Health-Related Quality of Life and Social Outcomes in Adolescents and Young Adult Survivors of Childhood Cancer: A Single-Center Case–Control Study from Crete, Greece Article Swipe
Ioannis Kyriakidis
,
Iordanis Pelagiadis
,
Nikolaos Katzilakis
,
Margarita Pesmatzoglou
,
Maria Stratigaki
,
Stylianos Megremis
,
Eftichia Stiakaki
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/reports8040207
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/reports8040207
Background: Recent advances in childhood cancer treatment and increased survival rates have led to a growing number of adolescents and young adults (AYAs) who are survivors of childhood cancer (CCSs). This study aimed to examine health status, health-related quality of life (HRQoL), and social outcomes in AYA CCSs. Methods: Sixty-two AYAs who were CCSs (treated within the same tertiary Pediatric Hematology–Oncology Department in Crete, Greece) were enrolled in the study. Self-reported HRQoL was assessed using the Short-Form Health Survey (SF-36). Sixty-five never-ill peers constituted the control group. Results: CCSs reach adolescence and young adulthood without significant deviations in HRQoL from their healthy peers. The presence and severity of late effects were significantly correlated with lower scores in physical health. The cancer type seems to play a pivotal role: Langerhans cell histiocytosis survivors displayed significantly lower scores in mental health, and brain tumor survivors scored substantially lower scores in physical functioning. Acute lymphoblastic leukemia survivors reported the highest scores in mental health. Age at diagnosis of neoplasia was negatively correlated with physical functioning. No significant sex differences were identified. Adherence to multiple healthy lifestyle behaviors (regular exercise, abstaining from alcohol consumption and smoking, and using sun protection) and active employment were correlated with significantly higher scores in mental health. Conclusions: Appropriate therapy and regular follow-up after treatment have led to improved clinical and social outcomes, as assessed by CCSs. More efforts are needed to increase awareness of avoiding harmful behaviors that raise the risk of late effects in this specific group.
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Metadata
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- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/reports8040207
- https://www.mdpi.com/2571-841X/8/4/207/pdf?version=1760703234
- OA Status
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- 42
- OpenAlex ID
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All OpenAlex metadata
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https://doi.org/10.3390/reports8040207Digital Object Identifier
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Health-Related Quality of Life and Social Outcomes in Adolescents and Young Adult Survivors of Childhood Cancer: A Single-Center Case–Control Study from Crete, GreeceWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-10-17Full publication date if available
- Authors
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Ioannis Kyriakidis, Iordanis Pelagiadis, Nikolaos Katzilakis, Margarita Pesmatzoglou, Maria Stratigaki, Stylianos Megremis, Eftichia StiakakiList of authors in order
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https://doi.org/10.3390/reports8040207Publisher landing page
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https://www.mdpi.com/2571-841X/8/4/207/pdf?version=1760703234Direct link to full text PDF
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2571-841X/8/4/207/pdf?version=1760703234Direct OA link when available
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0Total citation count in OpenAlex
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| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Reports |
| primary_location.landing_page_url | https://doi.org/10.3390/reports8040207 |
| publication_date | 2025-10-17 |
| publication_year | 2025 |
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