Heart failure biomarkers in revascularized patients with stable coronary heart disease as clinical outcome predictors Article Swipe
Ivica Bošnjak
,
Dražen Bedeković
,
Kristina Selthofer-Relatić
,
Hrvoje Roguljić
,
Ivica Mihaljević
,
Darko Dukić
,
Ines Bilić-Čurčić
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fcvm.2024.1458120
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fcvm.2024.1458120
Introduction The aim of this study was to investigate serum levels of galectin-3 (Gal-3) and N-terminal pro-brain Natriuretic Peptide (NT-proBNP) in patients with stable obstructive coronary artery disease, as well as their potential to predict clinical outcomes. Methods This was a single-center cross-sectional cohort study. 168 patients were divided into three groups: percutaneous coronary intervention (PCI) group (N 64), coronary artery bypass graft surgery (CABG) group (N 57), and group with no coronary stenosis (N 47). Gal-3 and NT-proBNP levels were measured and the Syntax score (Ss) was calculated. Results The mean value of Gal-3 was 19.98 ng/ml and 9.51 ng/ml ( p < 0.001) in the study group and control group, respectively. Highest value of Gal-3 was found in the group of subjects with three-vessel disease ( p < 0.001). The mean value of NT-proBNP in the study group was 401.3 pg/ml, and in the control group 100.3 pg/ml ( p = 0.159). The highest value of NT-proBNP was found in the group of subjects with three-vessel disease ( p = 0.021). There was a statistically significant association between Gal-3, NT-proBNP and occurrence of adverse cardiovascular event ( p = 0.0018; p = 0.0019). Conclusion Gal-3 and NT-proBNP could be used as an additional tool for diagnosis and severity assessment of stable obstructive coronary artery disease. Furthermore, it could help identify high-risk patients who could experience major adverse cardiovascular events.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fcvm.2024.1458120
- OA Status
- gold
- Cited By
- 1
- References
- 28
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4402451773Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fcvm.2024.1458120Digital Object Identifier
- Title
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Heart failure biomarkers in revascularized patients with stable coronary heart disease as clinical outcome predictorsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-09-11Full publication date if available
- Authors
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Ivica Bošnjak, Dražen Bedeković, Kristina Selthofer-Relatić, Hrvoje Roguljić, Ivica Mihaljević, Darko Dukić, Ines Bilić-ČurčićList of authors in order
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https://doi.org/10.3389/fcvm.2024.1458120Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.3389/fcvm.2024.1458120Direct OA link when available
- Concepts
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Medicine, Internal medicine, Cardiology, Percutaneous coronary intervention, Coronary artery disease, Conventional PCI, Heart failure, Cohort, Artery, Natriuretic peptide, Myocardial infarctionTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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