HER2 expression in different cell lines at different inoculation sites assessed by [52Mn]Mn-DOTAGA(anhydride)-trastuzumab Article Swipe
Toàn Minh Ngô
,
Adrienn Vágner
,
G. Nagy
,
Gábor Ország
,
Tamás Nagy
,
Zoltán Szoboszlai
,
Csaba Csikos
,
Balázs Váradi
,
György Trencsényi
,
Gyula Tircsó
,
Ildikó Garai
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/pore.2025.1611999
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/pore.2025.1611999
Purpose Positron emission tomography (PET) hybrid imaging targeting HER2 requires antibodies labelled with longer half-life isotopes. With a suitable radiation profile, 52 Mn coupled with DOTAGA as a bifunctional chelator is a potential candidate. In this study, we investigated the tumor HER2 specificity and the temporal biodistribution of the [ 52 Mn]Mn-DOTAGA(anhydride)-trastuzumab in preclinical models. Methods PET/MRI and PET/CT were performed on SCID mice bearing orthotopic and ectopic HER2-positive and ectopic HER2-negative tumors at 4, 24, 48, 72, and 120 h post-injection with [ 52 Mn]Mn-DOTAGA(anhydride)-trastuzumab. Melanoma xenografts were included for comparison of specificity. Results In vivo biodistribution demonstrated strong contrast in HER2-positive tumors, particularly in orthotopic tumors, where uptake was significantly higher than in the blood pool and other organs from 24 h onwards and consistently higher than in ectopic HER2-positive tumors at all time points. Significantly higher tumor-to-blood and tumor-to-muscle ratios were observed in HER2-positive ectopic tumors compared to HER2-negative tumors but only at 4 and 24 h; the differences were likely due to non-specific binding of the tracer. The ratios for orthotopic HER2-positive tumors were significantly higher than those for ectopic HER2-negative tumors and melanoma at all time points. However, the differences between HER2-positive and HER2-negative tumors decreased at later time points. Conclusion These results suggest that [ 52 Mn]Mn-DOTAGA(anhydride)-trastuzumab demonstrates efficient tumor-to-background contrast, emphasize the higher tumor uptake observed in orthotopic tumors, and highlight the influence of tumor environment characteristics on uptake.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/pore.2025.1611999
- https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2025.1611999/pdf
- OA Status
- gold
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409959546
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409959546Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/pore.2025.1611999Digital Object Identifier
- Title
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HER2 expression in different cell lines at different inoculation sites assessed by [52Mn]Mn-DOTAGA(anhydride)-trastuzumabWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-29Full publication date if available
- Authors
-
Toàn Minh Ngô, Adrienn Vágner, G. Nagy, Gábor Ország, Tamás Nagy, Zoltán Szoboszlai, Csaba Csikos, Balázs Váradi, György Trencsényi, Gyula Tircsó, Ildikó GaraiList of authors in order
- Landing page
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https://doi.org/10.3389/pore.2025.1611999Publisher landing page
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https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2025.1611999/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2025.1611999/pdfDirect OA link when available
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Trastuzumab, Inoculation, Cell culture, Chemistry, Molecular biology, Biology, Medicine, Internal medicine, Immunology, Cancer, Genetics, Breast cancerTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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63Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Conclusion | 205 |
| abstract_inverted_index.antibodies | 10 |
| abstract_inverted_index.candidate. | 33 |
| abstract_inverted_index.comparison | 91 |
| abstract_inverted_index.orthotopic | 65, 106, 174, 224 |
| abstract_inverted_index.tomography | 3 |
| abstract_inverted_index.xenografts | 87 |
| abstract_inverted_index.differences | 161, 194 |
| abstract_inverted_index.environment | 232 |
| abstract_inverted_index.preclinical | 53 |
| abstract_inverted_index.specificity | 42 |
| abstract_inverted_index.bifunctional | 28 |
| abstract_inverted_index.consistently | 126 |
| abstract_inverted_index.demonstrated | 98 |
| abstract_inverted_index.demonstrates | 213 |
| abstract_inverted_index.investigated | 38 |
| abstract_inverted_index.non-specific | 166 |
| abstract_inverted_index.particularly | 104 |
| abstract_inverted_index.specificity. | 93 |
| abstract_inverted_index.HER2-negative | 71, 151, 184, 198 |
| abstract_inverted_index.HER2-positive | 68, 102, 131, 146, 175, 196 |
| abstract_inverted_index.Significantly | 137 |
| abstract_inverted_index.significantly | 111, 178 |
| abstract_inverted_index.post-injection | 81 |
| abstract_inverted_index.tumor-to-blood | 139 |
| abstract_inverted_index.biodistribution | 46, 97 |
| abstract_inverted_index.characteristics | 233 |
| abstract_inverted_index.tumor-to-muscle | 141 |
| abstract_inverted_index.tumor-to-background | 215 |
| abstract_inverted_index.Mn]Mn-DOTAGA(anhydride)-trastuzumab | 51, 212 |
| abstract_inverted_index.Mn]Mn-DOTAGA(anhydride)-trastuzumab. | 85 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| citation_normalized_percentile.value | 0.21628929 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |