Hericerin derivatives activates a pan‐neurotrophic pathway in central hippocampal neurons converging to ERK1 /2 signaling enhancing spatial memory
Article Swipe
Ramón Martínez‐Mármol
,
YeJin Chai
,
Jacinta N. Conroy
,
Zahra Khan
,
Seong‐Min Hong
,
Seon Beom Kim
,
Rachel S. Gormal
,
Dae Hee Lee
,
Jae Kang Lee
,
Elizabeth J. Coulson
,
Mi Kyeong Lee
,
Sun Yeou Kim
,
Frédéric A. Meunier
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/jnc.15767
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/jnc.15767
The traditional medicinal mushroom Hericium erinaceus is known for enhancing peripheral nerve regeneration through targeting nerve growth factor (NGF) neurotrophic activity. Here, we purified and identified biologically new active compounds from H. erinaceus , based on their ability to promote neurite outgrowth in hippocampal neurons. N ‐de phenylethyl isohericerin (NDPIH), an isoindoline compound from this mushroom, together with its hydrophobic derivative hericene A, were highly potent in promoting extensive axon outgrowth and neurite branching in cultured hippocampal neurons even in the absence of serum, demonstrating potent neurotrophic activity. Pharmacological inhibition of tropomyosin receptor kinase B (TrkB) by ANA‐12 only partly prevented the NDPIH‐induced neurotrophic activity, suggesting a potential link with BDNF signaling. However, we found that NDPIH activated ERK1/2 signaling in the absence of TrkB in HEK‐293T cells, an effect that was not sensitive to ANA‐12 in the presence of TrkB. Our results demonstrate that NDPIH acts via a complementary neurotrophic pathway independent of TrkB with converging downstream ERK1/2 activation. Mice fed with H. erinaceus crude extract and hericene A also exhibited increased neurotrophin expression and downstream signaling, resulting in significantly enhanced hippocampal memory. Hericene A therefore acts through a novel pan‐neurotrophic signaling pathway , leading to improved cognitive performance. image
Related Topics
Concepts
Tropomyosin receptor kinase B
Hericium erinaceus
Neurotrophin
Neurite
Neurotrophic factors
Brain-derived neurotrophic factor
Nerve growth factor
Hippocampal formation
Chemistry
Cell biology
Signal transduction
Neuroscience
Biology
Receptor
Biochemistry
Raw material
Organic chemistry
In vitro
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/jnc.15767
- OA Status
- hybrid
- Cited By
- 29
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4317568202
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4317568202Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/jnc.15767Digital Object Identifier
- Title
-
Hericerin derivatives activates a pan‐neurotrophic pathway in central hippocampal neurons converging to
ERK1 /2 signaling enhancing spatial memoryWork title - Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-20Full publication date if available
- Authors
-
Ramón Martínez‐Mármol, YeJin Chai, Jacinta N. Conroy, Zahra Khan, Seong‐Min Hong, Seon Beom Kim, Rachel S. Gormal, Dae Hee Lee, Jae Kang Lee, Elizabeth J. Coulson, Mi Kyeong Lee, Sun Yeou Kim, Frédéric A. MeunierList of authors in order
- Landing page
-
https://doi.org/10.1111/jnc.15767Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1111/jnc.15767Direct OA link when available
- Concepts
-
Tropomyosin receptor kinase B, Hericium erinaceus, Neurotrophin, Neurite, Neurotrophic factors, Brain-derived neurotrophic factor, Nerve growth factor, Hippocampal formation, Chemistry, Cell biology, Signal transduction, Neuroscience, Biology, Receptor, Biochemistry, Raw material, Organic chemistry, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
29Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10, 2024: 5, 2023: 14Per-year citation counts (last 5 years)
- References (count)
-
64Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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