Herpes simplex virus 1 strain 17+ with R2 mutation in UL37 has residual retrograde transport Article Swipe
Marius Walter
,
Anoria K. Haick
,
Paola A Massa
,
Lindsay M. Klouser
,
Laurence Stensland
,
Tracy K. Santo
,
Hong Xie
,
Keith R. Jerome
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.06.25.661543
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.06.25.661543
Herpes simplex virus 1 (HSV-1) causes lifelong recurrent infections. Following primary infection of the oral or genital mucosa, HSV-1 travels retrogradely through axons and establishes latency in the cell body of ganglionic neurons of the peripheral nervous system. Periodic reactivation in neurons and anterograde transport of virions back to peripheral regions causes oral or genital ulcerations. Many host and viral factors implicated in retrograde and anterograde transport of HSV-1 have been identified. In particular, studies reported that introducing five amino acid substitutions in the R2 region of the viral tegument protein UL37 was sufficient to completely eliminate retrograde transport of HSV-1 strain F. Here, we introduced the same R2 mutations in the highly neurovirulent HSV-1 strain 17+. We report that this R2-17 virus has residual retrograde travel. We show that R2-17 can establish latency in mouse models of ocular and vaginal infection and reactivate. These results contradict published evidence and show that the R2 mutation is not sufficient to fully prevent retrograde transport of HSV-1.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.06.25.661543
- https://www.biorxiv.org/content/biorxiv/early/2025/06/26/2025.06.25.661543.full.pdf
- OA Status
- green
- References
- 15
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411699228
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411699228Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.06.25.661543Digital Object Identifier
- Title
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Herpes simplex virus 1 strain 17+ with R2 mutation in UL37 has residual retrograde transportWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-06-26Full publication date if available
- Authors
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Marius Walter, Anoria K. Haick, Paola A Massa, Lindsay M. Klouser, Laurence Stensland, Tracy K. Santo, Hong Xie, Keith R. JeromeList of authors in order
- Landing page
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https://doi.org/10.1101/2025.06.25.661543Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2025/06/26/2025.06.25.661543.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2025/06/26/2025.06.25.661543.full.pdfDirect OA link when available
- Concepts
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Herpes simplex virus, Virology, Strain (injury), Residual, Mutation, Virus strain, Axoplasmic transport, Simplex, Virus, Capsid, Biology, Anatomy, Genetics, Geometry, Mathematics, Gene, AlgorithmTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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15Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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