Heterogeneity of small duct‐ and large duct‐type intrahepatic cholangiocarcinoma Article Swipe
Maximilian N. Kinzler
,
Falko Schulze
,
Jan Jeroch
,
Christina Schmitt
,
Silvana Ebner
,
Steffen Gretser
,
Julia Bein
,
Fabian Finkelmeier
,
Jörg Trojan
,
Stefan Zeuzem
,
Andreas A. Schnitzbauer
,
Melanie Demes
,
Henning Reis
,
Peter J. Wild
,
Dirk Walter
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/his.15162
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/his.15162
Aims The histological subtype of intrahepatic cholangiocarcinoma (iCCA) is associated with different mutational characteristics that impact clinical management. So far, data are lacking on the presence of small duct iCCA (SD‐iCCA) and large duct iCCA (LD‐iCCA) in a single patient. The aim of the current study was to determine the presence and degree of intratumoural heterogeneity of SD‐ and LD‐iCCA features in different tumour regions. Methods and results All patients treated with surgically resected iCCA at Frankfurt University Hospital between December 2005 and March 2023 were retrospectively analysed. Histomorphological features of SD‐ and LD‐iCCA were evaluated by an expert hepatobiliary pathologist. Tissue samples suspicious for subtype heterogeneity were further investigated. Immunohistochemistry for N‐cadherin, S100P, MUC5AC, MUC6, TFF1 and AGR2 and mutational profiling with the Illumina TruSight Oncology 500 (TSO500) assay were performed separately for the SD‐ and LD‐iCCA regions. Of 129 patients with surgically resected iCCA, features of either SD‐ or LD‐iCCA were present in 67.4% ( n = 87) and 24.8% of the patients ( n = 32), respectively; 7.8% ( n = 10) had histomorphological features of both SD‐ and LD‐iCCA, seven patients (5.4%) of which had sufficient formalin‐fixed, paraffin‐embedded tissue for further analysis. Heterogeneity of both subtypes could be confirmed with immunohistochemistry. In five of seven (71.4%) patients, molecular profiling revealed intratumoural differences in genetic alterations between the SD‐ and LD‐iCCA region. In one patient, a BRAF mutation (p.V600E) was found in the SD‐iCCA but not in the LD‐iCCA region of the tumour. Conclusions A marked portion of patients with iCCA exhibits both SD‐ and LD‐iCCA in different tumour regions. In case of the presence of histopathological heterogeneity, mutational profiling should be considered to avoid missing therapeutically relevant genetic alterations.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/his.15162
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/his.15162
- OA Status
- hybrid
- Cited By
- 6
- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W4392194699
All OpenAlex metadata
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https://openalex.org/W4392194699Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/his.15162Digital Object Identifier
- Title
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Heterogeneity of small duct‐ and large duct‐type intrahepatic cholangiocarcinomaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-02-26Full publication date if available
- Authors
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Maximilian N. Kinzler, Falko Schulze, Jan Jeroch, Christina Schmitt, Silvana Ebner, Steffen Gretser, Julia Bein, Fabian Finkelmeier, Jörg Trojan, Stefan Zeuzem, Andreas A. Schnitzbauer, Melanie Demes, Henning Reis, Peter J. Wild, Dirk WalterList of authors in order
- Landing page
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https://doi.org/10.1111/his.15162Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/his.15162Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/his.15162Direct OA link when available
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Intrahepatic Cholangiocarcinoma, Immunohistochemistry, Bile duct, Medicine, Pathology, Internal medicine, GastroenterologyTop concepts (fields/topics) attached by OpenAlex
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6Total citation count in OpenAlex
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2025: 5, 2024: 1Per-year citation counts (last 5 years)
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18Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Tissue | 101 |
| abstract_inverted_index.degree | 52 |
| abstract_inverted_index.either | 148 |
| abstract_inverted_index.expert | 98 |
| abstract_inverted_index.impact | 15 |
| abstract_inverted_index.marked | 248 |
| abstract_inverted_index.region | 242 |
| abstract_inverted_index.should | 273 |
| abstract_inverted_index.single | 38 |
| abstract_inverted_index.tissue | 192 |
| abstract_inverted_index.tumour | 63, 261 |
| abstract_inverted_index.(71.4%) | 209 |
| abstract_inverted_index.MUC5AC, | 114 |
| abstract_inverted_index.Methods | 65 |
| abstract_inverted_index.between | 79, 219 |
| abstract_inverted_index.current | 44 |
| abstract_inverted_index.further | 108, 194 |
| abstract_inverted_index.genetic | 217, 281 |
| abstract_inverted_index.lacking | 22 |
| abstract_inverted_index.missing | 278 |
| abstract_inverted_index.portion | 249 |
| abstract_inverted_index.present | 153 |
| abstract_inverted_index.region. | 224 |
| abstract_inverted_index.results | 67 |
| abstract_inverted_index.samples | 102 |
| abstract_inverted_index.subtype | 3, 105 |
| abstract_inverted_index.treated | 70 |
| abstract_inverted_index.tumour. | 245 |
| abstract_inverted_index.(TSO500) | 128 |
| abstract_inverted_index.December | 80 |
| abstract_inverted_index.Hospital | 78 |
| abstract_inverted_index.Illumina | 124 |
| abstract_inverted_index.Oncology | 126 |
| abstract_inverted_index.TruSight | 125 |
| abstract_inverted_index.clinical | 16 |
| abstract_inverted_index.exhibits | 254 |
| abstract_inverted_index.features | 60, 89, 146, 177 |
| abstract_inverted_index.mutation | 230 |
| abstract_inverted_index.patient, | 227 |
| abstract_inverted_index.patient. | 39 |
| abstract_inverted_index.patients | 69, 141, 164, 184, 251 |
| abstract_inverted_index.presence | 25, 50, 267 |
| abstract_inverted_index.regions. | 64, 138, 262 |
| abstract_inverted_index.relevant | 280 |
| abstract_inverted_index.resected | 73, 144 |
| abstract_inverted_index.revealed | 213 |
| abstract_inverted_index.subtypes | 199 |
| abstract_inverted_index.(p.V600E) | 231 |
| abstract_inverted_index.Frankfurt | 76 |
| abstract_inverted_index.LD‐iCCA | 59, 93, 137, 151, 223, 241, 258 |
| abstract_inverted_index.SD‐iCCA | 236 |
| abstract_inverted_index.analysed. | 87 |
| abstract_inverted_index.analysis. | 195 |
| abstract_inverted_index.confirmed | 202 |
| abstract_inverted_index.determine | 48 |
| abstract_inverted_index.different | 11, 62, 260 |
| abstract_inverted_index.evaluated | 95 |
| abstract_inverted_index.molecular | 211 |
| abstract_inverted_index.patients, | 210 |
| abstract_inverted_index.performed | 131 |
| abstract_inverted_index.profiling | 121, 212, 272 |
| abstract_inverted_index.LD‐iCCA, | 182 |
| abstract_inverted_index.University | 77 |
| abstract_inverted_index.associated | 9 |
| abstract_inverted_index.considered | 275 |
| abstract_inverted_index.mutational | 12, 120, 271 |
| abstract_inverted_index.separately | 132 |
| abstract_inverted_index.sufficient | 189 |
| abstract_inverted_index.surgically | 72, 143 |
| abstract_inverted_index.suspicious | 103 |
| abstract_inverted_index.(LD‐iCCA) | 35 |
| abstract_inverted_index.(SD‐iCCA) | 30 |
| abstract_inverted_index.Conclusions | 246 |
| abstract_inverted_index.alterations | 218 |
| abstract_inverted_index.differences | 215 |
| abstract_inverted_index.management. | 17 |
| abstract_inverted_index.alterations. | 282 |
| abstract_inverted_index.histological | 2 |
| abstract_inverted_index.intrahepatic | 5 |
| abstract_inverted_index.pathologist. | 100 |
| abstract_inverted_index.Heterogeneity | 196 |
| abstract_inverted_index.N‐cadherin, | 112 |
| abstract_inverted_index.hepatobiliary | 99 |
| abstract_inverted_index.heterogeneity | 55, 106 |
| abstract_inverted_index.intratumoural | 54, 214 |
| abstract_inverted_index.investigated. | 109 |
| abstract_inverted_index.respectively; | 169 |
| abstract_inverted_index.heterogeneity, | 270 |
| abstract_inverted_index.characteristics | 13 |
| abstract_inverted_index.retrospectively | 86 |
| abstract_inverted_index.therapeutically | 279 |
| abstract_inverted_index.formalin‐fixed, | 190 |
| abstract_inverted_index.histopathological | 269 |
| abstract_inverted_index.Histomorphological | 88 |
| abstract_inverted_index.cholangiocarcinoma | 6 |
| abstract_inverted_index.histomorphological | 176 |
| abstract_inverted_index.paraffin‐embedded | 191 |
| abstract_inverted_index.Immunohistochemistry | 110 |
| abstract_inverted_index.immunohistochemistry. | 204 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5081995074 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| corresponding_institution_ids | https://openalex.org/I114090438, https://openalex.org/I4210132578 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5699999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.94365088 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |