Head Down Tilt 15° in Acute Ischemic Stroke with Poor Collaterals: A Randomized Preclinical Trial Article Swipe
Jacopo Mariani
,
Simone Beretta
,
Susanna Diamanti
,
Alessandro Versace
,
Beatrice Martini
,
Martina Viganò
,
Laura Castiglioni
,
Luigi Sironi
,
Davide Carone
,
Elisa Cuccione
,
L Monza
,
Carlo Giussani
,
Carlo Ferrarese
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.neuroscience.2023.05.011
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.neuroscience.2023.05.011
Cerebral collaterals are recruited after arterial occlusion with a protective effect on tissue outcome in acute ischemic stroke. Head down tilt 15° (HDT15) is a simple, low cost and accessible procedure that could be applied as an emergency treatment, before recanalization therapies, with the aim to increase cerebral collateral flow. Spontaneously hypertensive rats have been shown to display anatomical differences in morphology and function of cerebral collaterals, compared to other rat strains, resulting in an overall poor collateral circulation. We investigate the efficacy and safety of HDT15 in spontaneously hypertensive (SHR) rats, which were considered as an animal stroke model with poor collaterals. Cerebral ischemia was induced by 90 minute endovascular occlusion of the middle cerebral artery (MCA). SHR rats were randomized to HDT15 or flat position (n = 19). HDT15 was applied 30 minutes after occlusion and lasted 60 minutes, until reperfusion. HDT15 application increased cerebral perfusion (+16.6% versus +6.1%; p = 0.0040) and resulted in a small reduction of infarct size (83.6 versus 107.1 mm3; - 21.89%; p = 0.0272), but it was not associated with early neurological improvement, compared to flat position. Our study suggests that the response to HDT15 during MCA occlusion is dependent on baseline collaterals. Nonetheless, HDT15 promoted a mild improvement of cerebral hemodynamics even in subjects with poor collaterals, without safety concerns.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.neuroscience.2023.05.011
- http://www.ibroneuroscience.org/article/S0306452223002221/pdf
- OA Status
- hybrid
- Cited By
- 6
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4377086810
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4377086810Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.neuroscience.2023.05.011Digital Object Identifier
- Title
-
Head Down Tilt 15° in Acute Ischemic Stroke with Poor Collaterals: A Randomized Preclinical TrialWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-05-19Full publication date if available
- Authors
-
Jacopo Mariani, Simone Beretta, Susanna Diamanti, Alessandro Versace, Beatrice Martini, Martina Viganò, Laura Castiglioni, Luigi Sironi, Davide Carone, Elisa Cuccione, L Monza, Carlo Giussani, Carlo FerrareseList of authors in order
- Landing page
-
https://doi.org/10.1016/j.neuroscience.2023.05.011Publisher landing page
- PDF URL
-
https://www.ibroneuroscience.org/article/S0306452223002221/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.ibroneuroscience.org/article/S0306452223002221/pdfDirect OA link when available
- Concepts
-
Medicine, Occlusion, Collateral circulation, Stroke (engine), Middle cerebral artery, Ischemia, Head-Down Tilt, Anesthesia, Cerebral perfusion pressure, Cardiology, Perfusion, Internal medicine, Cerebral blood flow, Blood pressure, Mechanical engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
32Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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