Heterogeneity of memory B cells Article Swipe
Anita S. Chong
,
Mohammed Javeed Ansari
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1111/ajt.14669
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1111/ajt.14669
Potential solid organ transplant recipients broadly sensitized to HLA have long wait times, low transplant rates and poor outcomes. The new kidney allocation system has improved access to the most highly sensitized recipients; however, their long-term outcomes are unknown. Emerging data suggest that memory B cell repertoire is broader than the plasma cell repertoire, therefore, despite refinements in anti-HLA antibody detection technology, donor-specific HLA- specific memory B cells may in fact be present in some, if not most, highly sensitized recipients with no detectable donor-specific antibodies. In addition, new findings have underscored the heterogeneity in memory B cell generation, and in the signals that determine memory versus plasma cell fate during primary antigen encounter, as well as memory B cell differentiation upon antigen reencounter into plasma cells or reentry into germinal centers to subsequently emerge as higher affinity and class-switched plasma cells. Thus, heterogeneity memory B cells generation may affect the efficacy of specific immunomodulation during the recall response. We propose that the ability to quantify donor-specific B cell in transplant recipients is urgently required to provide insights into the mechanisms of sensitization and recall, and for the early detection of acute and chronic AMR.
Related Topics
Concepts
Memory B cell
Germinal center
Immunology
Human leukocyte antigen
Medicine
Repertoire
Antibody
B cell
Antigen
Plasma cell
Recall
Naive B cell
Immune system
Antigen-presenting cell
T cell
Psychology
Acoustics
Cognitive psychology
Physics
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1111/ajt.14669
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ajt.14669
- OA Status
- hybrid
- Cited By
- 25
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2792122034
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2792122034Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/ajt.14669Digital Object Identifier
- Title
-
Heterogeneity of memory B cellsWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-01-23Full publication date if available
- Authors
-
Anita S. Chong, Mohammed Javeed AnsariList of authors in order
- Landing page
-
https://doi.org/10.1111/ajt.14669Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ajt.14669Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ajt.14669Direct OA link when available
- Concepts
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Memory B cell, Germinal center, Immunology, Human leukocyte antigen, Medicine, Repertoire, Antibody, B cell, Antigen, Plasma cell, Recall, Naive B cell, Immune system, Antigen-presenting cell, T cell, Psychology, Acoustics, Cognitive psychology, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
25Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 3, 2023: 8, 2022: 1, 2020: 6Per-year citation counts (last 5 years)
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66Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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