Haematological Studies on Induced Hyperlipidemia and its Amelioration Using Aged Garlic Extarct in Wistar Rats Article Swipe
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· 2020
· Open Access
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· DOI: https://doi.org/10.20546/ijcmas.2020.910.441
· OA: W3111677476
The effect of aged garlic extract on different haematological parameters was studied.The study included 72 Wistar albino rats were divided into 12 rats in each group.Group I served as normal control group.To group II high fat diet control was given as diet control.Rats in the group III were administered aged garlic extract at 200mg/kg bw.Group IV rats were administered aged garlic extract at 200mg/kg.bwwith high fat diet.Rats in group V were administered atorvastatin at15mg/kg.bwwith high fat diet.The group VI rats with aged garlic extract and atorvastatin at half dose (100mg and 7.5mg/kg respectively) with high fat diet.The duration of the study was for 56 days and the blood samples were collected at 42 nd and 56 th day of study for evaluation.The high fat diet induced hyperlipidemia altered haematological parameters; significant increase (P<0.05) in the platelet count and increased total leucocyte count.The aged garlic extract treatment showed improvements in the mean(±SE) values of total erythrocyte count, haemoglobin content and moderation of platelet count was seen, this suggested that the aged garlic extract could be used for improving the high fat diet induced haematological abnormalities.
