Hemoglobinopathies, Merozoite Surface Protein-2 Gene Polymorphisms, and Acquisition of Epstein Barr Virus Among Infants in Western Kenya Article Swipe
Perez K. Olewe
,
Shehu Shagari Awandu
,
Elly O. Munde
,
Samuel B. Anyona
,
Evans Raballah
,
Asito S. Amolo
,
Sidney Ogola
,
Erick Ndenga
,
Clinton Onyango
,
Rosemary Rochford
,
Douglas J. Perkins
,
Collins Ouma
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2175165/v1
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2175165/v1
Background Epstein Barr virus (EBV)-associated endemic Burkitt's Lymphoma pediatric cancer is associated with morbidity and mortality among children resident in holoendemic Plasmodium falciparum regions in western Kenya. P. falciparum exerts a strong selection pressure on sickle cell trait (SCT), alpha thalassemia (-α 3.7 /αα), glucose-6-phosphate dehydrogenase (G6PD), and merozoite surface protein 2 (MSP-2) variants (FC27, 3D7) that confer reduced malarial disease severity Methods Data on infant EBV infection status (A)/Chinese (1024C>T) (OR=2.614, P= 0.212)] and [Union (1360C>T)/Kaiping (1388G>A) (OR=0.321 , P =0.295)]. There was no relationship between EBV acquisition and in utero exposure to either FC27 (OR=0.922, P= 0.914) or 3D7 (OR=0.933, P= 0.921). In addition, EBV acquisition in infants ≥6-12 months also showed no association with -α 3.7 /αα (OR=0.681, P =0.442), SCT (OR=0.513, P =0.305), G6PD [(Viangchan (871G>A)/Chinese (1024C>T) (OR=0.640, P =0.677)], [Mahidol (487G>A)/Coimbra (592C>T) (OR=0.948, P =0.940)], [(Union (1360C>T)/Kaiping (1388G>A) (OR=1.221, P =0.768)], African A (OR=0.278, P =0.257)], or in utero exposure to either FC27 (OR=0.780, P =0.662) or 3D7 (OR=0.549, P =0.241). Conclusion: Although hemoglobinopathies (-α 3.7 /αα, SCT, and G6PD mutations) and in utero exposure to MSP-2 was not associated with EBV acquisition in infants 0-12 months, novel G6PD variants were discovered in the population from western Kenya. To definitely establish that the known and novel hemoglobinopathies, and in utero MSP-2 exposure do not confer susceptibility to EBV, future studies with larger sample sizes are required.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-2175165/v1
- https://www.researchsquare.com/article/rs-2175165/latest.pdf
- OA Status
- green
- Cited By
- 1
- References
- 80
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4309268430
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4309268430Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-2175165/v1Digital Object Identifier
- Title
-
Hemoglobinopathies, Merozoite Surface Protein-2 Gene Polymorphisms, and Acquisition of Epstein Barr Virus Among Infants in Western KenyaWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-11-17Full publication date if available
- Authors
-
Perez K. Olewe, Shehu Shagari Awandu, Elly O. Munde, Samuel B. Anyona, Evans Raballah, Asito S. Amolo, Sidney Ogola, Erick Ndenga, Clinton Onyango, Rosemary Rochford, Douglas J. Perkins, Collins OumaList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-2175165/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-2175165/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-2175165/latest.pdfDirect OA link when available
- Concepts
-
Genotyping, Biology, Genotype, In utero, Virology, Immunology, Merozoite surface protein, Single-nucleotide polymorphism, Medicine, Gene, Plasmodium falciparum, Malaria, Genetics, Fetus, Malaria vaccine, PregnancyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1Per-year citation counts (last 5 years)
- References (count)
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80Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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