HBx-induced upregulation of MAP1S drives hepatocellular carcinoma proliferation and migration via MAP1S/Smad/TGF-β1 loop Article Swipe
Yuanyue Guan
,
Jia Liu
,
Bin Sun
,
Kaikun Xu
,
Yonghong Zhang
,
Haijing Ben
,
Yingmei Feng
,
Mengcheng Liu
,
Shanshan Wang
,
Yuxue Gao
,
Zhongping Duan
,
Yan‐Jin Zhang
,
Dexi Chen
,
Yanjun Wang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.ijbiomac.2024.136327
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.ijbiomac.2024.136327
Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), has a significantly higher risk of recurrence. However, the exact mechanism by which HBV prompts HCC recurrence remains largely unknown. In this study liver microarray test revealed significant upregulation of microtubule associated protein 1S (MAP1S) in metastatic HCC compared to control. MAP1S knockdown suppressed growth of HCCLM3 cells in vitro and in vivo. Mechanistically, HBV-encoded X protein (HBx) upregulates MAP1S, which enhances microtubule (MT) acetylation by promoting the degradation of histone deacetylase 6 (HDAC6), and facilitates the nuclear translocation of Smad complex, and thereby enhancing downstream TGF-β signaling. Smad complex, in turn, increases MAP1S, establishing a feedback loop of MAP1S/Smad/TGF-β1. Finally, survival analysis of 150 HBV-associated HCC patients demonstrated both increased MAP1S and decreased HDAC6 were significantly associated with shorter relapse-free survival. Collectively, this study reveals a unique mechanism whereby HBx-induced upregulation of MAP1S drives HBV-related HCC proliferation and migration through the MAP1S/Smad/TGF-β1 feedback loop. TEASER: MAP1S is a key link between HBV infection and a higher risk of metastatic recurrence of HCC.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.ijbiomac.2024.136327
- OA Status
- hybrid
- Cited By
- 2
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403154413
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4403154413Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.ijbiomac.2024.136327Digital Object Identifier
- Title
-
HBx-induced upregulation of MAP1S drives hepatocellular carcinoma proliferation and migration via MAP1S/Smad/TGF-β1 loopWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-10-05Full publication date if available
- Authors
-
Yuanyue Guan, Jia Liu, Bin Sun, Kaikun Xu, Yonghong Zhang, Haijing Ben, Yingmei Feng, Mengcheng Liu, Shanshan Wang, Yuxue Gao, Zhongping Duan, Yan‐Jin Zhang, Dexi Chen, Yanjun WangList of authors in order
- Landing page
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https://doi.org/10.1016/j.ijbiomac.2024.136327Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.ijbiomac.2024.136327Direct OA link when available
- Concepts
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Downregulation and upregulation, SMAD, HBx, Hepatocellular carcinoma, Transforming growth factor, Cancer research, Chemistry, Loop (graph theory), Cell biology, Biology, Gene, Biochemistry, Transfection, Combinatorics, MathematicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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48Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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