Heart failure patients' perspectives on treatment outcomes and unmet medical needs: A qualitative preference study Article Swipe
Alice Vanneste
,
Liese Barbier
,
R Missotten
,
Thomas Desmet
,
Walter Droogné
,
Sissel Michelsen
,
Peter Sinnaeve
,
Tom Adriaenssens
,
Isabelle Huys
,
Rosanne Janssens
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/ehf2.14891
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/ehf2.14891
Aims Decision‐makers still predominantly focus on the perspective of non‐patient stakeholders, which may deviate from the unique perspective of heart failure (HF) patients. To enhance patient‐centred decision‐making, there is a need for more patient‐based evidence derived directly from the patients themselves. Hence, this study aimed to understand (i) HF patients' unmet medical needs and preferred treatment outcomes; (ii) patients' risk tolerance; and (iii) their information needs, uncertainties and satisfaction towards HF treatment. Methods This qualitative patient preference study consisted of a literature review with a systematic search strategy and semi‐structured interviews with HF patients, analysed using the framework method. During the interviews, patients were asked to rank a predefined list of disease and treatment‐related characteristics informed by the literature review and were able to spontaneously raise additional characteristics. Results The study included 14 Belgian HF patients (age range: 58–79, mean age: 72). (i) Regarding their unmet medical needs, HF patients reported that the most important unmet medical needs were shortness of breath and fatigue, as they negatively impact their quality of life (QoL) and independence. In the ranking exercise, patients prioritized improvements in QoL over improvements in life expectancy, whereby the following characteristics received the highest cumulative score: (1) independence, (2) shortness of breath, (3) impaired renal function, (4) survival, (5) fatigue, (6) risk of hospitalization and (7) communication with and between physicians. Patients most often spontaneously raise characteristics related to the general care process. Mechanism of action, route of administration, dose frequency and weight fluctuations scored among the least important characteristics. (ii) Regarding patients' risk tolerance towards HF treatment, some of the patients expressed zero tolerance for side effects, as they had not yet experienced any discomfort caused by the treatment or disease. (iii) Regarding their information needs, patients voiced their desire to receive practical and comprehensible advice orally from their physician because they highly value individualized treatment decision‐making. Patients also expressed uncertainties regarding whether the experienced effects were due to their treatment, disease, ageing or other comorbidities. Conclusions This study shows that, besides increasing life expectancy, HF patients prioritize improvements in symptoms and side effects reducing their QoL and independence, such as shortness of breath and fatigue. The patient‐relevant characteristics identified in this study, from the perspective of HF patients themselves, may be useful to inform clinical trial endpoint selection and guide downstream drug development, evaluation and clinical decision‐making towards addressing the unmet medical needs and treatment outcomes of importance to HF patients.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/ehf2.14891
- OA Status
- gold
- Cited By
- 1
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399498093
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4399498093Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/ehf2.14891Digital Object Identifier
- Title
-
Heart failure patients' perspectives on treatment outcomes and unmet medical needs: A qualitative preference studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-06-10Full publication date if available
- Authors
-
Alice Vanneste, Liese Barbier, R Missotten, Thomas Desmet, Walter Droogné, Sissel Michelsen, Peter Sinnaeve, Tom Adriaenssens, Isabelle Huys, Rosanne JanssensList of authors in order
- Landing page
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https://doi.org/10.1002/ehf2.14891Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1002/ehf2.14891Direct OA link when available
- Concepts
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Medicine, Quality of life (healthcare), Life expectancy, Heart failure, Qualitative research, Physical therapy, Family medicine, Intensive care medicine, Internal medicine, Nursing, Population, Social science, Environmental health, SociologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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24Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.aimed | 45 |
| abstract_inverted_index.among | 248 |
| abstract_inverted_index.asked | 105 |
| abstract_inverted_index.focus | 5 |
| abstract_inverted_index.guide | 384 |
| abstract_inverted_index.heart | 20 |
| abstract_inverted_index.least | 250 |
| abstract_inverted_index.needs | 53, 158, 397 |
| abstract_inverted_index.often | 226 |
| abstract_inverted_index.other | 328 |
| abstract_inverted_index.raise | 126, 228 |
| abstract_inverted_index.renal | 207 |
| abstract_inverted_index.route | 239 |
| abstract_inverted_index.shows | 333 |
| abstract_inverted_index.still | 3 |
| abstract_inverted_index.study | 44, 78, 131, 332 |
| abstract_inverted_index.that, | 334 |
| abstract_inverted_index.their | 64, 145, 169, 287, 292, 302, 323, 349 |
| abstract_inverted_index.there | 28 |
| abstract_inverted_index.trial | 380 |
| abstract_inverted_index.unmet | 51, 146, 156, 395 |
| abstract_inverted_index.using | 96 |
| abstract_inverted_index.value | 307 |
| abstract_inverted_index.which | 12 |
| abstract_inverted_index.During | 100 |
| abstract_inverted_index.Hence, | 42 |
| abstract_inverted_index.advice | 299 |
| abstract_inverted_index.ageing | 326 |
| abstract_inverted_index.breath | 162, 357 |
| abstract_inverted_index.caused | 279 |
| abstract_inverted_index.desire | 293 |
| abstract_inverted_index.highly | 306 |
| abstract_inverted_index.impact | 168 |
| abstract_inverted_index.inform | 378 |
| abstract_inverted_index.needs, | 66, 148, 289 |
| abstract_inverted_index.orally | 300 |
| abstract_inverted_index.range: | 138 |
| abstract_inverted_index.review | 83, 120 |
| abstract_inverted_index.score: | 198 |
| abstract_inverted_index.scored | 247 |
| abstract_inverted_index.search | 87 |
| abstract_inverted_index.study, | 366 |
| abstract_inverted_index.unique | 17 |
| abstract_inverted_index.useful | 376 |
| abstract_inverted_index.voiced | 291 |
| abstract_inverted_index.weight | 245 |
| abstract_inverted_index.Belgian | 134 |
| abstract_inverted_index.Methods | 73 |
| abstract_inverted_index.Results | 129 |
| abstract_inverted_index.action, | 238 |
| abstract_inverted_index.because | 304 |
| abstract_inverted_index.besides | 335 |
| abstract_inverted_index.between | 222 |
| abstract_inverted_index.breath, | 204 |
| abstract_inverted_index.derived | 36 |
| abstract_inverted_index.deviate | 14 |
| abstract_inverted_index.disease | 112 |
| abstract_inverted_index.effects | 319, 347 |
| abstract_inverted_index.enhance | 25 |
| abstract_inverted_index.failure | 21 |
| abstract_inverted_index.general | 233 |
| abstract_inverted_index.highest | 196 |
| abstract_inverted_index.medical | 52, 147, 157, 396 |
| abstract_inverted_index.method. | 99 |
| abstract_inverted_index.patient | 76 |
| abstract_inverted_index.quality | 170 |
| abstract_inverted_index.ranking | 178 |
| abstract_inverted_index.receive | 295 |
| abstract_inverted_index.related | 230 |
| abstract_inverted_index.towards | 70, 258, 392 |
| abstract_inverted_index.whereby | 190 |
| abstract_inverted_index.whether | 316 |
| abstract_inverted_index.58–79, | 139 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Patients | 224, 311 |
| abstract_inverted_index.analysed | 95 |
| abstract_inverted_index.clinical | 379, 390 |
| abstract_inverted_index.directly | 37 |
| abstract_inverted_index.disease, | 325 |
| abstract_inverted_index.disease. | 284 |
| abstract_inverted_index.effects, | 270 |
| abstract_inverted_index.endpoint | 381 |
| abstract_inverted_index.evidence | 35 |
| abstract_inverted_index.fatigue, | 164, 212 |
| abstract_inverted_index.fatigue. | 359 |
| abstract_inverted_index.impaired | 206 |
| abstract_inverted_index.included | 132 |
| abstract_inverted_index.informed | 116 |
| abstract_inverted_index.outcomes | 400 |
| abstract_inverted_index.patients | 40, 103, 136, 150, 180, 264, 290, 340, 372 |
| abstract_inverted_index.process. | 235 |
| abstract_inverted_index.received | 194 |
| abstract_inverted_index.reducing | 348 |
| abstract_inverted_index.reported | 151 |
| abstract_inverted_index.strategy | 88 |
| abstract_inverted_index.symptoms | 344 |
| abstract_inverted_index.Mechanism | 236 |
| abstract_inverted_index.Regarding | 144, 254, 286 |
| abstract_inverted_index.consisted | 79 |
| abstract_inverted_index.exercise, | 179 |
| abstract_inverted_index.expressed | 265, 313 |
| abstract_inverted_index.following | 192 |
| abstract_inverted_index.framework | 98 |
| abstract_inverted_index.frequency | 243 |
| abstract_inverted_index.function, | 208 |
| abstract_inverted_index.important | 155, 251 |
| abstract_inverted_index.outcomes; | 57 |
| abstract_inverted_index.patients' | 50, 59, 255 |
| abstract_inverted_index.patients, | 94 |
| abstract_inverted_index.patients. | 23, 405 |
| abstract_inverted_index.physician | 303 |
| abstract_inverted_index.practical | 296 |
| abstract_inverted_index.preferred | 55 |
| abstract_inverted_index.regarding | 315 |
| abstract_inverted_index.selection | 382 |
| abstract_inverted_index.shortness | 160, 202, 355 |
| abstract_inverted_index.survival, | 210 |
| abstract_inverted_index.tolerance | 257, 267 |
| abstract_inverted_index.treatment | 56, 282, 309, 399 |
| abstract_inverted_index.additional | 127 |
| abstract_inverted_index.addressing | 393 |
| abstract_inverted_index.cumulative | 197 |
| abstract_inverted_index.discomfort | 278 |
| abstract_inverted_index.downstream | 385 |
| abstract_inverted_index.evaluation | 388 |
| abstract_inverted_index.identified | 363 |
| abstract_inverted_index.importance | 402 |
| abstract_inverted_index.increasing | 336 |
| abstract_inverted_index.interviews | 91 |
| abstract_inverted_index.literature | 82, 119 |
| abstract_inverted_index.negatively | 167 |
| abstract_inverted_index.predefined | 109 |
| abstract_inverted_index.preference | 77 |
| abstract_inverted_index.prioritize | 341 |
| abstract_inverted_index.systematic | 86 |
| abstract_inverted_index.tolerance; | 61 |
| abstract_inverted_index.treatment, | 260, 324 |
| abstract_inverted_index.treatment. | 72 |
| abstract_inverted_index.understand | 47 |
| abstract_inverted_index.Conclusions | 330 |
| abstract_inverted_index.expectancy, | 189, 338 |
| abstract_inverted_index.experienced | 276, 318 |
| abstract_inverted_index.information | 65, 288 |
| abstract_inverted_index.interviews, | 102 |
| abstract_inverted_index.perspective | 8, 18, 369 |
| abstract_inverted_index.physicians. | 223 |
| abstract_inverted_index.prioritized | 181 |
| abstract_inverted_index.qualitative | 75 |
| abstract_inverted_index.themselves, | 373 |
| abstract_inverted_index.themselves. | 41 |
| abstract_inverted_index.development, | 387 |
| abstract_inverted_index.fluctuations | 246 |
| abstract_inverted_index.improvements | 182, 186, 342 |
| abstract_inverted_index.satisfaction | 69 |
| abstract_inverted_index.communication | 219 |
| abstract_inverted_index.independence, | 200, 352 |
| abstract_inverted_index.independence. | 175 |
| abstract_inverted_index.non‐patient | 10 |
| abstract_inverted_index.predominantly | 4 |
| abstract_inverted_index.spontaneously | 125, 227 |
| abstract_inverted_index.stakeholders, | 11 |
| abstract_inverted_index.uncertainties | 67, 314 |
| abstract_inverted_index.comorbidities. | 329 |
| abstract_inverted_index.comprehensible | 298 |
| abstract_inverted_index.individualized | 308 |
| abstract_inverted_index.administration, | 241 |
| abstract_inverted_index.characteristics | 115, 193, 229, 362 |
| abstract_inverted_index.hospitalization | 216 |
| abstract_inverted_index.patient‐based | 34 |
| abstract_inverted_index.characteristics. | 128, 252 |
| abstract_inverted_index.Decision‐makers | 2 |
| abstract_inverted_index.decision‐making | 391 |
| abstract_inverted_index.patient‐centred | 26 |
| abstract_inverted_index.semi‐structured | 90 |
| abstract_inverted_index.decision‐making, | 27 |
| abstract_inverted_index.decision‐making. | 310 |
| abstract_inverted_index.patient‐relevant | 361 |
| abstract_inverted_index.treatment‐related | 114 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/16 |
| sustainable_development_goals[0].score | 0.6600000262260437 |
| sustainable_development_goals[0].display_name | Peace, Justice and strong institutions |
| citation_normalized_percentile.value | 0.67653222 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |