aires, Argentina, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[1].author.id	https://openalex.org/A5041684349
authorships[1].author.orcid	https://orcid.org/0000-0001-5964-0748
authorships[1].author.display_name	Santiago Haase
authorships[1].countries	US
authorships[1].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[1].affiliations[0].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[1].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[1].affiliations[1].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[1].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[1].affiliations[2].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[1].institutions[0].id	https://openalex.org/I27837315
authorships[1].institutions[0].ror	https://ror.org/00jmfr291
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I27837315
authorships[1].institutions[0].country_code	US
authorships[1].institutions[0].display_name	University of Michigan
authorships[1].author_position	middle
authorships[1].raw_author_name	Santiago Haase
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[2].author.id	https://openalex.org/A5037173799
authorships[2].author.orcid	https://orcid.org/0000-0002-9903-4192
authorships[2].author.display_name	Kaushik Banerjee
authorships[2].countries	US
authorships[2].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[2].affiliations[0].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[2].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[2].affiliations[1].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[2].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[2].affiliations[2].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[2].institutions[0].id	https://openalex.org/I27837315
authorships[2].institutions[0].ror	https://ror.org/00jmfr291
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I27837315
authorships[2].institutions[0].country_code	US
authorships[2].institutions[0].display_name	University of Michigan
authorships[2].author_position	middle
authorships[2].raw_author_name	Kaushik Banerjee
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[3].author.id	https://openalex.org/A5010843806
authorships[3].author.orcid	https://orcid.org/0000-0002-6681-9153
authorships[3].author.display_name	Ziwen Zhu
authorships[3].countries	US
authorships[3].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[3].affiliations[0].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[3].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[3].affiliations[1].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[3].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[3].affiliations[2].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[3].institutions[0].id	https://openalex.org/I27837315
authorships[3].institutions[0].ror	https://ror.org/00jmfr291
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I27837315
authorships[3].institutions[0].country_code	US
authorships[3].institutions[0].display_name	University of Michigan
authorships[3].author_position	middle
authorships[3].raw_author_name	Ziwen Zhu
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[4].author.id	https://openalex.org/A5019248923
authorships[4].author.orcid	https://orcid.org/0000-0001-8505-3854
authorships[4].author.display_name	Brandon L. McClellan
authorships[4].countries	US
authorships[4].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[4].affiliations[0].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[4].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[4].affiliations[1].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[4].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[4].affiliations[2].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[4].institutions[0].id	https://openalex.org/I27837315
authorships[4].institutions[0].ror	https://ror.org/00jmfr291
authorships[4].institutions[0].type	education
authorships[4].institutions[0].lineage	https://openalex.org/I27837315
authorships[4].institutions[0].country_code	US
authorships[4].institutions[0].display_name	University of Michigan
authorships[4].author_position	middle
authorships[4].raw_author_name	Brandon L. McClellan
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[5].author.id	https://openalex.org/A5048599379
authorships[5].author.orcid	https://orcid.org/0000-0001-6114-7776
authorships[5].author.display_name	Anzar Mujeeb
authorships[5].countries	US
authorships[5].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[5].affiliations[0].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[5].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[5].affiliations[1].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[5].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[5].affiliations[2].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[5].institutions[0].id	https://openalex.org/I27837315
authorships[5].institutions[0].ror	https://ror.org/00jmfr291
authorships[5].institutions[0].type	education
authorships[5].institutions[0].lineage	https://openalex.org/I27837315
authorships[5].institutions[0].country_code	US
authorships[5].institutions[0].display_name	University of Michigan
authorships[5].author_position	middle
authorships[5].raw_author_name	Anzar A. Mujeeb
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[6].author.id	https://openalex.org/A5013633141
authorships[6].author.orcid	https://orcid.org/0000-0002-4888-7347
authorships[6].author.display_name	Y Li
authorships[6].countries	US
authorships[6].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[6].affiliations[0].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[6].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[6].affiliations[1].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[6].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[6].affiliations[2].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[6].institutions[0].id	https://openalex.org/I27837315
authorships[6].institutions[0].ror	https://ror.org/00jmfr291
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I27837315
authorships[6].institutions[0].country_code	US
authorships[6].institutions[0].display_name	University of Michigan
authorships[6].author_position	middle
authorships[6].raw_author_name	Yingxiang Li
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[7].author.id	https://openalex.org/A5087138140
authorships[7].author.orcid	https://orcid.org/0000-0003-4022-7384
authorships[7].author.display_name	Claire E. Tronrud
authorships[7].author_position	middle
authorships[7].raw_author_name	Claire E. Tronrud
authorships[7].is_corresponding	False
authorships[8].author.id	https://openalex.org/A5010344742
authorships[8].author.orcid	https://orcid.org/0000-0003-4878-3211
authorships[8].author.display_name	María L. Varela
authorships[8].author_position	middle
authorships[8].raw_author_name	Maria L. Varela
authorships[8].is_corresponding	False
authorships[9].author.id	https://openalex.org/A5025362237
authorships[9].author.orcid	https://orcid.org/0000-0002-9587-5760
authorships[9].author.display_name	Molly E.J. West
authorships[9].author_position	middle
authorships[9].raw_author_name	Molly E.J. West
authorships[9].is_corresponding	False
authorships[10].author.id	https://openalex.org/A5090088063
authorships[10].author.orcid	https://orcid.org/0000-0002-6137-0780
authorships[10].author.display_name	Jin Yü
authorships[10].countries	CN, US
authorships[10].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[10].affiliations[0].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[10].affiliations[1].institution_ids	https://openalex.org/I37461747, https://openalex.org/I4210120234
authorships[10].affiliations[1].raw_affiliation_string	Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China
authorships[10].institutions[0].id	https://openalex.org/I37461747
authorships[10].institutions[0].ror	https://ror.org/033vjfk17
authorships[10].institutions[0].type	education
authorships[10].institutions[0].lineage	https://openalex.org/I37461747
authorships[10].institutions[0].country_code	CN
authorships[10].institutions[0].display_name	Wuhan University
authorships[10].institutions[1].id	https://openalex.org/I4210120234
authorships[10].institutions[1].ror	https://ror.org/01v5mqw79
authorships[10].institutions[1].type	healthcare
authorships[10].institutions[1].lineage	https://openalex.org/I4210120234
authorships[10].institutions[1].country_code	CN
authorships[10].institutions[1].display_name	Zhongnan Hospital of Wuhan University
authorships[10].institutions[2].id	https://openalex.org/I27837315
authorships[10].institutions[2].ror	https://ror.org/00jmfr291
authorships[10].institutions[2].type	education
authorships[10].institutions[2].lineage	https://openalex.org/I27837315
authorships[10].institutions[2].country_code	US
authorships[10].institutions[2].display_name	University of Michigan
authorships[10].author_position	middle
authorships[10].raw_author_name	Jin Yu
authorships[10].is_corresponding	False
authorships[10].raw_affiliation_strings	Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[11].author.id	https://openalex.org/A5069563793
authorships[11].author.orcid	https://orcid.org/0000-0002-3273-9905
authorships[11].author.display_name	Padma Kadiyala
authorships[11].countries	US
authorships[11].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[11].affiliations[0].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[11].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[11].affiliations[1].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[11].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[11].affiliations[2].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[11].institutions[0].id	https://openalex.org/I27837315
authorships[11].institutions[0].ror	https://ror.org/00jmfr291
authorships[11].institutions[0].type	education
authorships[11].institutions[0].lineage	https://openalex.org/I27837315
authorships[11].institutions[0].country_code	US
authorships[11].institutions[0].display_name	University of Michigan
authorships[11].author_position	middle
authorships[11].raw_author_name	Padma Kadiyala
authorships[11].is_corresponding	False
authorships[11].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[12].author.id	https://openalex.org/A5006525866
authorships[12].author.orcid	https://orcid.org/0000-0001-5600-296X
authorships[12].author.display_name	Ayman Taher
authorships[12].countries	US
authorships[12].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[12].affiliations[0].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[12].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[12].affiliations[1].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[12].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[12].affiliations[2].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[12].institutions[0].id	https://openalex.org/I27837315
authorships[12].institutions[0].ror	https://ror.org/00jmfr291
authorships[12].institutions[0].type	education
authorships[12].institutions[0].lineage	https://openalex.org/I27837315
authorships[12].institutions[0].country_code	US
authorships[12].institutions[0].display_name	University of Michigan
authorships[12].author_position	middle
authorships[12].raw_author_name	Ayman W. Taher
authorships[12].is_corresponding	False
authorships[12].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[13].author.id	https://openalex.org/A5014849279
authorships[13].author.orcid	https://orcid.org/0000-0002-4962-3642
authorships[13].author.display_name	Felipe J. Núñez
authorships[13].countries	US
authorships[13].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[13].affiliations[0].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[13].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[13].affiliations[1].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[13].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[13].affiliations[2].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[13].institutions[0].id	https://openalex.org/I27837315
authorships[13].institutions[0].ror	https://ror.org/00jmfr291
authorships[13].institutions[0].type	education
authorships[13].institutions[0].lineage	https://openalex.org/I27837315
authorships[13].institutions[0].country_code	US
authorships[13].institutions[0].display_name	University of Michigan
authorships[13].author_position	middle
authorships[13].raw_author_name	Felipe J. Núñez
authorships[13].is_corresponding	False
authorships[13].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[14].author.id	https://openalex.org/A5056702691
authorships[14].author.orcid	https://orcid.org/0000-0002-8018-7674
authorships[14].author.display_name	Mahmoud S. Alghamri
authorships[14].countries	US
authorships[14].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[14].affiliations[0].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[14].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[14].affiliations[1].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[14].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[14].affiliations[2].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[14].institutions[0].id	https://openalex.org/I27837315
authorships[14].institutions[0].ror	https://ror.org/00jmfr291
authorships[14].institutions[0].type	education
authorships[14].institutions[0].lineage	https://openalex.org/I27837315
authorships[14].institutions[0].country_code	US
authorships[14].institutions[0].display_name	University of Michigan
authorships[14].author_position	middle
authorships[14].raw_author_name	Mahmoud S. Alghamri
authorships[14].is_corresponding	False
authorships[14].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[15].author.id	https://openalex.org/A5012916366
authorships[15].author.orcid	https://orcid.org/0000-0002-3398-5753
authorships[15].author.display_name	Andrea Comba
authorships[15].countries	US
authorships[15].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[15].affiliations[0].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[15].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[15].affiliations[1].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[15].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[15].affiliations[2].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[15].institutions[0].id	https://openalex.org/I27837315
authorships[15].institutions[0].ror	https://ror.org/00jmfr291
authorships[15].institutions[0].type	education
authorships[15].institutions[0].lineage	https://openalex.org/I27837315
authorships[15].institutions[0].country_code	US
authorships[15].institutions[0].display_name	University of Michigan
authorships[15].author_position	middle
authorships[15].raw_author_name	Andrea Comba
authorships[15].is_corresponding	False
authorships[15].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[16].author.id	https://openalex.org/A5061075380
authorships[16].author.orcid
authorships[16].author.display_name	Flor Mendez
authorships[16].countries	US
authorships[16].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[16].affiliations[0].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[16].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[16].affiliations[1].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[16].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[16].affiliations[2].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[16].institutions[0].id	https://openalex.org/I27837315
authorships[16].institutions[0].ror	https://ror.org/00jmfr291
authorships[16].institutions[0].type	education
authorships[16].institutions[0].lineage	https://openalex.org/I27837315
authorships[16].institutions[0].country_code	US
authorships[16].institutions[0].display_name	University of Michigan
authorships[16].author_position	middle
authorships[16].raw_author_name	Flor M. Mendez
authorships[16].is_corresponding	False
authorships[16].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[17].author.id	https://openalex.org/A5039788148
authorships[17].author.orcid	https://orcid.org/0000-0002-0194-560X
authorships[17].author.display_name	Alejandro J. Nicola Candia
authorships[17].countries	US
authorships[17].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[17].affiliations[0].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[17].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[17].affiliations[1].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[17].institutions[0].id	https://openalex.org/I27837315
authorships[17].institutions[0].ror	https://ror.org/00jmfr291
authorships[17].institutions[0].type	education
authorships[17].institutions[0].lineage	https://openalex.org/I27837315
authorships[17].institutions[0].country_code	US
authorships[17].institutions[0].display_name	University of Michigan
authorships[17].author_position	middle
authorships[17].raw_author_name	Alejandro J. Nicola Candia
authorships[17].is_corresponding	False
authorships[17].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[18].author.id	https://openalex.org/A5012875471
authorships[18].author.orcid	https://orcid.org/0000-0003-4017-3048
authorships[18].author.display_name	Brittany M. Salazar
authorships[18].countries	US
authorships[18].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[18].affiliations[0].raw_affiliation_string	Cancer Biology Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA
authorships[18].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[18].affiliations[1].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[18].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[18].affiliations[2].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[18].institutions[0].id	https://openalex.org/I27837315
authorships[18].institutions[0].ror	https://ror.org/00jmfr291
authorships[18].institutions[0].type	education
authorships[18].institutions[0].lineage	https://openalex.org/I27837315
authorships[18].institutions[0].country_code	US
authorships[18].institutions[0].display_name	University of Michigan
authorships[18].author_position	middle
authorships[18].raw_author_name	Brittany Salazar
authorships[18].is_corresponding	False
authorships[18].raw_affiliation_strings	Cancer Biology Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA, Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[19].author.id	https://openalex.org/A5102457205
authorships[19].author.orcid
authorships[19].author.display_name	Fernando M. Núñez
authorships[19].countries	US
authorships[19].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[19].affiliations[0].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[19].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[19].affiliations[1].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[19].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[19].affiliations[2].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[19].institutions[0].id	https://openalex.org/I27837315
authorships[19].institutions[0].ror	https://ror.org/00jmfr291
authorships[19].institutions[0].type	education
authorships[19].institutions[0].lineage	https://openalex.org/I27837315
authorships[19].institutions[0].country_code	US
authorships[19].institutions[0].display_name	University of Michigan
authorships[19].author_position	middle
authorships[19].raw_author_name	Fernando M. Nunez
authorships[19].is_corresponding	False
authorships[19].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[20].author.id	https://openalex.org/A5033848594
authorships[20].author.orcid
authorships[20].author.display_name	Marta Edwards
authorships[20].countries	US
authorships[20].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[20].affiliations[0].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[20].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[20].affiliations[1].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[20].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[20].affiliations[2].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[20].institutions[0].id	https://openalex.org/I27837315
authorships[20].institutions[0].ror	https://ror.org/00jmfr291
authorships[20].institutions[0].type	education
authorships[20].institutions[0].lineage	https://openalex.org/I27837315
authorships[20].institutions[0].country_code	US
authorships[20].institutions[0].display_name	University of Michigan
authorships[20].author_position	middle
authorships[20].raw_author_name	Marta B. Edwards
authorships[20].is_corresponding	False
authorships[20].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[21].author.id	https://openalex.org/A5038760380
authorships[21].author.orcid	https://orcid.org/0000-0003-3810-7578
authorships[21].author.display_name	Tingting Qin
authorships[21].countries	US
authorships[21].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[21].affiliations[0].raw_affiliation_string	Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 4109, USA
authorships[21].institutions[0].id	https://openalex.org/I27837315
authorships[21].institutions[0].ror	https://ror.org/00jmfr291
authorships[21].institutions[0].type	education
authorships[21].institutions[0].lineage	https://openalex.org/I27837315
authorships[21].institutions[0].country_code	US
authorships[21].institutions[0].display_name	University of Michigan
authorships[21].author_position	middle
authorships[21].raw_author_name	Tingting Qin
authorships[21].is_corresponding	False
authorships[21].raw_affiliation_strings	Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 4109, USA
authorships[22].author.id	https://openalex.org/A5007194474
authorships[22].author.orcid	https://orcid.org/0009-0001-2011-5695
authorships[22].author.display_name	Rodrigo T. Cartaxo
authorships[22].author_position	middle
authorships[22].raw_author_name	Rodrigo T. Cartaxo
authorships[22].is_corresponding	False
authorships[23].author.id	https://openalex.org/A5065582996
authorships[23].author.orcid
authorships[23].author.display_name	Michael Niculcea
authorships[23].author_position	middle
authorships[23].raw_author_name	Michael Niculcea
authorships[23].is_corresponding	False
authorships[24].author.id	https://openalex.org/A5001293585
authorships[24].author.orcid	https://orcid.org/0000-0002-0825-7615
authorships[24].author.display_name	Carl Koschmann
authorships[24].countries	US
authorships[24].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[24].affiliations[0].raw_affiliation_string	Department of Pediatrics, Chad Carr Pediatric Brain Tumor Center, University of Michigan Medical School, MI 48109, USA
authorships[24].institutions[0].id	https://openalex.org/I27837315
authorships[24].institutions[0].ror	https://ror.org/00jmfr291
authorships[24].institutions[0].type	education
authorships[24].institutions[0].lineage	https://openalex.org/I27837315
authorships[24].institutions[0].country_code	US
authorships[24].institutions[0].display_name	University of Michigan
authorships[24].author_position	middle
authorships[24].raw_author_name	Carl Koschmann
authorships[24].is_corresponding	False
authorships[24].raw_affiliation_strings	Department of Pediatrics, Chad Carr Pediatric Brain Tumor Center, University of Michigan Medical School, MI 48109, USA
authorships[25].author.id	https://openalex.org/A5026066701
authorships[25].author.orcid	https://orcid.org/0000-0001-9764-0423
authorships[25].author.display_name	Sriram Venneti
authorships[25].author_position	middle
authorships[25].raw_author_name	Sriram Venneti
authorships[25].is_corresponding	False
authorships[26].author.id	https://openalex.org/A5053559975
authorships[26].author.orcid
authorships[26].author.display_name	Montserrat Puigdelloses Vallcorba
authorships[26].author_position	middle
authorships[26].raw_author_name	Montserrat Puigdelloses Vallcorba
authorships[26].is_corresponding	False
authorships[27].author.id	https://openalex.org/A5028811503
authorships[27].author.orcid
authorships[27].author.display_name	Emon Nasajpour
authorships[27].author_position	middle
authorships[27].raw_author_name	Emon Nasajpour
authorships[27].is_corresponding	False
authorships[28].author.id	https://openalex.org/A5062469583
authorships[28].author.orcid	https://orcid.org/0000-0002-1177-9545
authorships[28].author.display_name	Giulia Pericoli
authorships[28].author_position	middle
authorships[28].raw_author_name	Giulia Pericoli
authorships[28].is_corresponding	False
authorships[29].author.id	https://openalex.org/A5006865176
authorships[29].author.orcid	https://orcid.org/0000-0002-7952-6771
authorships[29].author.display_name	Maria Vinci
authorships[29].countries	US
authorships[29].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[29].affiliations[0].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[29].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[29].affiliations[1].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[29].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[29].affiliations[2].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[29].institutions[0].id	https://openalex.org/I27837315
authorships[29].institutions[0].ror	https://ror.org/00jmfr291
authorships[29].institutions[0].type	education
authorships[29].institutions[0].lineage	https://openalex.org/I27837315
authorships[29].institutions[0].country_code	US
authorships[29].institutions[0].display_name	University of Michigan
authorships[29].author_position	middle
authorships[29].raw_author_name	Maria Vinci
authorships[29].is_corresponding	True
authorships[29].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[30].author.id	https://openalex.org/A5033420524
authorships[30].author.orcid	https://orcid.org/0000-0002-5158-7126
authorships[30].author.display_name	Claudia L. Kleinman
authorships[30].author_position	middle
authorships[30].raw_author_name	Claudia L. Kleinman
authorships[30].is_corresponding	False
authorships[31].author.id	https://openalex.org/A5069822100
authorships[31].author.orcid	https://orcid.org/0000-0003-2485-3692
authorships[31].author.display_name	Nada Jabado
authorships[31].author_position	middle
authorships[31].raw_author_name	Nada Jabado
authorships[31].is_corresponding	False
authorships[32].author.id	https://openalex.org/A5108810235
authorships[32].author.orcid
authorships[32].author.display_name	James P. Chandler
authorships[32].author_position	middle
authorships[32].raw_author_name	James P. Chandler
authorships[32].is_corresponding	False
authorships[33].author.id	https://openalex.org/A5060408739
authorships[33].author.orcid	https://orcid.org/0000-0002-8347-1945
authorships[33].author.display_name	Adam M. Sonabend
authorships[33].author_position	middle
authorships[33].raw_author_name	Adam M. Sonabend
authorships[33].is_corresponding	False
authorships[34].author.id	https://openalex.org/A5057214759
authorships[34].author.orcid	https://orcid.org/0000-0002-4598-8644
authorships[34].author.display_name	Michael DeCuypere
authorships[34].author_position	middle
authorships[34].raw_author_name	Michael DeCuypere
authorships[34].is_corresponding	False
authorships[35].author.id	https://openalex.org/A5068940074
authorships[35].author.orcid	https://orcid.org/0000-0003-1975-4665
authorships[35].author.display_name	Dolores Hambardzumyan
authorships[35].author_position	middle
authorships[35].raw_author_name	Dolores Hambardzumyan
authorships[35].is_corresponding	False
authorships[36].author.id	https://openalex.org/A5019769558
authorships[36].author.orcid	https://orcid.org/0000-0001-7737-8675
authorships[36].author.display_name	Laura M. Prolo
authorships[36].author_position	middle
authorships[36].raw_author_name	Laura M. Prolo
authorships[36].is_corresponding	False
authorships[37].author.id	https://openalex.org/A5015720226
authorships[37].author.orcid
authorships[37].author.display_name	Kelly B. Mahaney
authorships[37].author_position	middle
authorships[37].raw_author_name	Kelly B. Mahaney
authorships[37].is_corresponding	False
authorships[38].author.id	https://openalex.org/A5012203120
authorships[38].author.orcid	https://orcid.org/0000-0002-2651-4603
authorships[38].author.display_name	Gerald A. Grant
authorships[38].author_position	middle
authorships[38].raw_author_name	Gerald A. Grant
authorships[38].is_corresponding	False
authorships[39].author.id	https://openalex.org/A5081200258
authorships[39].author.orcid	https://orcid.org/0000-0002-3442-4974
authorships[39].author.display_name	Claudia Petritsch
authorships[39].author_position	middle
authorships[39].raw_author_name	Claudia K Petritsch
authorships[39].is_corresponding	False
authorships[40].author.id	https://openalex.org/A5032755605
authorships[40].author.orcid	https://orcid.org/0000-0002-5869-2391
authorships[40].author.display_name	Joshua D. Welch
authorships[40].author_position	middle
authorships[40].raw_author_name	Joshua D. Welch
authorships[40].is_corresponding	False
authorships[41].author.id	https://openalex.org/A5028712728
authorships[41].author.orcid	https://orcid.org/0000-0001-6155-5702
authorships[41].author.display_name	Maureen A. Sartor
authorships[41].countries	US
authorships[41].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[41].affiliations[0].raw_affiliation_string	Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 4109, USA
authorships[41].institutions[0].id	https://openalex.org/I27837315
authorships[41].institutions[0].ror	https://ror.org/00jmfr291
authorships[41].institutions[0].type	education
authorships[41].institutions[0].lineage	https://openalex.org/I27837315
authorships[41].institutions[0].country_code	US
authorships[41].institutions[0].display_name	University of Michigan
authorships[41].author_position	middle
authorships[41].raw_author_name	Maureen A. Sartor
authorships[41].is_corresponding	False
authorships[41].raw_affiliation_strings	Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 4109, USA
authorships[42].author.id	https://openalex.org/A5109832590
authorships[42].author.orcid
authorships[42].author.display_name	P R Lowenstein
authorships[42].countries	US
authorships[42].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[42].affiliations[0].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[42].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[42].affiliations[1].raw_affiliation_string	Department of Bioengineering, University of Michigan, Ann Arbor, MI 4810, USA
authorships[42].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[42].affiliations[2].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[42].affiliations[3].institution_ids	https://openalex.org/I27837315
authorships[42].affiliations[3].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[42].institutions[0].id	https://openalex.org/I27837315
authorships[42].institutions[0].ror	https://ror.org/00jmfr291
authorships[42].institutions[0].type	education
authorships[42].institutions[0].lineage	https://openalex.org/I27837315
authorships[42].institutions[0].country_code	US
authorships[42].institutions[0].display_name	University of Michigan
authorships[42].author_position	middle
authorships[42].raw_author_name	Pedro R. Lowenstein
authorships[42].is_corresponding	False
authorships[42].raw_affiliation_strings	Department of Bioengineering, University of Michigan, Ann Arbor, MI 4810, USA, Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[43].author.id	https://openalex.org/A5082380342
authorships[43].author.orcid	https://orcid.org/0000-0003-2237-2756
authorships[43].author.display_name	María G. Castro
authorships[43].countries	US
authorships[43].affiliations[0].institution_ids	https://openalex.org/I27837315
authorships[43].affiliations[0].raw_affiliation_string	Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA
authorships[43].affiliations[1].institution_ids	https://openalex.org/I27837315
authorships[43].affiliations[1].raw_affiliation_string	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[43].affiliations[2].institution_ids	https://openalex.org/I27837315
authorships[43].affiliations[2].raw_affiliation_string	Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
authorships[43].institutions[0].id	https://openalex.org/I27837315
authorships[43].institutions[0].ror	https://ror.org/00jmfr291
authorships[43].institutions[0].type	education
authorships[43].institutions[0].lineage	https://openalex.org/I27837315
authorships[43].institutions[0].country_code	US
authorships[43].institutions[0].display_name	University of Michigan
authorships[43].author_position	last
authorships[43].raw_author_name	Maria G. Castro
authorships[43].is_corresponding	True
authorships[43].raw_affiliation_strings	Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 4809, USA, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://www.biorxiv.org/content/biorxiv/early/2023/06/13/2023.06.13.544658.full.pdf
open_access.oa_status	green
open_access.any_repository_has_fulltext	False
created_date	2023-06-15T00:00:00
display_name	H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas
has_fulltext	True
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10129
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9976000189781189
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2716
primary_topic.subfield.display_name	Genetics
primary_topic.display_name	Glioma Diagnosis and Treatment
related_works	https://openalex.org/W1631979401, https://openalex.org/W2395945797, https://openalex.org/W1497716427, https://openalex.org/W2129470469, https://openalex.org/W2368295610, https://openalex.org/W1543102035, https://openalex.org/W2946692299, https://openalex.org/W2979314934, https://openalex.org/W2146527561, https://openalex.org/W2770084104
cited_by_count	6
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	3
counts_by_year[1].year	2024
counts_by_year[1].cited_by_count	3
locations_count	3
best_oa_location.id	doi:10.1101/2023.06.13.544658
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4306402567
best_oa_location.source.issn
best_oa_location.source.type	repository
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
best_oa_location.source.host_organization	https://openalex.org/I2750212522
best_oa_location.source.host_organization_name	Cold Spring Harbor Laboratory
best_oa_location.source.host_organization_lineage	https://openalex.org/I2750212522
best_oa_location.license	cc-by-nc-nd
best_oa_location.pdf_url	https://www.biorxiv.org/content/biorxiv/early/2023/06/13/2023.06.13.544658.full.pdf
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by-nc-nd
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1101/2023.06.13.544658
primary_location.id	doi:10.1101/2023.06.13.544658
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4306402567
primary_location.source.issn
primary_location.source.type	repository
primary_location.source.is_oa	False
primary_location.source.issn_l
primary_location.source.is_core	False
primary_location.source.is_in_doaj	False
primary_location.source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
primary_location.source.host_organization	https://openalex.org/I2750212522
primary_location.source.host_organization_name	Cold Spring Harbor Laboratory
primary_location.source.host_organization_lineage	https://openalex.org/I2750212522
primary_location.license	cc-by-nc-nd
primary_location.pdf_url	https://www.biorxiv.org/content/biorxiv/early/2023/06/13/2023.06.13.544658.full.pdf
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by-nc-nd
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1101/2023.06.13.544658
publication_date	2023-06-13
publication_year	2023
referenced_works	https://openalex.org/W4211132876, https://openalex.org/W2915631817, https://openalex.org/W2417583025, https://openalex.org/W2991430679, https://openalex.org/W2751187578, https://openalex.org/W2145489645, https://openalex.org/W2158233796, https://openalex.org/W2127674449, https://openalex.org/W2792753642, https://openalex.org/W2608429091, https://openalex.org/W2062062519, https://openalex.org/W2006677561, https://openalex.org/W2170763061, https://openalex.org/W2803003012, https://openalex.org/W3110261743, https://openalex.org/W3206759263, https://openalex.org/W4297855383, https://openalex.org/W4302028395, https://openalex.org/W3203797662, https://openalex.org/W2569426717, https://openalex.org/W2783127976, https://openalex.org/W2138541072, https://openalex.org/W2949682695, https://openalex.org/W2066001238, https://openalex.org/W2098850271, https://openalex.org/W2116126240, https://openalex.org/W2082343822, https://openalex.org/W3018841379, https://openalex.org/W2292914130, https://openalex.org/W2887976258, https://openalex.org/W3033786641, https://openalex.org/W2109904759, https://openalex.org/W2151311897, https://openalex.org/W3084353531, https://openalex.org/W2509933851, https://openalex.org/W2975995592, https://openalex.org/W2888883177, https://openalex.org/W2607585298, https://openalex.org/W1995105508, https://openalex.org/W2147524392, https://openalex.org/W3176649308, https://openalex.org/W2074018647, https://openalex.org/W2167017590, https://openalex.org/W2802731336, https://openalex.org/W2145012483, https://openalex.org/W3090386083, https://openalex.org/W65867874, https://openalex.org/W3183862228, https://openalex.org/W2335809174, https://openalex.org/W3024126283, https://openalex.org/W2159675211, https://openalex.org/W2140489687, https://openalex.org/W2591531756, https://openalex.org/W2950183092, https://openalex.org/W2953562746, https://openalex.org/W2573339072, https://openalex.org/W2060279158, https://openalex.org/W2016964866, https://openalex.org/W2760038100, https://openalex.org/W1588685142, https://openalex.org/W2513757956, https://openalex.org/W2994525341, https://openalex.org/W2002353628, https://openalex.org/W3005258006, https://openalex.org/W2535359105, https://openalex.org/W2595863515, https://openalex.org/W4316661407, https://openalex.org/W2159659449, https://openalex.org/W2164189319, https://openalex.org/W4211177275, https://openalex.org/W2044661631, https://openalex.org/W1893799230, https://openalex.org/W4386243733, https://openalex.org/W2790035192, https://openalex.org/W4283311416, https://openalex.org/W2952481429, https://openalex.org/W2806530968, https://openalex.org/W3017023874, https://openalex.org/W2170551349, https://openalex.org/W2341539131, https://openalex.org/W2099199578, https://openalex.org/W2761133874, https://openalex.org/W2168131180, https://openalex.org/W2018363492, https://openalex.org/W3009317529, https://openalex.org/W2608984150, https://openalex.org/W4378212544, https://openalex.org/W4200328199, https://openalex.org/W2169456326, https://openalex.org/W2179438025, https://openalex.org/W2159707944, https://openalex.org/W2948312711, https://openalex.org/W2145801480, https://openalex.org/W2148977460
referenced_works_count	94
abstract_inverted_index.a	155
abstract_inverted_index.H3	5
abstract_inverted_index.OF	173
abstract_inverted_index.To	42
abstract_inverted_index.an	91
abstract_inverted_index.at	73, 205
abstract_inverted_index.in	39, 87, 90, 117, 147, 161, 184, 190, 210
abstract_inverted_index.of	9, 26, 29, 82, 97, 180, 199
abstract_inverted_index.to	36, 79, 108
abstract_inverted_index.we	45
abstract_inverted_index.50%	110
abstract_inverted_index.DHG	49, 53
abstract_inverted_index.G34	67
abstract_inverted_index.Our	62, 194
abstract_inverted_index.The	95
abstract_inverted_index.and	33, 55, 75, 106, 132, 168, 212
abstract_inverted_index.any	122
abstract_inverted_index.are	11
abstract_inverted_index.for	144, 158
abstract_inverted_index.the	24, 30, 34, 66, 80, 83, 118, 125, 178, 181, 186, 197
abstract_inverted_index.DHG.	41
abstract_inverted_index.This	21, 175
abstract_inverted_index.Upon	114
abstract_inverted_index.end,	44
abstract_inverted_index.gene	100
abstract_inverted_index.hold	141
abstract_inverted_index.lead	107
abstract_inverted_index.long	111
abstract_inverted_index.over	109
abstract_inverted_index.poor	19
abstract_inverted_index.role	25, 179
abstract_inverted_index.show	64
abstract_inverted_index.term	112
abstract_inverted_index.that	65, 138
abstract_inverted_index.this	43, 162
abstract_inverted_index.turn	88
abstract_inverted_index.with	18
abstract_inverted_index.(CNS)	16
abstract_inverted_index.9-15%	8
abstract_inverted_index.DHGs,	153
abstract_inverted_index.DHGs.	218
abstract_inverted_index.These	135
abstract_inverted_index.human	47
abstract_inverted_index.mouse	59
abstract_inverted_index.study	22, 176
abstract_inverted_index.tumor	93, 115, 187
abstract_inverted_index.which	86
abstract_inverted_index.young	169, 213
abstract_inverted_index.(AYA).	171
abstract_inverted_index.(DHG),	4
abstract_inverted_index.System	15
abstract_inverted_index.adults	170, 214
abstract_inverted_index.aiming	204
abstract_inverted_index.alters	69
abstract_inverted_index.cancer	164
abstract_inverted_index.cases,	10
abstract_inverted_index.glioma	3
abstract_inverted_index.immune	31, 188
abstract_inverted_index.median	104
abstract_inverted_index.models	60
abstract_inverted_index.mutant	152, 217
abstract_inverted_index.robust	129
abstract_inverted_index.tumors	17
abstract_inverted_index.Central	13
abstract_inverted_index.Diffuse	1
abstract_inverted_index.Nervous	14
abstract_inverted_index.diffuse	191
abstract_inverted_index.histone	70
abstract_inverted_index.leading	78
abstract_inverted_index.memory.	134
abstract_inverted_index.primary	51
abstract_inverted_index.results	89, 136
abstract_inverted_index.subtype	165
abstract_inverted_index.support	196
abstract_inverted_index.therapy	101
abstract_inverted_index.without	121
abstract_inverted_index.(GEMMs).	61
abstract_inverted_index.ABSTRACT	0
abstract_inverted_index.H3.3-G34	151, 182, 216
abstract_inverted_index.JAK/STAT	84
abstract_inverted_index.clinical	145
abstract_inverted_index.enhanced	207
abstract_inverted_index.enhancer	76
abstract_inverted_index.examines	23
abstract_inverted_index.findings	63, 195
abstract_inverted_index.gliomas.	193
abstract_inverted_index.immunity	131
abstract_inverted_index.improved	103
abstract_inverted_index.indicate	137
abstract_inverted_index.informed	202
abstract_inverted_index.marks’	71
abstract_inverted_index.medicine	201
abstract_inverted_index.mutation	68, 183
abstract_inverted_index.offering	154
abstract_inverted_index.outcomes	160, 209
abstract_inverted_index.pathway,	85
abstract_inverted_index.patients	149
abstract_inverted_index.promoter	74
abstract_inverted_index.regions,	77
abstract_inverted_index.response	35
abstract_inverted_index.strategy	157
abstract_inverted_index.treating	148
abstract_inverted_index.uncovers	177
abstract_inverted_index.utilized	46
abstract_inverted_index.STATEMENT	172
abstract_inverted_index.affecting	166
abstract_inverted_index.biopsies,	50
abstract_inverted_index.cultures,	54
abstract_inverted_index.exhibited	128
abstract_inverted_index.harboring	150, 215
abstract_inverted_index.improving	159, 206
abstract_inverted_index.long-term	126
abstract_inverted_index.potential	143
abstract_inverted_index.precision	200
abstract_inverted_index.promising	156
abstract_inverted_index.survival,	105
abstract_inverted_index.survivors	127
abstract_inverted_index.therapies	38, 140
abstract_inverted_index.G34-mutant	40, 48, 52, 58
abstract_inverted_index.activation	81
abstract_inverted_index.additional	123
abstract_inverted_index.aggressive	12
abstract_inverted_index.anti-tumor	130
abstract_inverted_index.deposition	72
abstract_inverted_index.engineered	57
abstract_inverted_index.epigenetic	27
abstract_inverted_index.hemisphere	120
abstract_inverted_index.prognosis.	20
abstract_inverted_index.survivors.	113
abstract_inverted_index.treatment,	124
abstract_inverted_index.G34-mutant,	6
abstract_inverted_index.adolescents	167, 211
abstract_inverted_index.challenging	163
abstract_inverted_index.genetically	56
abstract_inverted_index.hemispheric	2, 192
abstract_inverted_index.rechallenge	116
abstract_inverted_index.significant	142
abstract_inverted_index.therapeutic	208
abstract_inverted_index.translation	146
abstract_inverted_index.SIGNIFICANCE	174
abstract_inverted_index.representing	7
abstract_inverted_index.contralateral	119
abstract_inverted_index.immunological	133
abstract_inverted_index.reprogramming	28, 185
abstract_inverted_index.significantly	102
abstract_inverted_index.Ad-TK/Ad-Flt3L	98
abstract_inverted_index.implementation	96, 198
abstract_inverted_index.immune-mediated	37, 139
abstract_inverted_index.immunotherapies,	203
abstract_inverted_index.microenvironment	32, 189
abstract_inverted_index.immune-permissive	92
abstract_inverted_index.immunostimulatory	99
abstract_inverted_index.microenvironment.	94
cited_by_percentile_year.max	98
cited_by_percentile_year.min	96
corresponding_author_ids	https://openalex.org/A5082380342, https://openalex.org/A5006865176
countries_distinct_count	3
institutions_distinct_count	44
corresponding_institution_ids	https://openalex.org/I27837315
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.6899999976158142
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.87342163
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False