Head-to-Head in Heart Failure: Comparative Insights on Empagliflozin and Dapagliflozin Article Swipe
Dragoș Cozma
,
Cristina Văcărescu
,
Claudiu Stoicescu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines13102422
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines13102422
Heart failure (HF) remains a leading cause of morbidity and mortality globally, with increasing prevalence driven by aging populations and comorbidities such as diabetes mellitus. Recent advances have highlighted sodium-glucose cotransporter-2 (SGLT2) inhibitors, particularly empagliflozin and dapagliflozin, as effective agents in HF management across a broad spectrum of ejection fractions. Initially developed for glycemic control in type 2 diabetes, both drugs have demonstrated significant cardiovascular benefits, including reductions in HF hospitalizations and improvements in symptoms and quality of life. Their mechanisms extend beyond glucose lowering, involving natriuresis, osmotic diuresis, improved myocardial energetics, reduced sympathetic activation, and anti-inflammatory effects. While empagliflozin and dapagliflozin share a core renal mechanism via selective SGLT2 inhibition, subtle differences in pharmacokinetics, potency, and tissue selectivity may influence their clinical profiles. Emerging evidence suggests empagliflozin may confer stronger benefits in heart failure with reduced ejection fraction (HFrEF), while dapagliflozin could offer enhanced efficacy in heart failure with preserved ejection franction (HFpEF), although head-to-head comparisons are lacking. This review synthesizes current evidence comparing the mechanisms of action and clinical performance of empagliflozin and dapagliflozin in HF, providing insight into agent selection and future directions in therapy personalization.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomedicines13102422
- https://www.mdpi.com/2227-9059/13/10/2422/pdf?version=1759488317
- OA Status
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4414782138Canonical identifier for this work in OpenAlex
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https://doi.org/10.3390/biomedicines13102422Digital Object Identifier
- Title
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Head-to-Head in Heart Failure: Comparative Insights on Empagliflozin and DapagliflozinWork title
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reviewOpenAlex work type
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enPrimary language
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2025Year of publication
- Publication date
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2025-10-03Full publication date if available
- Authors
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Dragoș Cozma, Cristina Văcărescu, Claudiu StoicescuList of authors in order
- Landing page
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https://doi.org/10.3390/biomedicines13102422Publisher landing page
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https://www.mdpi.com/2227-9059/13/10/2422/pdf?version=1759488317Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2227-9059/13/10/2422/pdf?version=1759488317Direct OA link when available
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0Total citation count in OpenAlex
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71Number of works referenced by this work
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| abstract_inverted_index.remains | 3 |
| abstract_inverted_index.therapy | 187 |
| abstract_inverted_index.(HFpEF), | 153 |
| abstract_inverted_index.(HFrEF), | 139 |
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| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5013745920 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 3 |
| corresponding_institution_ids | https://openalex.org/I4210088791, https://openalex.org/I4210137719 |
| citation_normalized_percentile.value | 0.5814672 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |