HER2/neu-Based Peptide Vaccination-Pulsed with B-Cell Epitope Induced Efficient Prophylactic and Therapeutic Antitumor Activities in TUBO Breast Cancer Mice Model Article Swipe
Muhammad Luqman Nordin
,
Abdin Shakirin Mohamad Norpi
,
Pei Yuen Ng
,
Khatijah Yusoff
,
Nadiah Abu
,
Kue Peng Lim
,
Fazren Azmi
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/cancers13194958
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/cancers13194958
Breast cancer is the most common invasive cancer diagnosed among women. A cancer vaccine has been recognized as a form of immunotherapy with a prominent position in the prevention and treatment of breast cancer. The majority of current breast cancer vaccination strategies aim to stimulate antitumor T-cell responses of the HER2/neu oncogene, which is abnormally expressed in breast cancer cells. However, the role of the B-cell humoral response is often underappreciated in the cancer vaccine design. We have advanced this idea by elucidating the role of B-cells in cancer vaccination by designing a chimeric antigenic peptide possessing both cytotoxic T lymphocytes (GP2) and B-cell (P4) peptide epitopes derived from HER2/neu. The chimeric peptide (GP2–P4) was further conjugated to a carrier protein (KLH), forming a KLH–GP2–P4 conjugate. The immunogenicity of KLH–GP2–P4 was compared with KLH–GP2 (lacking the B-cell epitope) in BALB/c mice. Mice immunized with KLH–GP2–P4 elicited more potent antigen-specific neutralizing antibodies against syngeneic TUBO cells (cancer cell line overexpressing HER2/neu) that was governed by a balanced Th1/Th2 polarization in comparison to KLH–GP2. Subsequently, these immune responses led to greater inhibition of tumor growth and longer survival in TUBO tumor-bearing mice in both prophylactic and therapeutic challenge experiments. Overall, our data demonstrated that the B-cell epitope has a profound effect in orchestrating an efficacious antitumor immunity. Thus, a multi-epitope peptide vaccine encompassing cytotoxic T-lymphocytes, T-helper and B-cell epitopes represents a promising strategy in developing cancer vaccines with a preventive and therapeutic modality for the effective management of breast cancer.
Related Topics
Concepts
Epitope
Cytotoxic T cell
Cancer vaccine
Immunogenicity
Immunotherapy
Cancer
Peptide vaccine
Immunology
Antigen
Breast cancer
Immune system
Cancer research
T cell
Cancer immunotherapy
Vaccination
Medicine
Biology
Internal medicine
In vitro
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers13194958
- https://www.mdpi.com/2072-6694/13/19/4958/pdf?version=1633771142
- OA Status
- gold
- Cited By
- 21
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3201743683
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3201743683Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cancers13194958Digital Object Identifier
- Title
-
HER2/neu-Based Peptide Vaccination-Pulsed with B-Cell Epitope Induced Efficient Prophylactic and Therapeutic Antitumor Activities in TUBO Breast Cancer Mice ModelWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-10-01Full publication date if available
- Authors
-
Muhammad Luqman Nordin, Abdin Shakirin Mohamad Norpi, Pei Yuen Ng, Khatijah Yusoff, Nadiah Abu, Kue Peng Lim, Fazren AzmiList of authors in order
- Landing page
-
https://doi.org/10.3390/cancers13194958Publisher landing page
- PDF URL
-
https://www.mdpi.com/2072-6694/13/19/4958/pdf?version=1633771142Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2072-6694/13/19/4958/pdf?version=1633771142Direct OA link when available
- Concepts
-
Epitope, Cytotoxic T cell, Cancer vaccine, Immunogenicity, Immunotherapy, Cancer, Peptide vaccine, Immunology, Antigen, Breast cancer, Immune system, Cancer research, T cell, Cancer immunotherapy, Vaccination, Medicine, Biology, Internal medicine, In vitro, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
21Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 4, 2023: 6, 2022: 4Per-year citation counts (last 5 years)
- References (count)
-
49Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3201743683 |
|---|---|
| doi | https://doi.org/10.3390/cancers13194958 |
| ids.doi | https://doi.org/10.3390/cancers13194958 |
| ids.mag | 3201743683 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/34638441 |
| ids.openalex | https://openalex.org/W3201743683 |
| fwci | 1.44510141 |
| type | article |
| title | HER2/neu-Based Peptide Vaccination-Pulsed with B-Cell Epitope Induced Efficient Prophylactic and Therapeutic Antitumor Activities in TUBO Breast Cancer Mice Model |
| biblio.issue | 19 |
| biblio.volume | 13 |
| biblio.last_page | 4958 |
| biblio.first_page | 4958 |
| grants[0].funder | https://openalex.org/F4320321709 |
| grants[0].award_id | FRGS/1/2019/SKK06/UKM/02/5 |
| grants[0].funder_display_name | Ministry of Higher Education, Malaysia |
| topics[0].id | https://openalex.org/T10580 |
| topics[0].field.id | https://openalex.org/fields/24 |
| topics[0].field.display_name | Immunology and Microbiology |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2403 |
| topics[0].subfield.display_name | Immunology |
| topics[0].display_name | Immunotherapy and Immune Responses |
| topics[1].id | https://openalex.org/T12576 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9994999766349792 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | vaccines and immunoinformatics approaches |
| topics[2].id | https://openalex.org/T11016 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9994000196456909 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2741 |
| topics[2].subfield.display_name | Radiology, Nuclear Medicine and Imaging |
| topics[2].display_name | Monoclonal and Polyclonal Antibodies Research |
| funders[0].id | https://openalex.org/F4320321709 |
| funders[0].ror | https://ror.org/05mcs2t73 |
| funders[0].display_name | Ministry of Higher Education, Malaysia |
| is_xpac | False |
| apc_list.value | 2400 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2598 |
| apc_paid.value | 2400 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2598 |
| concepts[0].id | https://openalex.org/C195616568 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8759495615959167 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q128711 |
| concepts[0].display_name | Epitope |
| concepts[1].id | https://openalex.org/C154317977 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6767204403877258 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q376266 |
| concepts[1].display_name | Cytotoxic T cell |
| concepts[2].id | https://openalex.org/C2778378633 |
| concepts[2].level | 4 |
| concepts[2].score | 0.6055826544761658 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q2378309 |
| concepts[2].display_name | Cancer vaccine |
| concepts[3].id | https://openalex.org/C2780868878 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5617374777793884 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1660197 |
| concepts[3].display_name | Immunogenicity |
| concepts[4].id | https://openalex.org/C2777701055 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5429421067237854 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1427096 |
| concepts[4].display_name | Immunotherapy |
| concepts[5].id | https://openalex.org/C121608353 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5386879444122314 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[5].display_name | Cancer |
| concepts[6].id | https://openalex.org/C2776789287 |
| concepts[6].level | 4 |
| concepts[6].score | 0.5327532291412354 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7166532 |
| concepts[6].display_name | Peptide vaccine |
| concepts[7].id | https://openalex.org/C203014093 |
| concepts[7].level | 1 |
| concepts[7].score | 0.5314344763755798 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[7].display_name | Immunology |
| concepts[8].id | https://openalex.org/C147483822 |
| concepts[8].level | 2 |
| concepts[8].score | 0.5273295640945435 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q103537 |
| concepts[8].display_name | Antigen |
| concepts[9].id | https://openalex.org/C530470458 |
| concepts[9].level | 3 |
| concepts[9].score | 0.5218690633773804 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q128581 |
| concepts[9].display_name | Breast cancer |
| concepts[10].id | https://openalex.org/C8891405 |
| concepts[10].level | 2 |
| concepts[10].score | 0.4954105615615845 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[10].display_name | Immune system |
| concepts[11].id | https://openalex.org/C502942594 |
| concepts[11].level | 1 |
| concepts[11].score | 0.49372681975364685 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[11].display_name | Cancer research |
| concepts[12].id | https://openalex.org/C2776090121 |
| concepts[12].level | 3 |
| concepts[12].score | 0.48919013142585754 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q193529 |
| concepts[12].display_name | T cell |
| concepts[13].id | https://openalex.org/C2780674031 |
| concepts[13].level | 4 |
| concepts[13].score | 0.47017258405685425 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q2012719 |
| concepts[13].display_name | Cancer immunotherapy |
| concepts[14].id | https://openalex.org/C22070199 |
| concepts[14].level | 2 |
| concepts[14].score | 0.45015332102775574 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q192995 |
| concepts[14].display_name | Vaccination |
| concepts[15].id | https://openalex.org/C71924100 |
| concepts[15].level | 0 |
| concepts[15].score | 0.44266238808631897 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[15].display_name | Medicine |
| concepts[16].id | https://openalex.org/C86803240 |
| concepts[16].level | 0 |
| concepts[16].score | 0.35847413539886475 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[16].display_name | Biology |
| concepts[17].id | https://openalex.org/C126322002 |
| concepts[17].level | 1 |
| concepts[17].score | 0.18732208013534546 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[17].display_name | Internal medicine |
| concepts[18].id | https://openalex.org/C202751555 |
| concepts[18].level | 2 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[18].display_name | In vitro |
| concepts[19].id | https://openalex.org/C55493867 |
| concepts[19].level | 1 |
| concepts[19].score | 0.0 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[19].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/epitope |
| keywords[0].score | 0.8759495615959167 |
| keywords[0].display_name | Epitope |
| keywords[1].id | https://openalex.org/keywords/cytotoxic-t-cell |
| keywords[1].score | 0.6767204403877258 |
| keywords[1].display_name | Cytotoxic T cell |
| keywords[2].id | https://openalex.org/keywords/cancer-vaccine |
| keywords[2].score | 0.6055826544761658 |
| keywords[2].display_name | Cancer vaccine |
| keywords[3].id | https://openalex.org/keywords/immunogenicity |
| keywords[3].score | 0.5617374777793884 |
| keywords[3].display_name | Immunogenicity |
| keywords[4].id | https://openalex.org/keywords/immunotherapy |
| keywords[4].score | 0.5429421067237854 |
| keywords[4].display_name | Immunotherapy |
| keywords[5].id | https://openalex.org/keywords/cancer |
| keywords[5].score | 0.5386879444122314 |
| keywords[5].display_name | Cancer |
| keywords[6].id | https://openalex.org/keywords/peptide-vaccine |
| keywords[6].score | 0.5327532291412354 |
| keywords[6].display_name | Peptide vaccine |
| keywords[7].id | https://openalex.org/keywords/immunology |
| keywords[7].score | 0.5314344763755798 |
| keywords[7].display_name | Immunology |
| keywords[8].id | https://openalex.org/keywords/antigen |
| keywords[8].score | 0.5273295640945435 |
| keywords[8].display_name | Antigen |
| keywords[9].id | https://openalex.org/keywords/breast-cancer |
| keywords[9].score | 0.5218690633773804 |
| keywords[9].display_name | Breast cancer |
| keywords[10].id | https://openalex.org/keywords/immune-system |
| keywords[10].score | 0.4954105615615845 |
| keywords[10].display_name | Immune system |
| keywords[11].id | https://openalex.org/keywords/cancer-research |
| keywords[11].score | 0.49372681975364685 |
| keywords[11].display_name | Cancer research |
| keywords[12].id | https://openalex.org/keywords/t-cell |
| keywords[12].score | 0.48919013142585754 |
| keywords[12].display_name | T cell |
| keywords[13].id | https://openalex.org/keywords/cancer-immunotherapy |
| keywords[13].score | 0.47017258405685425 |
| keywords[13].display_name | Cancer immunotherapy |
| keywords[14].id | https://openalex.org/keywords/vaccination |
| keywords[14].score | 0.45015332102775574 |
| keywords[14].display_name | Vaccination |
| keywords[15].id | https://openalex.org/keywords/medicine |
| keywords[15].score | 0.44266238808631897 |
| keywords[15].display_name | Medicine |
| keywords[16].id | https://openalex.org/keywords/biology |
| keywords[16].score | 0.35847413539886475 |
| keywords[16].display_name | Biology |
| keywords[17].id | https://openalex.org/keywords/internal-medicine |
| keywords[17].score | 0.18732208013534546 |
| keywords[17].display_name | Internal medicine |
| language | en |
| locations[0].id | doi:10.3390/cancers13194958 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S168415115 |
| locations[0].source.issn | 2072-6694 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2072-6694 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Cancers |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2072-6694/13/19/4958/pdf?version=1633771142 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cancers |
| locations[0].landing_page_url | https://doi.org/10.3390/cancers13194958 |
| locations[1].id | pmid:34638441 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cancers |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/34638441 |
| locations[2].id | pmh:oai:doaj.org/article:5fe2504d58ca4f0d8520db49d5dcdda5 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].source.host_organization_lineage | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Cancers, Vol 13, Iss 4958, p 4958 (2021) |
| locations[2].landing_page_url | https://doaj.org/article/5fe2504d58ca4f0d8520db49d5dcdda5 |
| locations[3].id | pmh:oai:mdpi.com:/2072-6694/13/19/4958/ |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400947 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | True |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | MDPI (MDPI AG) |
| locations[3].source.host_organization | https://openalex.org/I4210097602 |
| locations[3].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[3].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Cancers; Volume 13; Issue 19; Pages: 4958 |
| locations[3].landing_page_url | https://dx.doi.org/10.3390/cancers13194958 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:8507975 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Cancers (Basel) |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8507975 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5066479156 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-2780-1065 |
| authorships[0].author.display_name | Muhammad Luqman Nordin |
| authorships[0].countries | MY |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I885383172 |
| authorships[0].affiliations[0].raw_affiliation_string | Centre for Drug Delivery Technology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM) Kuala Lumpur Campus, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I226432 |
| authorships[0].affiliations[1].raw_affiliation_string | Department of Clinical Studies, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan (UMK), Pengkalan Chepa, Kota Bharu 16100, Kelantan, Malaysia |
| authorships[0].institutions[0].id | https://openalex.org/I885383172 |
| authorships[0].institutions[0].ror | https://ror.org/00bw8d226 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I885383172 |
| authorships[0].institutions[0].country_code | MY |
| authorships[0].institutions[0].display_name | National University of Malaysia |
| authorships[0].institutions[1].id | https://openalex.org/I226432 |
| authorships[0].institutions[1].ror | https://ror.org/0463y2v87 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I226432 |
| authorships[0].institutions[1].country_code | MY |
| authorships[0].institutions[1].display_name | Universiti Malaysia Kelantan |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Muhammad Luqman Nordin |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Centre for Drug Delivery Technology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM) Kuala Lumpur Campus, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia, Department of Clinical Studies, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan (UMK), Pengkalan Chepa, Kota Bharu 16100, Kelantan, Malaysia |
| authorships[1].author.id | https://openalex.org/A5059765265 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Abdin Shakirin Mohamad Norpi |
| authorships[1].countries | MY |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I885383172 |
| authorships[1].affiliations[0].raw_affiliation_string | Centre for Drug Delivery Technology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM) Kuala Lumpur Campus, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I4528857 |
| authorships[1].affiliations[1].raw_affiliation_string | Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, No.3 Jalan Greentown, Ipoh 30450, Perak, Malaysia |
| authorships[1].institutions[0].id | https://openalex.org/I885383172 |
| authorships[1].institutions[0].ror | https://ror.org/00bw8d226 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I885383172 |
| authorships[1].institutions[0].country_code | MY |
| authorships[1].institutions[0].display_name | National University of Malaysia |
| authorships[1].institutions[1].id | https://openalex.org/I4528857 |
| authorships[1].institutions[1].ror | https://ror.org/026wwrx19 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I4528857 |
| authorships[1].institutions[1].country_code | MY |
| authorships[1].institutions[1].display_name | University of Kuala Lumpur |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Abdin Shakirin Mohamad Norpi |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Centre for Drug Delivery Technology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM) Kuala Lumpur Campus, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia, Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, No.3 Jalan Greentown, Ipoh 30450, Perak, Malaysia |
| authorships[2].author.id | https://openalex.org/A5043075559 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-2340-6682 |
| authorships[2].author.display_name | Pei Yuen Ng |
| authorships[2].countries | MY |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I885383172 |
| authorships[2].affiliations[0].raw_affiliation_string | Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM), Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia |
| authorships[2].institutions[0].id | https://openalex.org/I885383172 |
| authorships[2].institutions[0].ror | https://ror.org/00bw8d226 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I885383172 |
| authorships[2].institutions[0].country_code | MY |
| authorships[2].institutions[0].display_name | National University of Malaysia |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Pei Yuen Ng |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM), Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia |
| authorships[3].author.id | https://openalex.org/A5022895144 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Khatijah Yusoff |
| authorships[3].countries | MY |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I130343225, https://openalex.org/I4210162021 |
| authorships[3].affiliations[0].raw_affiliation_string | UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia (UPM), Serdang, Seri Kembangan 43400, Selangor, Malaysia |
| authorships[3].institutions[0].id | https://openalex.org/I4210162021 |
| authorships[3].institutions[0].ror | https://ror.org/05th36r26 |
| authorships[3].institutions[0].type | nonprofit |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210162021 |
| authorships[3].institutions[0].country_code | MY |
| authorships[3].institutions[0].display_name | National Cancer Council Malaysia |
| authorships[3].institutions[1].id | https://openalex.org/I130343225 |
| authorships[3].institutions[1].ror | https://ror.org/02e91jd64 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I130343225 |
| authorships[3].institutions[1].country_code | MY |
| authorships[3].institutions[1].display_name | Universiti Putra Malaysia |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Khatijah Yusoff |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia (UPM), Serdang, Seri Kembangan 43400, Selangor, Malaysia |
| authorships[4].author.id | https://openalex.org/A5024315711 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1488-2951 |
| authorships[4].author.display_name | Nadiah Abu |
| authorships[4].countries | MY |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I2801594805 |
| authorships[4].affiliations[0].raw_affiliation_string | UKM Medical Molecular Biology Institute (UMBI), UKM Medical Centre, Jalan Ya'acob Latiff, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia |
| authorships[4].institutions[0].id | https://openalex.org/I2801594805 |
| authorships[4].institutions[0].ror | https://ror.org/01590nj79 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I2801594805 |
| authorships[4].institutions[0].country_code | MY |
| authorships[4].institutions[0].display_name | University Kebangsaan Malaysia Medical Centre |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Nadiah Abu |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | UKM Medical Molecular Biology Institute (UMBI), UKM Medical Centre, Jalan Ya'acob Latiff, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia |
| authorships[5].author.id | https://openalex.org/A5109546108 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-5670-8070 |
| authorships[5].author.display_name | Kue Peng Lim |
| authorships[5].countries | MY |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210092640 |
| authorships[5].affiliations[0].raw_affiliation_string | Cancer Immunology & Immunotherapy Unit, Cancer Research Malaysia, No. 1 Jalan SS12/1A, Subang Jaya 47500, Selangor, Malaysia |
| authorships[5].institutions[0].id | https://openalex.org/I4210092640 |
| authorships[5].institutions[0].ror | https://ror.org/00g0aq541 |
| authorships[5].institutions[0].type | nonprofit |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210092640, https://openalex.org/I4210147568 |
| authorships[5].institutions[0].country_code | MY |
| authorships[5].institutions[0].display_name | Cancer Research Malaysia |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Kue Peng Lim |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Cancer Immunology & Immunotherapy Unit, Cancer Research Malaysia, No. 1 Jalan SS12/1A, Subang Jaya 47500, Selangor, Malaysia |
| authorships[6].author.id | https://openalex.org/A5064647317 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-8680-4952 |
| authorships[6].author.display_name | Fazren Azmi |
| authorships[6].countries | MY |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I885383172 |
| authorships[6].affiliations[0].raw_affiliation_string | Centre for Drug Delivery Technology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM) Kuala Lumpur Campus, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia |
| authorships[6].institutions[0].id | https://openalex.org/I885383172 |
| authorships[6].institutions[0].ror | https://ror.org/00bw8d226 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I885383172 |
| authorships[6].institutions[0].country_code | MY |
| authorships[6].institutions[0].display_name | National University of Malaysia |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Fazren Azmi |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Centre for Drug Delivery Technology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM) Kuala Lumpur Campus, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2072-6694/13/19/4958/pdf?version=1633771142 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | HER2/neu-Based Peptide Vaccination-Pulsed with B-Cell Epitope Induced Efficient Prophylactic and Therapeutic Antitumor Activities in TUBO Breast Cancer Mice Model |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10580 |
| primary_topic.field.id | https://openalex.org/fields/24 |
| primary_topic.field.display_name | Immunology and Microbiology |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2403 |
| primary_topic.subfield.display_name | Immunology |
| primary_topic.display_name | Immunotherapy and Immune Responses |
| related_works | https://openalex.org/W2019183242, https://openalex.org/W2093686365, https://openalex.org/W2356693239, https://openalex.org/W2363997565, https://openalex.org/W4321482651, https://openalex.org/W4212864102, https://openalex.org/W2586859946, https://openalex.org/W4361871499, https://openalex.org/W4361871545, https://openalex.org/W2093473090 |
| cited_by_count | 21 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 7 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 4 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 6 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 4 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3390/cancers13194958 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S168415115 |
| best_oa_location.source.issn | 2072-6694 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2072-6694 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Cancers |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2072-6694/13/19/4958/pdf?version=1633771142 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cancers |
| best_oa_location.landing_page_url | https://doi.org/10.3390/cancers13194958 |
| primary_location.id | doi:10.3390/cancers13194958 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S168415115 |
| primary_location.source.issn | 2072-6694 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2072-6694 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Cancers |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2072-6694/13/19/4958/pdf?version=1633771142 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cancers |
| primary_location.landing_page_url | https://doi.org/10.3390/cancers13194958 |
| publication_date | 2021-10-01 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2146363401, https://openalex.org/W3128646645, https://openalex.org/W6775044204, https://openalex.org/W2917660960, https://openalex.org/W6677665313, https://openalex.org/W6783738902, https://openalex.org/W3100764583, https://openalex.org/W2765531575, https://openalex.org/W2918899673, https://openalex.org/W2216203568, https://openalex.org/W2765766142, https://openalex.org/W6718928337, https://openalex.org/W3118922441, https://openalex.org/W6677610855, https://openalex.org/W2890854864, https://openalex.org/W1953817170, https://openalex.org/W2180645599, https://openalex.org/W1975123569, https://openalex.org/W1901376705, https://openalex.org/W1983059051, https://openalex.org/W2996988336, https://openalex.org/W2698159436, https://openalex.org/W1584781246, https://openalex.org/W1978480169, https://openalex.org/W6681619728, https://openalex.org/W2587672885, https://openalex.org/W2997796122, https://openalex.org/W1981410615, https://openalex.org/W3004826140, https://openalex.org/W2148968806, https://openalex.org/W2695058080, https://openalex.org/W2800894321, https://openalex.org/W2341719138, https://openalex.org/W2272845509, https://openalex.org/W2027348480, https://openalex.org/W2129665972, https://openalex.org/W2156491299, https://openalex.org/W2884091495, https://openalex.org/W3020308181, https://openalex.org/W3009580616, https://openalex.org/W2790884126, https://openalex.org/W2755831618, https://openalex.org/W3163011301, https://openalex.org/W2048954527, https://openalex.org/W2461186391, https://openalex.org/W3089759173, https://openalex.org/W3011352832, https://openalex.org/W2120514976, https://openalex.org/W2115439647 |
| referenced_works_count | 49 |
| abstract_inverted_index.A | 11 |
| abstract_inverted_index.T | 99 |
| abstract_inverted_index.a | 18, 23, 92, 118, 123, 164, 206, 216, 228, 236 |
| abstract_inverted_index.We | 76 |
| abstract_inverted_index.an | 211 |
| abstract_inverted_index.as | 17 |
| abstract_inverted_index.by | 81, 90, 163 |
| abstract_inverted_index.in | 26, 56, 71, 87, 138, 168, 186, 190, 209, 231 |
| abstract_inverted_index.is | 2, 53, 68 |
| abstract_inverted_index.of | 20, 31, 36, 48, 63, 85, 128, 180, 245 |
| abstract_inverted_index.to | 43, 117, 170, 177 |
| abstract_inverted_index.The | 34, 110, 126 |
| abstract_inverted_index.aim | 42 |
| abstract_inverted_index.and | 29, 102, 183, 193, 224, 238 |
| abstract_inverted_index.for | 241 |
| abstract_inverted_index.has | 14, 205 |
| abstract_inverted_index.led | 176 |
| abstract_inverted_index.our | 198 |
| abstract_inverted_index.the | 3, 27, 49, 61, 64, 72, 83, 135, 202, 242 |
| abstract_inverted_index.was | 114, 130, 161 |
| abstract_inverted_index.(P4) | 104 |
| abstract_inverted_index.Mice | 141 |
| abstract_inverted_index.TUBO | 153, 187 |
| abstract_inverted_index.been | 15 |
| abstract_inverted_index.both | 97, 191 |
| abstract_inverted_index.cell | 156 |
| abstract_inverted_index.data | 199 |
| abstract_inverted_index.form | 19 |
| abstract_inverted_index.from | 108 |
| abstract_inverted_index.have | 77 |
| abstract_inverted_index.idea | 80 |
| abstract_inverted_index.line | 157 |
| abstract_inverted_index.mice | 189 |
| abstract_inverted_index.more | 146 |
| abstract_inverted_index.most | 4 |
| abstract_inverted_index.role | 62, 84 |
| abstract_inverted_index.that | 160, 201 |
| abstract_inverted_index.this | 79 |
| abstract_inverted_index.with | 22, 132, 143, 235 |
| abstract_inverted_index.(GP2) | 101 |
| abstract_inverted_index.Thus, | 215 |
| abstract_inverted_index.among | 9 |
| abstract_inverted_index.cells | 154 |
| abstract_inverted_index.mice. | 140 |
| abstract_inverted_index.often | 69 |
| abstract_inverted_index.these | 173 |
| abstract_inverted_index.tumor | 181 |
| abstract_inverted_index.which | 52 |
| abstract_inverted_index.(KLH), | 121 |
| abstract_inverted_index.B-cell | 65, 103, 136, 203, 225 |
| abstract_inverted_index.BALB/c | 139 |
| abstract_inverted_index.Breast | 0 |
| abstract_inverted_index.T-cell | 46 |
| abstract_inverted_index.breast | 32, 38, 57, 246 |
| abstract_inverted_index.cancer | 1, 7, 12, 39, 58, 73, 88, 233 |
| abstract_inverted_index.cells. | 59 |
| abstract_inverted_index.common | 5 |
| abstract_inverted_index.effect | 208 |
| abstract_inverted_index.growth | 182 |
| abstract_inverted_index.immune | 174 |
| abstract_inverted_index.longer | 184 |
| abstract_inverted_index.potent | 147 |
| abstract_inverted_index.women. | 10 |
| abstract_inverted_index.(cancer | 155 |
| abstract_inverted_index.B-cells | 86 |
| abstract_inverted_index.Th1/Th2 | 166 |
| abstract_inverted_index.against | 151 |
| abstract_inverted_index.cancer. | 33, 247 |
| abstract_inverted_index.carrier | 119 |
| abstract_inverted_index.current | 37 |
| abstract_inverted_index.derived | 107 |
| abstract_inverted_index.design. | 75 |
| abstract_inverted_index.epitope | 204 |
| abstract_inverted_index.forming | 122 |
| abstract_inverted_index.further | 115 |
| abstract_inverted_index.greater | 178 |
| abstract_inverted_index.humoral | 66 |
| abstract_inverted_index.peptide | 95, 105, 112, 218 |
| abstract_inverted_index.protein | 120 |
| abstract_inverted_index.vaccine | 13, 74, 219 |
| abstract_inverted_index.(lacking | 134 |
| abstract_inverted_index.HER2/neu | 50 |
| abstract_inverted_index.However, | 60 |
| abstract_inverted_index.Overall, | 197 |
| abstract_inverted_index.T-helper | 223 |
| abstract_inverted_index.advanced | 78 |
| abstract_inverted_index.balanced | 165 |
| abstract_inverted_index.chimeric | 93, 111 |
| abstract_inverted_index.compared | 131 |
| abstract_inverted_index.elicited | 145 |
| abstract_inverted_index.epitope) | 137 |
| abstract_inverted_index.epitopes | 106, 226 |
| abstract_inverted_index.governed | 162 |
| abstract_inverted_index.invasive | 6 |
| abstract_inverted_index.majority | 35 |
| abstract_inverted_index.modality | 240 |
| abstract_inverted_index.position | 25 |
| abstract_inverted_index.profound | 207 |
| abstract_inverted_index.response | 67 |
| abstract_inverted_index.strategy | 230 |
| abstract_inverted_index.survival | 185 |
| abstract_inverted_index.vaccines | 234 |
| abstract_inverted_index.HER2/neu) | 159 |
| abstract_inverted_index.HER2/neu. | 109 |
| abstract_inverted_index.KLH–GP2 | 133 |
| abstract_inverted_index.antigenic | 94 |
| abstract_inverted_index.antitumor | 45, 213 |
| abstract_inverted_index.challenge | 195 |
| abstract_inverted_index.cytotoxic | 98, 221 |
| abstract_inverted_index.designing | 91 |
| abstract_inverted_index.diagnosed | 8 |
| abstract_inverted_index.effective | 243 |
| abstract_inverted_index.expressed | 55 |
| abstract_inverted_index.immunity. | 214 |
| abstract_inverted_index.immunized | 142 |
| abstract_inverted_index.oncogene, | 51 |
| abstract_inverted_index.prominent | 24 |
| abstract_inverted_index.promising | 229 |
| abstract_inverted_index.responses | 47, 175 |
| abstract_inverted_index.stimulate | 44 |
| abstract_inverted_index.syngeneic | 152 |
| abstract_inverted_index.treatment | 30 |
| abstract_inverted_index.(GP2–P4) | 113 |
| abstract_inverted_index.KLH–GP2. | 171 |
| abstract_inverted_index.abnormally | 54 |
| abstract_inverted_index.antibodies | 150 |
| abstract_inverted_index.comparison | 169 |
| abstract_inverted_index.conjugate. | 125 |
| abstract_inverted_index.conjugated | 116 |
| abstract_inverted_index.developing | 232 |
| abstract_inverted_index.inhibition | 179 |
| abstract_inverted_index.management | 244 |
| abstract_inverted_index.possessing | 96 |
| abstract_inverted_index.prevention | 28 |
| abstract_inverted_index.preventive | 237 |
| abstract_inverted_index.recognized | 16 |
| abstract_inverted_index.represents | 227 |
| abstract_inverted_index.strategies | 41 |
| abstract_inverted_index.efficacious | 212 |
| abstract_inverted_index.elucidating | 82 |
| abstract_inverted_index.lymphocytes | 100 |
| abstract_inverted_index.therapeutic | 194, 239 |
| abstract_inverted_index.vaccination | 40, 89 |
| abstract_inverted_index.demonstrated | 200 |
| abstract_inverted_index.encompassing | 220 |
| abstract_inverted_index.experiments. | 196 |
| abstract_inverted_index.neutralizing | 149 |
| abstract_inverted_index.polarization | 167 |
| abstract_inverted_index.prophylactic | 192 |
| abstract_inverted_index.Subsequently, | 172 |
| abstract_inverted_index.immunotherapy | 21 |
| abstract_inverted_index.multi-epitope | 217 |
| abstract_inverted_index.orchestrating | 210 |
| abstract_inverted_index.tumor-bearing | 188 |
| abstract_inverted_index.KLH–GP2–P4 | 124, 129, 144 |
| abstract_inverted_index.T-lymphocytes, | 222 |
| abstract_inverted_index.immunogenicity | 127 |
| abstract_inverted_index.overexpressing | 158 |
| abstract_inverted_index.antigen-specific | 148 |
| abstract_inverted_index.underappreciated | 70 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5064647317 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I885383172 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.699999988079071 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.7792663 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |