Hematopoietic Stem Cell Transplantation Outcomes for High-Risk AML: A Report From the Children's Oncology Group Article Swipe
Benjamin J. Huang
,
Lauren K. Meyer
,
Todd A. Alonzo
,
Yicheng Wang
,
Adam J. Lamble
,
Rhonda E. Ries
,
Weijie Wang
,
Betsy Hirsch
,
Gordana Raca
,
Xiaotu Ma
,
Alan S. Gamis
,
Richard Aplenc
,
E. Anders Kolb
,
Todd M. Cooper
,
Katherine Tarlock
,
Michael R. Loken
,
Soheil Meshinchi
,
Joseph H. Chewning
,
William G. Woods
,
John Horan
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1200/jco-24-01841
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1200/jco-24-01841
PURPOSE Hematopoietic stem cell transplantation (HSCT) is used as consolidation for pediatric patients with high-risk AML in first complete remission (CR1). The definition of high-risk AML has evolved considerably over the past two decades with the successive identification of new unfavorable risk factors. We conducted a cross-study analysis to determine whether HSCT improves the outcomes of patients with contemporarily defined high-risk AML. METHODS We combined data from AAML0531 and AAML1031, the last two phase III clinical trials completed by the Children's Oncology Group (COG). These two trials established the prognostic importance of measurable residual disease (MRD) and several high-risk cryptic cytogenetic/molecular (CM) alterations, which were applied to reclassify patients in the current COG phase III clinical trial, AAML1831. We compared the outcomes after HSCT in CR1 with those after chemotherapy alone in CR1 in the redefined high-risk group. RESULTS Our study cohort comprised 463 patients with high-risk CM alterations and 72 patients with standard-risk (SR) CM results with positive MRD at end of induction I. In all, 33.9% and 45.8% of these groups underwent HSCT in CR1, respectively. HSCT was associated with decreased relapse and improved disease-free survival (DFS) in both groups. In the high-risk CM group, 5-year DFS was 26.0% (95% CI, 20.6 to 31.6) and 49.8% (95% CI, 41.7 to 57.4; P < .001) in patients receiving chemotherapy alone and HSCT, respectively. In the SR CM and MRD+ groups, DFS was 16.9% (95% CI, 4.3 to 36.7) compared with 50.9% (95% CI, 32.7 to 66.5; P = .032). HSCT was also associated with improvement in outcomes based on multivariable analysis and across subgroups defined by clinical trial and by high-risk CM subtype, with the exception of chromosome 7 or 5 loss. CONCLUSION HSCT was associated with improved outcomes in pediatric patients with contemporarily defined high-risk AML.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1200/jco-24-01841
- OA Status
- hybrid
- Cited By
- 1
- References
- 23
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409872690
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409872690Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1200/jco-24-01841Digital Object Identifier
- Title
-
Hematopoietic Stem Cell Transplantation Outcomes for High-Risk AML: A Report From the Children's Oncology GroupWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-28Full publication date if available
- Authors
-
Benjamin J. Huang, Lauren K. Meyer, Todd A. Alonzo, Yicheng Wang, Adam J. Lamble, Rhonda E. Ries, Weijie Wang, Betsy Hirsch, Gordana Raca, Xiaotu Ma, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Todd M. Cooper, Katherine Tarlock, Michael R. Loken, Soheil Meshinchi, Joseph H. Chewning, William G. Woods, John HoranList of authors in order
- Landing page
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https://doi.org/10.1200/jco-24-01841Publisher landing page
- Open access
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YesWhether a free full text is available
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-
hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1200/jco-24-01841Direct OA link when available
- Concepts
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Medicine, Internal medicine, Hematopoietic stem cell transplantation, Oncology, Transplantation, Chemotherapy, Minimal residual disease, Cohort, LeukemiaTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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23Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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