Helicobacter pylori cagA, vacA and babA2 genotypes and gastroduodenal diseases: a cross-sectional study from the Mekong Delta of Vietnam Article Swipe
Thi Hong Nhung Thai
,
Thai Hoa Nguyen
,
Thi Mai Ngan Nguyen
,
Thi Minh Thi Ha
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1099/jmm.0.002096
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1099/jmm.0.002096
Introduction. The cagA and vacA genes encode the CagA and VacA proteins, which are the two main toxins of Helicobacter pylori . Regardless of whether the illness is benign or malignant, the majority of Asian H. pylori strains are cagA ( + ) and vacA s1 ( vacA signal region 1 allele); hence, these genotypes cannot account for the severity of gastroduodenal disease. Gap statement. The babA2 gene encodes the important adhesin BabA of H. pylori , which is crucial for persistent colonization and facilitates the translocation of CagA into host gastric epithelial cells. The synergic interaction of toxins, including CagA, VacA and BabA, could significantly contribute to the pathogenesis of H. pylori . The investigation of cagA , vacA and babA2 genes in clinical H. pylori isolates in Asian nations, particularly Vietnam, is insufficient. Aim. To investigate the cagA , vacA and babA2 genotypes to further understand their synergistic interaction in the development of gastroduodenal disease in Vietnamese populations. Methodology. A cross-sectional study was conducted on 169 H . pylori strains isolated from patients with gastroduodenal disease. The PCR assays were performed to determine the cagA , vacA and babA2 genotypes on DNA extracted from cultured H. pylori isolates. Results. The research showed that the percentage of the cagA (+), babA2 (+), vacA s1m1 and vacA s1m2 was 87.6%, 73.4%, 52.1% and 44.4%, respectively. The frequencies of cagA (+)/ babA2 (+)/ vacA s1m1 and cagA (+)/ babA2 (+)/ vacA s1m2 combinations were 44.4% and 28.4 %, respectively. The cagA (+)/ babA2 (+)/ vacA s1m2 combination was associated with peptic ulcer disease [adjusted odds ratio (aOR)=5.53, 95 % confidence interval (CI) 1.09–28.16, P =0.039] in male patients and chronic gastritis with precancerous lesions (aOR=5.31, 95 % CI 1.23–22.89, P =0.025) in female patients. Conclusion. The cagA (+)/ babA2 (+)/ vacA s1m1 and cagA (+)/ babA2 (+)/ vacA s1m2 combinations were found to be quite prevalent among Vietnamese H. pylori strains. The synergistic effect of cagA (+), babA2 (+) and vacA s1m2 in increasing the odds of both peptic ulcer disease and gastric precancerous lesions has been observed.
Related Topics
Concepts
CagA
Genotype
Biology
Helicobacter pylori
Pathogenesis
Gene
Bacterial adhesin
Microbiology
Virulence
Colonization
Disease
Vietnamese
Polymerase chain reaction
Virology
Host (biology)
Allele
Spirillaceae
Genetics
Immunology
Gastritis
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1099/jmm.0.002096
- OA Status
- hybrid
- References
- 50
- OpenAlex ID
- https://openalex.org/W7105923603
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7105923603Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1099/jmm.0.002096Digital Object Identifier
- Title
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Helicobacter pylori cagA, vacA and babA2 genotypes and gastroduodenal diseases: a cross-sectional study from the Mekong Delta of VietnamWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-11-18Full publication date if available
- Authors
-
Thi Hong Nhung Thai, Thai Hoa Nguyen, Thi Mai Ngan Nguyen, Thi Minh Thi HaList of authors in order
- Landing page
-
https://doi.org/10.1099/jmm.0.002096Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1099/jmm.0.002096Direct OA link when available
- Concepts
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CagA, Genotype, Biology, Helicobacter pylori, Pathogenesis, Gene, Bacterial adhesin, Microbiology, Virulence, Colonization, Disease, Vietnamese, Polymerase chain reaction, Virology, Host (biology), Allele, Spirillaceae, Genetics, Immunology, GastritisTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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50Number of works referenced by this work
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