Haemophilus Protein F Orthologs of Pathogens Infecting the Airways: Exploiting Host Laminin at Heparin-Binding Sites for Maximal Adherence to Epithelial Cells Article Swipe
Yu‐Ching Su
,
Petra Halang
,
Christophe Fleury
,
Farshid Jalalvand
,
Matthias Mörgelin
,
Kristian Riesbeck
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1093/infdis/jix467
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1093/infdis/jix467
Haemophilus influenzae protein F (PF) is an important virulence factor interacting with laminin, an extracellular matrix protein ubiquitously expressed in the respiratory tract. Here we defined PF orthologs in Pseudomonas aeruginosa, Moraxella catarrhalis, and Staphylococcus aureus, bacteria that occasionally colonize and infect the human airways. Despite low sequence homology (48.2%-77.3% similarity), all orthologs (Paf, AfeA, and MntC) interacted with laminin. Interestingly, all proteins bound at the heparin-binding sites of laminin, including the globular domains, and also attached to laminin expressed on respiratory epithelial cells. Laminin is thus a highly important target for PF orthologs of the bacterial species examined.
Related Topics
Concepts
Moraxella catarrhalis
Laminin
Microbiology
Biology
Haemophilus influenzae
Virulence
Virulence factor
Extracellular matrix
Pseudomonas aeruginosa
Staphylococcus aureus
Bacteria
Gene
Cell biology
Genetics
Antibiotics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/infdis/jix467
- https://academic.oup.com/jid/article-pdf/216/10/1303/22204796/jix467.pdf
- OA Status
- bronze
- Cited By
- 12
- References
- 15
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2752775641
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2752775641Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/infdis/jix467Digital Object Identifier
- Title
-
Haemophilus Protein F Orthologs of Pathogens Infecting the Airways: Exploiting Host Laminin at Heparin-Binding Sites for Maximal Adherence to Epithelial CellsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-09-04Full publication date if available
- Authors
-
Yu‐Ching Su, Petra Halang, Christophe Fleury, Farshid Jalalvand, Matthias Mörgelin, Kristian RiesbeckList of authors in order
- Landing page
-
https://doi.org/10.1093/infdis/jix467Publisher landing page
- PDF URL
-
https://academic.oup.com/jid/article-pdf/216/10/1303/22204796/jix467.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/jid/article-pdf/216/10/1303/22204796/jix467.pdfDirect OA link when available
- Concepts
-
Moraxella catarrhalis, Laminin, Microbiology, Biology, Haemophilus influenzae, Virulence, Virulence factor, Extracellular matrix, Pseudomonas aeruginosa, Staphylococcus aureus, Bacteria, Gene, Cell biology, Genetics, AntibioticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 1, 2021: 1, 2020: 3, 2019: 4Per-year citation counts (last 5 years)
- References (count)
-
15Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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