Halide binding by myeloperoxidase is regulated by access channel dynamics and charge interactions Article Swipe
Urban Leitgeb
,
Radek Crha
,
Isabella Fegerl
,
Paul G. Furtmüller
,
Chris Oostenbrink
,
Vera Pfanzagl
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.ijbiomac.2025.148038
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.ijbiomac.2025.148038
The heme enzyme myeloperoxidase is a key player in the innate immune defense. It uses hydrogen peroxide to produce bactericidal hypohalous acids from (pseudo)halides, foremost chloride, and thiocyanate in the neutrophil phagosome. However, the available structural data on the halide-binding site, the marked pH dependence of halide oxidation, and the atypical pKa of an active-site histidine 261 fail to fully account for the mechanism of halide oxidation by myeloperoxidase. In the present study, crystal structures of myeloperoxidase-halide complexes show that halides can integrate into the hydrogen-bonding network formed by conserved water molecules, without directly interacting with the deprotonated histidine at both acidic and neutral pH. Molecular dynamics simulations reveal that protonation of histidine 261 decreases active site rigidity and increases the flexibility of arginine 405. Together with the terminal residues of the myeloperoxidase heavy and light chains, arginine 405 contributes to halide transport into the active site. Kinetic analyses and simulations further demonstrate that sodium ions play a critical role as charge shields, enabling halides to traverse the negatively charged access channel, which represents a key bottleneck for halide binding. Thus, halide access to the active site is governed by a complex interplay of electrostatic interactions involving both solvent ions and charged amino acid residues.
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Halide binding by myeloperoxidase is regulated by access channel dynamics and charge interactionsWork title
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2025-10-02Full publication date if available
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Urban Leitgeb, Radek Crha, Isabella Fegerl, Paul G. Furtmüller, Chris Oostenbrink, Vera PfanzaglList of authors in order
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https://doi.org/10.1016/j.ijbiomac.2025.148038Publisher landing page
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| referenced_works | https://openalex.org/W2108585076, https://openalex.org/W2004638361, https://openalex.org/W2059149560, https://openalex.org/W3003715287, https://openalex.org/W2140199154, https://openalex.org/W2317873538, https://openalex.org/W1578742674, https://openalex.org/W2036330691, https://openalex.org/W1997449896, https://openalex.org/W1768117386, https://openalex.org/W2031499823, https://openalex.org/W2041309279, https://openalex.org/W2160748613, https://openalex.org/W2045564220, https://openalex.org/W4296641386, https://openalex.org/W2107550339, https://openalex.org/W2018891565, https://openalex.org/W2959360304, https://openalex.org/W2037899297, https://openalex.org/W3015573046, https://openalex.org/W4413109578, https://openalex.org/W2046947907, https://openalex.org/W2091084150, https://openalex.org/W1974328198, https://openalex.org/W2946464205, https://openalex.org/W19950012, https://openalex.org/W2048185837, https://openalex.org/W2025694904, https://openalex.org/W1529673681, https://openalex.org/W2084814184, https://openalex.org/W2088767734, https://openalex.org/W2004032200, https://openalex.org/W2810348570, https://openalex.org/W2157878296, https://openalex.org/W4248872320, https://openalex.org/W2122994276, https://openalex.org/W2110808180, https://openalex.org/W2143660875, https://openalex.org/W2097493124, https://openalex.org/W2159211495, https://openalex.org/W2144081223, https://openalex.org/W2793715718, https://openalex.org/W2154197653, https://openalex.org/W1977194203, https://openalex.org/W1968583410, https://openalex.org/W1031578623, https://openalex.org/W3194348815, https://openalex.org/W2750226671, https://openalex.org/W2035266068, https://openalex.org/W2027154929, https://openalex.org/W2031418794, https://openalex.org/W2064388657, https://openalex.org/W2057477511, https://openalex.org/W2081693079, https://openalex.org/W2128572087, https://openalex.org/W2510475640, https://openalex.org/W2170711116, https://openalex.org/W1986176507, https://openalex.org/W365269203, https://openalex.org/W4385278832, https://openalex.org/W2468858310 |
| referenced_works_count | 61 |
| abstract_inverted_index.a | 5, 157, 174, 190 |
| abstract_inverted_index.In | 69 |
| abstract_inverted_index.It | 13 |
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| abstract_inverted_index.light | 135 |
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