Healthy lifestyle linked to innate immunity and lipoprotein metabolism: a cross-sectional comparison using untargeted proteomics Article Swipe
David C. Nieman
,
Camila A. Sakaguchi
,
Matteo Pelleigrini
,
Michael J. Thompson
,
Susan Sumner
,
Qibin Zhang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-023-44068-9
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-023-44068-9
This study used untargeted proteomics to compare blood proteomic profiles in two groups of adults that differed widely in lifestyle habits. A total of 52 subjects in the lifestyle group (LIFE) (28 males, 24 females) and 52 in the control group (CON) (27 males, 25 females) participated in this cross-sectional study. Age, education level, marital status, and height did not differ significantly between LIFE and CON groups. The LIFE and CON groups differed markedly in body composition, physical activity patterns, dietary intake patterns, disease risk factor prevalence, blood measures of inflammation, triglycerides, HDL-cholesterol, glucose, and insulin, weight-adjusted leg/back and handgrip strength, and mood states. The proteomics analysis showed strong group differences for 39 of 725 proteins identified in dried blood spot samples. Of these, 18 were downregulated in the LIFE group and collectively indicated a lower innate immune activation signature. A total of 21 proteins were upregulated in the LIFE group and supported greater lipoprotein metabolism and HDL remodeling. Lifestyle-related habits and biomarkers were probed and the variance (> 50%) in proteomic profiles was best explained by group contrasts in indicators of adiposity. This cross-sectional study established that a relatively small number of proteins are associated with good lifestyle habits.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-023-44068-9
- https://www.nature.com/articles/s41598-023-44068-9.pdf
- OA Status
- gold
- Cited By
- 8
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387330309
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387330309Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41598-023-44068-9Digital Object Identifier
- Title
-
Healthy lifestyle linked to innate immunity and lipoprotein metabolism: a cross-sectional comparison using untargeted proteomicsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-10-04Full publication date if available
- Authors
-
David C. Nieman, Camila A. Sakaguchi, Matteo Pelleigrini, Michael J. Thompson, Susan Sumner, Qibin ZhangList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-023-44068-9Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41598-023-44068-9.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41598-023-44068-9.pdfDirect OA link when available
- Concepts
-
Innate immune system, Immunity, Cross-sectional study, Proteomics, Lipid metabolism, Computational biology, Immunology, Biology, Medicine, Bioinformatics, Biochemistry, Immune system, Pathology, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 3Per-year citation counts (last 5 years)
- References (count)
-
56Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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